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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Rapid MRI Analysis Method Developed to Diagnose Alzheimer's Disease

By MedImaging International staff writers
Posted on 29 Mar 2010

Image: Colored magnetic resonance imaging (MRI) scan of a section through the brain of a 68-year-old patient suffering from Alzheimer’s disease (photo courtesy of Zephyr).

Finnish scientists have developed a method for analyzing magnetic resonance (MR) images in only a few minutes when diagnosing Alzheimer's disease (AD). The accuracy of the analysis is comparable to manual measurements made by skilled professionals, which are currently considered the most effective application for diagnosing AD. The accurate and rapid analysis method is well suited for clinical use.

Early detection of Alzheimer's disease requires that the patient displays some other symptom or sign of AD in addition to memory problems. Such other symptoms include atrophy, i.e., the loss of brain cells, visible in MR images. One of the first areas of the brain where atrophy can be detected is the hippocampus. With this new method, developed by researchers from the VTT Technical Research Center (Espoo, Finland), the volume of the hippocampus can be accurately calculated automatically.

Currently, diagnosis of AD often makes use of visual assessment of MR images. Manual determination of brain structures in this way is a difficult task for the physician, and the repeatability of results typically poor. This has led to a high demand for objective methods. Earlier automatic systems for calculating the volume of the hippocampus are not in general clinical use because of deficiencies in speed and effectiveness.

Using VTT's new approach, the evaluation of MR images takes three minutes. With the fastest currently available automatic MR image assessment methods, the assessment takes 15 to 20 minutes. However, it is not uncommon for assessments to last for several hours.

The new method is part of a system, which is currently being developed under the European Union (EU) PredictAD project (Tampere, Finland) to help diagnose AD. The system will be completed in 2011. The goal of the project is to develop objective methods that are sufficiently accurate, effective, and fast for clinical use but do not require large investments in equipment.

Other organizations involved in developing the new method include GE Healthcare (Chalfont St. Giles), Imperial College London (UK), University of Eastern Finland (Kuopio, Finland) and Rigshospitalet (Copenhagen, Denmark). The method is currently being tested to confirm its operational effectiveness.

Related Links:
VTT Technical Research Center
EU PredictAD project

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65 (33.140182495117): select jos_facebook.link from jos_facebook where cat=10

66 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

67 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

68 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294728706 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294728706 AND published='1' LIMIT 1

69 (30.994415283203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (281.09550476074): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294728706 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (216.00723266602): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294728706 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (37.908554077148): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (44.822692871094): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294728706 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294728706 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (34.093856811523): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (132.08389282227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

105 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

106 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294728706 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (64.13459777832): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294728706 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

109 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

110 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294728706 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (653.02848815918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294728706 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (511.16943359375): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (326.87187194824): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

115 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

116 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

117 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

118 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

119 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

120 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

121 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

122 (266.07513427734): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 24398.0884552): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (677.10876464844): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294728706 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294728706 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 10953.903198242): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (107.0499420166): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (69.856643676758): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (74.863433837891): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (405.07316589355): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (92.029571533203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (322.10350036621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (236.98806762695): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (112.05673217773): SELECT name FROM jos_deeppockets WHERE id=212

138 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=212

139 (508.06999206543): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (686.1686706543): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (154.97207641602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

142 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

143 (!!!!! 11257.886886597): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1117.9447174072): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294728706 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (554.08477783203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294728706 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (869.9893951416): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (416.99409484863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

149 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

150 (!!!!! 1284.122467041): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

152 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

153 (36.001205444336): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294728706 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294728706 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (29.087066650391): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (50.067901611328): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

158 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294728706 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294728706 AND published='1' LIMIT 1

159 (567.91305541992): select jos_twitters.link from jos_twitters where cat=10

160 (36.954879760742): select jos_facebook.link from jos_facebook where cat=10

161 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

162 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

163 (316.85829162598): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1082.181930542): insert into jos_banners_delta values (14615,'2025-06-28 14:13:44','216.73.216.249','view'),(14202,'2025-06-28 14:13:44','216.73.216.249','view'),(14203,'2025-06-28 14:13:44','216.73.216.249','view')

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