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Brain Damage Seen on MR Scans May Predict Memory Loss in Old Age

By MedImaging International staff writers
Posted on 31 Aug 2009

Areas of brain damage seen on imaging scans and originally thought to be related to stroke may help clinicians predict an individual's risk of memory problems in old age, according to new findings.

Researchers tested 679 people age 65 and older without dementia for mild cognitive impairment, the stage between normal aging and dementia. Participants underwent magnetic resonance imaging (MRI) brain scanning where the investigators looked for small areas of brain damage called white matter hyperintensities, often referred to as ministrokes. They also looked for infarcts, or areas of dead tissue typically called strokes. Both types of brain damage may be caused by vascular disease in the brain.

The study revealed that individuals with white matter hyperintensities were nearly twice as likely to have mild cognitive impairment that included memory loss. However, individuals who had infarcts on their brain scans were more apt to experience mild cognitive impairment in abilities other than memory loss.

The results remained the same regardless of a person's age, gender, ethnic group, education, and if they had a gene thought to be a strong risk factor for dementia, called the ApoEe4 gene. "The most interesting finding in this study was that white matter hyperintensities, or ministrokes, predicted memory problems, while strokes predicted nonmemory problems,” said study author José Luchsinger, M.D., MPH, from Columbia University Medical Center (New York, USA). "Traditionally, ministrokes and strokes are thought to have a common origin and to more strongly predict nonmemory cognitive problems. There are an increasing number of studies challenging the idea that all white matter hyperintensities are similar to strokes. The fact that white matter hyperintensities more strongly predicted memory problems could challenge traditional views that white matter hyperintensities are milder versions of stroke that are produced only by conditions such as high blood pressure,” said Dr. Luchsinger.

Dr. Luchsinger reported that more research is needed to understand white matter hyperintensities and to identify which are related to stroke and which are related to other conditions such as Alzheimer's disease. He reported that this could eventually help clincians and researchers to design preventive strategies for memory and other types of cognitive impairment.

The study was published in the August 11, 2009, issue of Neurology, the journal of the American Academy of Neurology.

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64 (42.915344238281): select jos_twitters.link from jos_twitters where cat=10

65 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

66 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

67 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

68 (30.040740966797): SELECT fid FROM jos_deeppockets WHERE id=294725214 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294725214 AND published='1' LIMIT 1

69 (56.982040405273): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (322.81875610352): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (266.79039001465): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (70.095062255859): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (68.187713623047): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (35.04753112793): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (50.067901611328): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

105 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

106 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

109 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

110 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (525.95138549805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (653.98216247559): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (419.13986206055): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

115 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

116 (60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

117 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

118 (88.214874267578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

119 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

120 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

121 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

122 (293.01643371582): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 21462.917327881): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (519.99092102051): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725214 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725214 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7954.1206359863): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (155.21049499512): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (67.949295043945): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (322.10350036621): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (470.16143798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (337.83912658691): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=212

138 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=212

139 (767.94624328613): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (645.87593078613): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

142 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

143 (!!!!! 7527.8282165527): TRUNCATE TABLE jos_trademed_module

144 (98.943710327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725214 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (865.93627929688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

149 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

150 (!!!!! 1158.9527130127): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

152 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

153 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725214 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725214 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (35.04753112793): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

158 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725214 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725214 AND published='1' LIMIT 1

159 (39.100646972656): select jos_twitters.link from jos_twitters where cat=10

160 (61.988830566406): select jos_facebook.link from jos_facebook where cat=10

161 (38.14697265625): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

163 (297.06954956055): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (968.93310546875): insert into jos_banners_delta values (14615,'2025-06-29 05:32:17','216.73.216.249','view'),(14202,'2025-06-29 05:32:17','216.73.216.249','view'),(14203,'2025-06-29 05:32:17','216.73.216.249','view')

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