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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Researchers Help Revolutionize Medical Care Worldwide with MR-Guided Focused Ultrasound Technology

By MedImaging International staff writers
Posted on 26 Oct 2009

Magnetic resonance-guided focused ultrasound (MRgFUS) is fast becoming a technology that has the potential to transform medical care worldwide.

"We're at the same point with focused ultrasound as we were with diagnostic MRIs several decades ago,” stated Neal F. Kassell, M.D., a professor of neurosurgery at the University of Virginia's School of Medicine (UVA; Charlottesville, USA) and an internationally known proponent of focused ultrasound research and development. "Back in the 80s, no one knew about MRI. Today, just about everyone has either had one or knows someone who has had an MRI. That's how commonplace it is.”

Dr. Kassell believes that MRgFUS--the technologic merging of MRI and focused ultrasound--may be the most important therapeutic development since the scalpel. That notion will soon be explored by dozens of his colleagues from nine specialties who engaged in a program of research projects and clinical trials at UVA's new Focused Ultrasound Center, which was dedicated on September 14, 2009.

Specialists performing research at the UVA center will represent a wide range of disciplines, including anesthesiology, biomedical engineering, gynecology, neurology, neurosurgery, oncology, radiology, radiation oncology surgery, and urology. Shortly, their research will focus on using MRgFUS to treat brain, breast, prostate, bone, and liver tumors and conditions such as epilepsy, stroke, chronic pain, Parkinson's disease, and essential tremor.

During MRgFUS treatments, which are noninvasive and performed on an outpatient basis, patients lie on a table while doctors use the visual capabilities of MRI to direct hundreds of individual and normally harmless sound waves at a single treatment point deep inside the body. "When they intersect, ultrasound waves have enough energy to destroy tumor cells, much like sun beams can be focused with a magnifying glass to burn a hole through a piece of paper,” explained Alan H. Matsumoto, M.D. "The technology is so precise that it can treat sites as small as a millimeter, which is about half the size of a grain of rice.”

In addition to conducting research, Dr. Matsumoto, who is chairman of UVA's department of radiology and codirector of the new center, will provide focused ultrasound treatments to patients with uterine fibroids. "This is the first focused ultrasound treatment approved by the FDA [U.S. Food and Drug Administration], and it will be an important addition to the range of therapies we offer to patients with uterine fibroids,” he commented.

Treatments, which will become available in late October 2009, will take about three hours. Side effects, if any, are typically minimal (slight cramping is most common) and patients can expect to feel well enough to resume daily activities almost immediately.

Looking ahead, James M. Larner, M.D., director of UVA's Focused Ultrasound Center and chairman of the department of radiation oncology, reported that a case-by-case approach will be taken to prove the safety and efficacy of the new technology for treating other conditions. "I'm cautious by nature,” he said, "but have to admit I'm really excited about the possibilities of focused ultrasound and the benefits it may offer our patients.”

As a radiation oncologist, Dr. Larner is impressed by focused ultrasound's ability to destroy 100% of cancer cells. "Chemotherapy kills a certain percentage of malignant cells, but not all of them,” he noted. Three other aspects of MRgFUS intrigue Dr. Larner. First, its imaging capabilities let clinicians watch as ultrasound heat destroys cells. "This can give us a new level of certainty about how well our treatments work,” he remarked. Second, cancer cells cannot become resistant to focused ultrasound. By contrast, cell resistance ultimately limits the effectiveness of all chemotherapies. Finally, focused ultrasound has a rapid dosing drop off, meaning the technology concentrates high levels of heat on a target site but does not spill over to nearby healthy tissue, potentially causing damage or patient complications.

UVA's new center, which is one of 90 focused ultrasound sites worldwide, is the first to use its MRgFUS equipment solely to perform research and treatments. "Every day that this technology is not widely available means people are suffering and dying needlessly,” Dr. Kassell said. "That's what makes it such an urgent matter. We are fortunate to have some of today's smartest and most talented people participating in our multi-disciplinary research program. They have what it takes to lead the way in this emerging field of medicine.”

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56 (400.06637573242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294726125 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1085.9966278076): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

58 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

59 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

60 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

61 (69.856643676758): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (494.95697021484): SELECT fid FROM jos_deeppockets WHERE id=294726125 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294726125 AND published='1' LIMIT 1

63 (350.9521484375): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

65 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

66 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

68 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294726125 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294726125 AND published='1' LIMIT 1

69 (36.001205444336): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (242.23327636719): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294726125 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (230.07392883301): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294726125 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294726125 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (32.901763916016): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294726125 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.226043701172): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

105 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

106 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294726125 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294726125 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

109 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

110 (80.108642578125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294726125 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (468.01567077637): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294726125 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (517.12989807129): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (404.83474731445): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

115 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

116 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

117 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

118 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

119 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

120 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

121 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

122 (300.88424682617): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 19038.200378418): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (483.03604125977): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294726125 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294726125 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7266.9982910156): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (84.161758422852): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (302.07633972168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (224.11346435547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (180.95970153809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (213.1462097168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (467.77725219727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (364.06517028809): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (294.92378234863): SELECT name FROM jos_deeppockets WHERE id=212

138 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=212

139 (591.99333190918): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (486.13548278809): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

142 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

143 (!!!!! 8137.9413604736): TRUNCATE TABLE jos_trademed_module

144 (102.99682617188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294726125 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294726125 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (853.06167602539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

149 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

150 (!!!!! 1133.918762207): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

152 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

153 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294726125 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294726125 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (34.093856811523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (40.054321289062): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (161.88621520996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

158 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294726125 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294726125 AND published='1' LIMIT 1

159 (110.14938354492): select jos_twitters.link from jos_twitters where cat=10

160 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

161 (32.901763916016): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

163 (705.00373840332): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1209.020614624): insert into jos_banners_delta values (14615,'2025-06-29 03:26:18','216.73.216.249','view'),(14202,'2025-06-29 03:26:18','216.73.216.249','view'),(14203,'2025-06-29 03:26:18','216.73.216.249','view')

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