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Nanoparticles May Help Surgeons by Tagging Brain Tumors

By MedImaging International staff writers
Posted on 01 Jun 2010

Researchers have developed a way to enhance how brain tumors appear on magnetic resonance imaging (MRI) scans and during surgery, making the tumors easier for surgeons to identify and remove.

Scientists from Ohio State University (Columbus, USA) are experimenting with different nanoparticles that they hope may one day be injected into the blood of patients and help surgeons remove lethal brain tumors known as glioblastomas.

In the April 9, 2010, issue of the journal Nanotechnology, researchers reported that they have manufactured a small particle called a nanocomposite that is both magnetic and fluorescent. These nanocomposites measure less than 20 nm in size. "Our strategy is combining two particles that contain different properties to make one particle with multiple properties,” explained Dr. Jessica Winter, assistant professor in chemical and biomolecular engineering and biomedical engineering at Ohio State.

The magnetic nanoparticles highlight color contrasts within MRI scans, allowing clinicians to see potential or existing cancerous tumors before surgery. The fluorescent nanoparticles can change the color that the tumor appears in the brain when seen under a special light.

Neurologic surgeons could benefit from a multifunctional particle that would allow them to better see the tumor with an MRI before surgery, and then see it physically during surgery, according to Dr. Winter. "We're trying to develop a single nanocomposite that's magnetic--so you can do preoperative MRI--and that's fluorescent--so that when neurological surgeons go into surgery, they can shine a light on the tumor and it will glow a specific color such as green, for example. Then, the surgeon can simply remove all of the green,” Dr. Winter stated.

Dr. Winter's study provided convincing proof that a particle with dual properties can be formed. However, these multifunctional particles cannot be used for animal or human testing because the fluorescent particle, cadmium telluride, is toxic. "We're currently working on an alternative fluorescent particle which is composed of carbon. This will eliminate the complications that arise with ingesting the cadmium telluride particles,” Dr. Winter said.

One of the successes in creating the new nanocomposite particle was how they did it, Dr. Winter noted. It is typically difficult to combine particles such as these, a process known as doping. The Ohio State researchers pursued an approach, which had not been tried before. They chose to bind their fluorescent particle on top of their magnetic particle at extremely high temperatures.

"The key is that our synthesis is done at pretty high temperatures--about 350 ^oC Dr. Winter explained. "The synthesis was unexpected, but cool at the same time, and we were excited when we saw what we got.”

The lead neurologic surgeon that collaborates with Dr. Winter and her team, an assistant professor with the department of neurological surgery, Dr. Atom Sarkar, hopes to assess the application on animals at some point. First, they have to produce a particle that contains no toxic ingredients. If results continue to be encouraging, Dr. Winter is optimistic that similar multifunctional particles could become an innovative part of neurologic surgery within the next five years.

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60 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

61 (!!!!! 1196.8612670898): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 1163.0058288574): SELECT fid FROM jos_deeppockets WHERE id=294729561 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294729561 AND published='1' LIMIT 1

63 (720.02410888672): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (!!!!! 3062.0098114014): select jos_twitters.link from jos_twitters where cat=10

65 (65.088272094727): select jos_facebook.link from jos_facebook where cat=10

66 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

67 (54.121017456055): select jos_linkedin.link from jos_linkedin where cat=10

68 (82.015991210938): SELECT fid FROM jos_deeppockets WHERE id=294729561 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294729561 AND published='1' LIMIT 1

69 (45.7763671875): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (838.9949798584): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729561 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (355.00526428223): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729561 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (55.074691772461): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (505.20896911621): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (161.88621520996): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (!!!!! 1540.8992767334): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (181.91337585449): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (298.02322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (97.036361694336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (171.18453979492): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (430.10711669922): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729561 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (283.95652770996): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729561 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (48.160552978516): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (419.85511779785): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (47.206878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (135.89859008789): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (!!!!! 3635.1680755615): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (164.98565673828): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

105 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

106 (123.02398681641): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729561 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (80.108642578125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729561 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

109 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

110 (80.108642578125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294729561 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (620.12672424316): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294729561 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (611.0668182373): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (798.94065856934): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (268.93615722656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

115 (255.10787963867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

116 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

117 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

118 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

119 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

120 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

121 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

122 (426.05400085449): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 47017.097473145): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 4069.0898895264): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729561 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729561 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 9441.8525695801): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (63.896179199219): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (343.79959106445): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (231.02760314941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (206.94732666016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (118.01719665527): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (202.89421081543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (510.93101501465): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (412.94097900391): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (258.9225769043): SELECT name FROM jos_deeppockets WHERE id=212

138 (41.961669921875): SELECT name FROM jos_deeppockets WHERE id=212

139 (731.9450378418): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (643.01490783691): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

142 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

143 (!!!!! 9184.8373413086): TRUNCATE TABLE jos_trademed_module

144 (106.0962677002): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729561 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729561 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (774.86038208008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

149 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

150 (!!!!! 1432.8956604004): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (55.789947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

152 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

153 (50.067901611328): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729561 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729561 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (34.093856811523): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

158 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729561 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729561 AND published='1' LIMIT 1

159 (89.883804321289): select jos_twitters.link from jos_twitters where cat=10

160 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

161 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

162 (26.226043701172): select jos_linkedin.link from jos_linkedin where cat=10

163 (250.10108947754): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (900.0301361084): insert into jos_banners_delta values (14615,'2025-06-28 07:02:16','216.73.216.249','view'),(14202,'2025-06-28 07:02:16','216.73.216.249','view'),(14203,'2025-06-28 07:02:16','216.73.216.249','view')

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