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fMRI Reveals Brain Defect Implicated in Early Schizophrenia

By MedImaging International staff writers
Posted on 17 Sep 2009

In the first functional magnetic resonance imaging (fMRI) study of its type, neurologists and psychiatrists have identified a region of the brain involved in the earliest stages of schizophrenia and related psychotic disorders. Activity in this specific region of the hippocampus may help predict the onset of the disease, providing opportunities for earlier diagnosis and for the development of drugs for schizophrenia prevention.

The research findings were published in the September 7, 2009, issue of the journal Archives of General Psychiatry. In the study, the researchers scanned the brains of 18 high-risk individuals with "prodromal” symptoms, and followed them for two years. Of those individuals who went on to develop first-episode psychotic disorders such as schizophrenia, 70% had abnormally high activity in this region of the hippocampus, known as the CA1 subfield.

Whereas previous research have identified a more general increase in activity in the hippocampus in chronic schizophrenia, this study demonstrated that in the early stages of the illness, before symptoms are fully manifest, this increased activity is evident only in this one subregion and can differentiate who among high-risk individuals will go on to develop these disorders.

fMRI is a noninvasive technique that measures brain metabolism, indicating what parts of the brain are active during which activities. Mapping cerebral blood volume (CBV) is a method used in fMRI to measure this activity and it indicates increases or decreases in metabolism. Using an innovative high-resolution application of fMRI, pioneered by lead study investigator Scott A. Small, M.D., the researchers first compared 18 patients with schizophrenia to 18 healthy controls and observed abnormalities in multiple areas of the brains of the patients with schizophrenia. Next, to learn which of those regions of the brain were targeted first in patients with first-episode psychotic disorders, such as schizophrenia, the investigators imaged young individuals identified as at high risk for psychosis, who were then followed for two years to determine diagnostic outcome.

"By applying this imaging technology to a population of high-risk individuals, we wanted to see if we could find an area of the brain that is selectively targeted,” said first author Scott A. Schobel, M.D., assistant professor of clinical psychiatry at Columbia and the New York State Psychiatric Institute. "In comparing those high-risk individuals who developed psychosis with those who did not, we found that only the CA1 subfield was abnormal in those young people who went on to develop schizophrenia. We believe that this may give us an early snapshot of disease.”

"What many brain disorders have in common is that they are all relatively invisible to conventional imaging techniques,” said Dr. Small, associate professor of neurology in the Sergievsky Center and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain at Columbia University Medical Center (New York, NY, USA). "It is crucial to be able to visualize the most affected area of the brain and to pinpoint the region that is most vulnerable. This will give us clues into the causes of the disease. Our findings could help us improve diagnosis in the preclinical stage, which is most important because it is this stage of the disease that will be most amenable to treatment.”

Currently, no tests are available to diagnose schizophrenia. Diagnosis is mostly based on clinical symptoms after tests to rule out other possible causes. "Right now, the odds of knowing who will go on to develop schizophrenia from the prodromal stage is only a little better than a coin toss,” said Dr. Schobel.

To meet the criteria for a prodromal group, subjects need to present with what clinicians call "subthreshold” psychotic symptoms. "These involve illusions [hearing one's name in the wind] rather than hallucinations [hearing voices] or overvalued unusual ideas that lack the conviction of clear delusions, such as feeling suspicious of others but without a sense of being singled out or persecuted,” said Cheryl Corcoran, M.D., assistant professor of clinical Psychiatry and director of the Center for Prevention and Evaluation, a prodromal research program at Columbia and the New York State Psychiatric Institute (New York, NY, USA). "Persons who have a family member with a known psychotic disorder, and also experience some kind of social withdrawal, would also meet the criteria, as would an individual who shows up at the emergency room with a temporary full-blown psychosis.”

Of a typical prodromal cohort, approximately 35% will go on to develop a full-blown psychotic disorder, usually schizophrenia, at 2.5 years. "We're hoping that applying this imaging technique can enhance our knowledge of who might go on to develop schizophrenia and related disorders, since early diagnosis and early intervention are so important,” said Dr. Schobel.

"We're now trying to understand why CA1 is selectively targeted. We need to ask what is the underlying cause and to find a pattern and investigate why this area is affected first. It may be that the CA1 subfield is also driving dysfunction in other brain regions in establishing the illness,” said Dr. Small.

In spite of the strength of the findings in this small population of patients, imaging of a larger group and replication of the findings are needed to clarify how effective and specific this is for diagnosing preclinical schizophrenia. "A larger study will determine if this is really a true biomarker that can be used as a diagnostic tool for identifying risk for schizophrenia on an individual basis,” said Dr. Small.

Contrary to popular belief, schizophrenia is not a split personality; it is a chronic, severe, and disabling brain disorder that affects just over 1% of the adult population and is characterized by loss of contact with reality (psychosis), hallucinations (usually, hearing voices), strongly held false beliefs (delusions), abnormal thinking, a restricted range of emotions (flattened affect), or inappropriate and disorganized behavior, social withdrawal, and diminished motivation.

"Research has shown that early intervention and treatment can prevent the debilitating effects of schizophrenia by dramatically slowing progression, reducing mortality and disability, and increasing recovery of one of mankind's most costly mental disorders,” said Jeffrey A. Lieberman, M.D., an expert in the field of schizophrenia, who has recently been selected by the National Institute of Mental Health (NIMH) of the National Institutes of Health (Bethesda, MD, USA), and professor and chairman, department of psychiatry, Columbia University College of Physicians and Surgeons, to lead a U.S. effort to develop an optimal early intervention strategy for treating people experiencing a first-episode of the psychotic symptoms of schizophrenia.

Related Links:
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48 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

49 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

50 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

51 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

52 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

53 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

54 (460.86311340332): SELECT name FROM jos_deeppockets WHERE id=294725449 LIMIT 1

55 (432.96813964844): SELECT name FROM jos_deeppockets_archive WHERE id=294725449 LIMIT 1

56 (72.956085205078): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

57 (102.99682617188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725449 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (688.07601928711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725449 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1152.0385742188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

60 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

61 (!!!!! 4222.8698730469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

62 (121.11663818359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

63 (!!!!! 3321.8860626221): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (524.99771118164): SELECT fid FROM jos_deeppockets WHERE id=294725449 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294725449 AND published='1' LIMIT 1

65 (46.014785766602): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

66 (44.107437133789): select jos_twitters.link from jos_twitters where cat=10

67 (28.848648071289): select jos_facebook.link from jos_facebook where cat=10

68 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

69 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

70 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294725449 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294725449 AND published='1' LIMIT 1

71 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

72 (283.95652770996): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725449 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (211.00044250488): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725449 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (41.007995605469): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725449 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725449 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (35.04753112793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (64.13459777832): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 1206.1595916748): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

107 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

108 (92.983245849609): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725449 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (538.82598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725449 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (121.8318939209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

111 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

112 (456.09474182129): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725449 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (445.84274291992): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725449 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (70.810317993164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725448 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (414.13307189941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725448 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (634.90867614746): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (504.97055053711): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

119 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

120 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

121 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

122 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

123 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

124 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

125 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

126 (288.00964355469): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 49681.901931763): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (715.97099304199): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725449 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725449 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 24626.970291138): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (109.91096496582): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (69.856643676758): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (68.902969360352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (457.0484161377): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (62.942504882812): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (57.93571472168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (!!!!! 1173.9730834961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (554.08477783203): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (56.982040405273): SELECT name FROM jos_deeppockets WHERE id=212

142 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=212

143 (763.89312744141): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (!!!!! 2401.1135101318): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

146 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

147 (!!!!! 16645.193099976): TRUNCATE TABLE jos_trademed_module

148 (!!!!! 2834.0816497803): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725449 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (88.930130004883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725449 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (!!!!! 1437.9024505615): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (797.03330993652): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (470.87669372559): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

153 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

154 (!!!!! 1764.0590667725): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (488.0428314209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

156 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

157 (200.03318786621): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725449 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725449 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (174.99923706055): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (311.85150146484): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (!!!!! 1019.9546813965): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

162 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725449 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725449 AND published='1' LIMIT 1

163 (380.9928894043): select jos_twitters.link from jos_twitters where cat=10

164 (47.922134399414): select jos_facebook.link from jos_facebook where cat=10

165 (138.99803161621): select jos_google_plus.link from jos_google_plus where cat=10

166 (39.100646972656): select jos_linkedin.link from jos_linkedin where cat=10

167 (658.03527832031): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

168 (!!!!! 1183.032989502): insert into jos_banners_delta values (14615,'2025-08-24 07:50:37','216.73.216.171','view'),(14202,'2025-08-24 07:50:37','216.73.216.171','view'),(14203,'2025-08-24 07:50:37','216.73.216.171','view')

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