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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

MRI Brain Map May Reveal Early Mental Illness

By MedImaging International staff writers
Posted on 28 Jul 2009

A researcher is charting the dimensions of the many structures in the human brain. From those measurements--obtained from a magnetic resonance imaging (MRI) scan--the investigator produced a map of the unique dips, swells, and crevasses of the brains of individuals that he hopes will provide the first scientific tool for early and more definite diagnosis of mental disorders such as schizophrenia. Diagnosing the beginning stage of mental disorders, when they are most treatable, remains elusive.

The shapes and measurements of brain structures can reveal how they function. Thus, the investigator hopes his brain maps will reveal how the brains of humans with and without major mental disorders differ from each other and the period over which those differences develop. Diagnosing psychiatric disorders currently is more art than science, according to John Csernansky, M.D., the chair of psychiatry and behavioral sciences at the Northwestern University Feinberg School of Medicine (Chicago, IL, USA) and of psychiatry at the Stone Institute of Psychiatry at Northwestern Memorial Hospital. Unlike a heart attack, for example, which can be identified with an electrocardiogram (ECG) and a blood test for cardiac enzymes, psychiatric illness is diagnosed by asking a patient about his symptoms and history. "That's akin to diagnosing a heart attack by asking people when their pain came and where it was located,” Dr. Csernansky noted. "We would like to have the same kinds of tools that every other field of medicine has.”

To accomplish this goal, Dr. Csernansky is heading a U.S. National Institutes of Mental Health (Bethesda, MD, USA) study to measure the differences between the structure of the schizophrenic and normal brain to be able to more quickly identify schizophrenia in its early stages and see if the medications used to treat the illness halt its devastating advance.

Schizophrenia typically starts in the late teens or early 20s and affects approximately 1% of the population. If the disease is identified early and treated with the most effective antipsychotic medications and psychotherapy, the patient has the best likelihood for recovery. Current treatments are evaluated on whether the patients' symptoms improve over several months. Dr. Csernansky, however, wants to take a longer and broader view. "What we want to know is whether a few years later are you more able to work, are you better able to return to school?” he said. "If you take these medicines for years at a time, is your life better than if you had not taken them? We want to understand the effects of the medicines we give on the biological progression of the disease. We think that's what ultimately determines how well someone does.”

Psychotic and mood disorders are life-long illnesses and require management throughout an individual's life. Dr. Csernansky is recruiting 100 new study participants, half with early-stage schizophrenia and half who are healthy, to map their brain topography and compare the differences and changes over two years. "The brain is very plastic and is constantly remodeling itself. Any changes we see in a disease has to be compared in a background of normal changes of brain structures,” said Dr. Csernansky, who also is the Lizzie Gilman Professor of Psychiatry and Behavioral Sciences.

Dr. Csernansky reported that a brain map of schizophrenia would enable clinicians to make the diagnosis with more confidence as well as catch it earlier. "Like every other illness, psychiatric illnesses don't blossom in their full form overnight. They come on gradually,” he said. "You don't need a biomarker to tell you that you have breast cancer, if you can feel a tumor that is the size of a golf ball. But who wants to discover an illness that advanced? A biomarker of the schizophrenic brain structure would help us define it, especially in cases where the symptoms are mild or fleeting.”

In the past, comparing MRI brain maps was done painstakingly by hand. A technician used a light pen and attempted to trace and manually measure the boundaries of structures in the brain. "It was very laborious and you had to have an expert in your laboratory,” Dr. Csernansky explained. Now he is teaching computers to do the work, speeding the process and enhancing accuracy.

Dr. Csernansky's earlier studies had already shown that the brains of schizophrenic patients have abnormalities in the shape and asymmetry of the hippocampus, a part of the brain that is critical to spatial learning and awareness, navigation and the memory of events. "People with schizophrenia also have problems with interpretation, attention, and controls and thought and memory. So the thalamus is another natural structure to study,” said Dr. Lei Wang, assistant professor of psychiatry and behavioral sciences, and of radiology, at Northwestern's Feinberg School. Dr. Wang works with Csernansky on brain mapping.

Dr. Csernansky commented, "Understanding what changes in brain structure occur very early in the course of schizophrenia and how medication may or may not affect these structures as time goes by will help us reduce the uncertainty of psychiatric diagnosis and improve the selection of treatments.”

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56 (666.14151000977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294724622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1234.0545654297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

58 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

59 (150.91896057129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

60 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

61 (101.08947753906): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (669.00253295898): SELECT fid FROM jos_deeppockets WHERE id=294724622 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294724622 AND published='1' LIMIT 1

63 (384.09233093262): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (61.988830566406): select jos_twitters.link from jos_twitters where cat=10

65 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

66 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

67 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

68 (58.889389038086): SELECT fid FROM jos_deeppockets WHERE id=294724622 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294724622 AND published='1' LIMIT 1

69 (58.889389038086): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (403.88107299805): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294724622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (328.77922058105): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294724622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (51.975250244141): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294724622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (66.995620727539): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294724622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (37.193298339844): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

105 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

106 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294724622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294724622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

109 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

110 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294724622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (554.08477783203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294724622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (647.78327941895): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (551.93901062012): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (166.17774963379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

115 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

116 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

117 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

118 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

119 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

120 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

121 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

122 (325.91819763184): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 21680.116653442): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (571.01249694824): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294724622 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294724622 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7575.9887695312): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (71.048736572266): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (292.06275939941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (34.809112548828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (485.89706420898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (398.87428283691): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (214.81513977051): SELECT name FROM jos_deeppockets WHERE id=212

138 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=212

139 (753.87954711914): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (669.95620727539): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

142 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

143 (!!!!! 20656.824111938): TRUNCATE TABLE jos_trademed_module

144 (165.93933105469): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294724622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (95.129013061523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294724622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (551.93901062012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

149 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

150 (!!!!! 1245.0218200684): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

152 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

153 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294724622 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294724622 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (45.061111450195): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (56.028366088867): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

158 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294724622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294724622 AND published='1' LIMIT 1

159 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

160 (35.04753112793): select jos_facebook.link from jos_facebook where cat=10

161 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

162 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

163 (360.01205444336): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 7400.9895324707): insert into jos_banners_delta values (14615,'2025-06-29 06:39:39','216.73.216.249','view'),(14202,'2025-06-29 06:39:39','216.73.216.249','view'),(14203,'2025-06-29 06:39:39','216.73.216.249','view')

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