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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Nanoparticles Cross Blood-Brain Barrier Enabling "Brain Tumor Painting”

By MedImaging International staff writers
Posted on 25 Aug 2009

Researchers have been able to illuminate brain tumors by injecting into the bloodstream of mice fluorescent nanoparticles that safely cross the blood-brain barrier. The nanoparticles remained in mouse tumors for up to five days and did not show any evidence of damaging the blood-brain barrier.

Brain cancer is one of the most lethal of cancers. It is also one of the hardest to treat. Imaging results are frequently inexact because brain cancers are extremely invasive. Surgeons must saw through the skull and safely remove as much of the tumor as they can. Then doctors use radiation or chemotherapy to destroy cancerous cells in the surrounding tissue.

The study was conducted by researchers from the University of Washington (UW; Seattle, WA, USA) and published in the August 1, 2009, issue of the journal Cancer Research. The study's findings revealed that the nanoparticles improved the contrast in both magnetic resonance imaging (MRI) and optical imaging, which is used during surgery. "Brain cancers are very invasive, different from the other cancers. They will invade the surrounding tissue and there is no clear boundary between the tumor tissue and the normal brain tissue,” said lead author Dr. Miqin Zhang, a UW professor of materials science and engineering.

Being unable to differentiate a boundary complicates the surgery. Severe cognitive problems are a common side effect. "If we can inject these nanoparticles with infrared dye, they will increase the contrast between the tumor tissue and the normal tissue,” Dr. Zhang said. "So during the surgery, the surgeons can see the boundary more precisely. We call it ‘brain tumor illumination or brain tumor painting.' The tumor will light up.”

Nanoimaging could also help with early cancer detection, according to Dr. Zhang. Current imaging techniques have a maximum resolution of 1 mm; nanoparticles could improve the resolution by a factor of 10 or more, allowing detection of smaller tumors and earlier treatment.

Until now, no nanoparticle used for imaging has been able to cross the blood-brain barrier and specifically bind to brain-tumor cells. With current techniques, clinicians inject dyes into the body and use drugs to temporarily open the blood-brain barrier, risking infection of the brain.

The UW team overcame this hurdle by constructing a nanoparticle that remains small in wet conditions. The particle was about 33 nm in diameter when wet, about one-third the size of similar particles used in other parts of the body.

Crossing the blood-brain barrier depends on the size of the particle, its lipid, or fat, content, and the electric charge on the particle. Dr. Zhang and colleagues built a particle that can pass through the barrier and reach tumors. To specifically target tumor cells they used chlorotoxin, a small peptide isolated from scorpion venom that many groups, including Dr. Zhang's, are examining for its tumor-targeting abilities. On the nanoparticle's surface Zhang placed a small fluorescent molecule for optical imaging, and binding sites that could be used for attaching other molecules.

Future research will evaluate this nanoparticle's potential for treating tumors, according to Dr. Zhang. She and colleagues already demonstrated that chlorotoxin combined with nanoparticles greatly slows tumors' metastasis. They will see whether that ability could extend to brain cancer, the most common solid tumor to affect children.

Merely improving imaging, however, would improve patient outcomes. "Precise imaging of brain tumors is phenomenally important. We know that patient survival for brain tumors is directly related to the amount of tumor that you can resect,” said coauthor Dr. Richard Ellenbogen, professor and chair of neurological surgery at the UW School of Medicine. "This is the next generation of cancer imaging,” he said. "The last generation was CT [computed tomography], this generation was MRI, and this is the next generation of advances.”

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59 (179.05235290527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

60 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

61 (144.95849609375): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (597.95379638672): SELECT fid FROM jos_deeppockets WHERE id=294725133 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294725133 AND published='1' LIMIT 1

63 (377.89344787598): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (72.002410888672): select jos_twitters.link from jos_twitters where cat=10

65 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

66 (33.140182495117): select jos_google_plus.link from jos_google_plus where cat=10

67 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

68 (32.901763916016): SELECT fid FROM jos_deeppockets WHERE id=294725133 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294725133 AND published='1' LIMIT 1

69 (38.862228393555): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (467.06199645996): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725133 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (339.03121948242): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725133 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (59.127807617188): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (94.890594482422): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (70.095062255859): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (86.069107055664): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725133 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (32.186508178711): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725133 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (35.04753112793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (84.161758422852): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

105 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

106 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725133 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (58.174133300781): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725133 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

109 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

110 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725133 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (640.869140625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725133 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (868.08204650879): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (643.96858215332): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (177.86026000977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

115 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

116 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

117 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

118 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

119 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

120 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

121 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

122 (441.07437133789): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 29115.915298462): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (660.18104553223): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725133 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725133 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 10356.903076172): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (111.10305786133): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (423.90823364258): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (84.877014160156): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 2274.0364074707): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (141.85905456543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (632.04765319824): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (78.916549682617): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (354.05158996582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 1799.8218536377): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (603.19900512695): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (386.95335388184): SELECT name FROM jos_deeppockets WHERE id=212

138 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=212

139 (849.96223449707): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (773.90670776367): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

142 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

143 (!!!!! 12058.973312378): TRUNCATE TABLE jos_trademed_module

144 (157.11784362793): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725133 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (91.075897216797): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725133 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (649.92904663086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

149 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

150 (!!!!! 1726.8657684326): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

152 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

153 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725133 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725133 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (46.014785766602): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (53.167343139648): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 2746.8204498291): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

158 (156.16416931152): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725133 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725133 AND published='1' LIMIT 1

159 (88.930130004883): select jos_twitters.link from jos_twitters where cat=10

160 (46.968460083008): select jos_facebook.link from jos_facebook where cat=10

161 (45.061111450195): select jos_google_plus.link from jos_google_plus where cat=10

162 (41.961669921875): select jos_linkedin.link from jos_linkedin where cat=10

163 (500.91743469238): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1478.910446167): insert into jos_banners_delta values (14615,'2025-06-29 08:33:00','216.73.216.249','view'),(14202,'2025-06-29 08:33:00','216.73.216.249','view'),(14203,'2025-06-29 08:33:00','216.73.216.249','view')

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