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Particle Characterization System Critical to Development of Brain Tumor Illumination

By MedImaging International staff writers
Posted on 05 Feb 2010
A particle characterization system is proving to be a creative research tool for advanced healthcare applications such as gene therapy and selective-target carrier molecules.

The University of Washington (Seattle, WA, USA) researchers reported that accurate zeta potential and particle size measurements were critical to their successful development of fluorescent, tumor-targeting iron oxide nanoparticles. Able to safely cross the blood-brain barrier and selectively illuminate brain cancer cells during a magnetic resonance imaging (MRI) scan, the innovative molecules resulting from this research should make brain cancer imaging much safer.

"Safe molecular penetration of the blood-brain barrier depends on a particle's size, fat content, and electric charge. It wasn't until we obtained the Zetasizer Nano in 2006 that we were able to efficiently measure, monitor, and optimize these properties and develop nanoparticles that deliver the desired half-life in blood but remain stable long enough to support imaging,” explained Prof. Miqin Zhang, from the University of Washington's department of materials science and engineering. The Zetasizer Nano system was developed by Malvern Instruments (Malvern, UK).

The blood-brain barrier protects the brain from infection. Current imaging techniques require the injection of both dyes and a drug to forcefully open the barrier. Prof. Zhang and her team have formulated particles approximately 33 nm in diameter. Three times smaller in wet conditions than anything previously formulated in the lab, these particles can naturally penetrate the blood-brain barrier without exposing the patient to the risk of infection, and represent a highly significant advance in brain cancer imaging.

The Nanoparticle Lab within the University of Washington's department of materials science and engineering focuses its research on cancer diagnosis and treatment through imaging enhancement and targeted and controlled therapeutic payload delivery. This is accomplished by use of nanoconjugates or multifunctional nanovectors. A nanoconjugate is a chemically modified nanoparticle serving as a "vehicle” that carries biomolecules to target cells. The term "nanovector” here refers to a nanosized entity that plays a functional role in the perspective of therapeutics.

Malvern Instruments provides a range of complementary materials characterization tools that deliver interrelated measurements reflecting the complexities of particulates and disperse systems, nanomaterials and macromolecules. Analytic instruments from Malvern are used in the characterization of a wide variety of materials, from industrial bulk powders to nanomaterials and delicate macromolecules. A wide range of innovative technologies is combined with intelligent, user-friendly software. These systems provide industrially relevant data enabling the customers to make the connection between micro (such as particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging).

Particle size, particle shape, zeta potential, molecular weight, chemical composition and rheologic properties measurements are combined by advanced chromatography systems (GPC/SEC), extending Malvern's technologies for protein molecular weight, size, and aggregation measurements, and synthetic polymer molecular weight and distribution.

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University of Washington
Malvern Instruments


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92 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
105 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
106 (50.783157348633): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727822 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727822 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
109 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
110 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294727822 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (501.15585327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294727822 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (628.94821166992): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (387.90702819824): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
115 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
116 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
117 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
118 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
119 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
120 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
121 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
122 (329.97131347656): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 23128.032684326): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (719.07043457031): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727822 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727822 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 8494.1387176514): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (70.810317993164): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (29.802322387695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (95.129013061523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (283.95652770996): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (467.06199645996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (370.02563476562): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (51.975250244141): SELECT name FROM jos_deeppockets WHERE id=212
138 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=212
139 (540.97175598145): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (593.90068054199): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
142 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
143 (!!!!! 8939.9814605713): TRUNCATE TABLE jos_trademed_module
144 (115.15617370605): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727822 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727822 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (941.99180603027): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
149 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
150 (!!!!! 1149.8928070068): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
152 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
153 (58.889389038086): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727822 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727822 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (49.829483032227): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
155 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
156 (51.975250244141): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
158 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727822 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727822 AND published='1' LIMIT 1
159 (57.93571472168): select jos_twitters.link from jos_twitters where cat=10
160 (40.054321289062): select jos_facebook.link from jos_facebook where cat=10
161 (39.100646972656): select jos_google_plus.link from jos_google_plus where cat=10
162 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10
163 (376.93977355957): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
164 (!!!!! 1122.9515075684): insert into jos_banners_delta values (14615,'2025-06-28 11:32:41','216.73.216.249','view'),(14202,'2025-06-28 11:32:41','216.73.216.249','view'),(14203,'2025-06-28 11:32:41','216.73.216.249','view')