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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

MRI Method Diagnoses Osteoarthritis in its Earliest Stages

By MedImaging International staff writers
Posted on 15 Sep 2008

Newly developed medical imaging technology may provide clinicians with a long-awaited test for early diagnosis of osteoarthritis (OA).

Scientists from New York University (New York, NY, USA) presented their findings August 21, 2008, at the 236th National meeting of the American Chemical Society, held in New York, NY, USA. By far the most common form of arthritis, OA causes joint pain and disability for more than half of those over 65--nearly 21 million individuals in the United States.

Current diagnostic methods usually do not detect the disease until OA is in advanced stages when joint damage may already have occurred. A method for early diagnosis could open a window of opportunity for preventing or reducing permanent damage, particularly with evidence that dietary supplements such as glucosamine and chondroitin can stop additional joint degeneration, according to Alexej Jerschow, Ph.D., who reported on the research jointly with Ravinder R. Regatte, Ph.D.

"Our methods have the potential of providing early warning signs for cartilage disorders like osteoarthritis, thus potentially avoiding surgery and physical therapy later on,” stated Dr. Jerschow. "Also, the effectiveness of early preventative drug therapies can be better assessed with these methods.”

Especially common in the knee and hip, osteoarthritis damages cartilage, the tough, elastic material that cushions moving parts of joints. OA is the most typical reason for total hip and total knee replacement surgery. "It has all these painful consequences and makes it difficult to move--it results in a severe loss of quality of life for those who are affected by it,” stated Dr. Regatte.

The new imaging modality uses a modified form of magnetic resonance imaging (MRI) to determine the concentration of a polymer known as glycosaminoglycan (GAG), which holds lots of water and gives cartilage its tough, elastic properties. GAG also is a recognized biomarker for both osteoarthritis and degenerative disc disease--a common cause of back pain. According to Dr. Jerschow, a low concentration of GAG is known to correlate with the onset of osteoarthritis and other cartilage disorders.

The diagnostic agent "tags” the hydrogen atoms attached to the GAGs in a manner that makes them emit a signal that can captured up by a MRI machine to determine the concentration of GAG and assess cartilage health. Advanced OA is very easy to diagnose, Dr. Regatte pointed out. By then, however, joint replacement may be the only option. With early detection, physicians could prescribe dietary supplements, medication, or other measures to ward off further cartilage damage. "Given the lack of knowledge about OA, I think any method that is noninvasive and relatively easy to apply will be quite valuable. Not only do you address diagnosis, but you address how we can understand OA's mechanism,” said Dr. Jerschow.

The MRI scan could also be used to improve existing cartilage-enhancing drugs, according to Dr. Regatte. At present, it is difficult to assess the effectiveness of these drugs without a diagnostic tool to gauge their effects on cartilage. "There are drugs on the market for OA treatment, but no one really knows how effective they are. After having done the research, we got a lot of calls from pharmaceutical companies wanting to show that their drugs work,” remarked Dr. Jerschow.

The cost and time it takes for the cartilage test is about the same as a typical MRI, according to Dr. Regatte. Diagnosis could be given on a same day basis. "I really hope it will develop into the gold standard technique,” said Dr. Jerschow. "I'm pretty confident in saying that its one of the better methods out there for testing cartilage health.”

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59 (143.05114746094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

60 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

61 (311.13624572754): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (514.03045654297): SELECT fid FROM jos_deeppockets WHERE id=294720350 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294720350 AND published='1' LIMIT 1

63 (!!!!! 5861.0439300537): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (107.0499420166): select jos_twitters.link from jos_twitters where cat=10

65 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

66 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

67 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

68 (48.160552978516): SELECT fid FROM jos_deeppockets WHERE id=294720350 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294720350 AND published='1' LIMIT 1

69 (50.067901611328): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (430.82237243652): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720350 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (431.06079101562): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720350 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (97.036361694336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (106.8115234375): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (940.79971313477): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720350 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (80.82389831543): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720350 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (51.975250244141): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (90.837478637695): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 2551.0787963867): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (78.916549682617): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (120.87821960449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

105 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

106 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720350 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (126.12342834473): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720350 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (447.03483581543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

109 (!!!!! 1957.1781158447): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

110 (92.029571533203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720350 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (630.14030456543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720350 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (748.87275695801): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (409.12628173828): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 2104.9976348877): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

115 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

116 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

117 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

118 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

119 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

120 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

121 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

122 (416.99409484863): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 49054.861068726): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (674.96299743652): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720350 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720350 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 16461.133956909): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (89.168548583984): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (69.856643676758): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (50.783157348633): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (432.96813964844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (98.943710327148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (634.90867614746): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (550.0316619873): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (55.074691772461): SELECT name FROM jos_deeppockets WHERE id=212

138 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=212

139 (905.99060058594): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (732.8987121582): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 2736.0916137695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

142 (114.20249938965): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

143 (!!!!! 20559.072494507): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 2737.0452880859): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720350 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (141.14379882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720350 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (590.08598327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

149 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

150 (!!!!! 4533.052444458): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

152 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

153 (63.896179199219): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720350 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720350 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (48.160552978516): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (39.815902709961): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (44.107437133789): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

158 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720350 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720350 AND published='1' LIMIT 1

159 (!!!!! 2068.042755127): select jos_twitters.link from jos_twitters where cat=10

160 (68.902969360352): select jos_facebook.link from jos_facebook where cat=10

161 (52.213668823242): select jos_google_plus.link from jos_google_plus where cat=10

162 (39.100646972656): select jos_linkedin.link from jos_linkedin where cat=10

163 (382.90023803711): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1333.9519500732): insert into jos_banners_delta values (14615,'2025-06-30 08:37:00','216.73.216.249','view'),(14202,'2025-06-30 08:37:00','216.73.216.249','view'),(14203,'2025-06-30 08:37:00','216.73.216.249','view')

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