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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Hyper-CEST MRI Technique Is Much Faster, More Selective

By MedImaging staff writers
Posted on 03 Jun 2008

Conventional magnetic resonance imaging (MRI) is an outstanding diagnostic tool but one that suffers from low sensitivity, requiring patients to remain motionless for long periods inside noisy, claustrophobic machines. A promising new MRI method, much faster, more selective in that it is able to distinguish even among specific target molecules, and many thousands of times more sensitive, has now been developed.

The key to the new technique is called temperature-controlled molecular depolarization gates. It is based on a series of previous developments in MRI and the closely related field of nuclear magnetic resonance (NMR, which instead of an image yields a spectrum of molecular information) by members of the laboratories of Drs. Alexander Pines and David Wemmer at the U.S. Department of Energy's (DOE) Lawrence Berkeley National Laboratory (Berkeley, CA, USA) and the University of California at Berkeley (USA).

The technique was developed by a team of past and present Pines and Wemmer lab members headed by Dr. Leif Schröder of Berkeley Lab's Materials Sciences Division and including Drs. Lana Chavez, Tyler Meldrum, Monica Smith, and Thomas Lowery. The researchers outlined their results in May 2008 in the online international issue of the journal Angewandte Chemie.

"The new method holds the promise of combining a set of proven NMR tools for the first time into a practical, supersensitive diagnostic system for imaging the distribution of specific molecules on such targets as tumors in human subjects,” said lead author Dr. Schröder, "or even on individual cancer cells.”

Xenon is particularly useful in MRI and NMR because the spins of its nuclei are readily polarized, in a process involving contact with rubidium vapor irradiated with a laser beam. In such "hyperpolarized” xenon, the excess of spin-up nuclei can be as much as 20%, which gives a far stronger signal than hydrogen's 0.001% spin-up excess. Moreover, hyperpolarized xenon has a much longer relaxation time than hydrogen.

The final advance underlying the new technique is called Hyper-CEST: hyperpolarized xenon chemical-exchange saturation transfer. While biosensors can bring the xenon to specific molecular targets, in realistic applications relatively few of these are present, only about one percent compared to the total amount of free xenon injected near that target. The signal from the polarized xenon inside the biosensor cages is consequently much fainter than that from the uncaged polarized xenon nearby.

The trick then is to depolarize the xenon nuclei in the immediate vicinity of the cages, which will serve to outline the target in high contrast against the surrounding hyperpolarized xenon pool. This is done through chemical exchange, as xenon atoms are constantly entering and leaving the biosensor cages.

Because it produces a much stronger signal, Hyper-CEST acquires images thousands of times faster than imaging the caged xenon directly would. Yet, it retains the great advantages of cryptophane biosensors, including their ability to "multiplex,” or detect different targets at the same time.

Hyper-CEST at a range of temperatures has many advantages. Most basic is that biomedical MRI must operate at body temperature. Aside from this practical consideration, temperature determines the rates at which different kinds of cryptophane-cage hosts react with their xenon-atom guests. Moreover, increasing temperature dramatically increases chemical exchange rates.

Related Links:
Lawrence Berkeley National Laboratory
University of California at Berkeley

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61 (133.03756713867): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (656.1279296875): SELECT fid FROM jos_deeppockets WHERE id=284300000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=284300000 AND published='1' LIMIT 1

63 (429.86869812012): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (58.174133300781): select jos_twitters.link from jos_twitters where cat=10

65 (36.001205444336): select jos_facebook.link from jos_facebook where cat=10

66 (36.954879760742): select jos_google_plus.link from jos_google_plus where cat=10

67 (33.855438232422): select jos_linkedin.link from jos_linkedin where cat=10

68 (37.908554077148): SELECT fid FROM jos_deeppockets WHERE id=284300000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=284300000 AND published='1' LIMIT 1

69 (40.054321289062): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (361.91940307617): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=284300000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (405.07316589355): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=284300000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (66.041946411133): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (54.121017456055): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=284300000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (32.901763916016): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=284300000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (40.054321289062): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (76.055526733398): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (72.956085205078): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

105 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

106 (75.817108154297): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=284300000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=284300000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

109 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

110 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=284300000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (627.04086303711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=284300000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (533.10394287109): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (320.9114074707): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

115 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

116 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

117 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

118 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

119 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

120 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

121 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

122 (283.95652770996): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 19699.096679688): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (607.01370239258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=284300000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=284300000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7796.049118042): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (76.055526733398): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (318.05038452148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (305.17578125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (211.00044250488): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (248.19374084473): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (426.05400085449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (370.97930908203): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (185.96649169922): SELECT name FROM jos_deeppockets WHERE id=212

138 (30.994415283203): SELECT name FROM jos_deeppockets WHERE id=212

139 (528.09715270996): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (475.88348388672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (134.94491577148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

142 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

143 (!!!!! 14556.884765625): TRUNCATE TABLE jos_trademed_module

144 (355.00526428223): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=284300000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (694.03648376465): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=284300000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (326.87187194824): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

149 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

150 (!!!!! 1138.9255523682): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

152 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

153 (48.87580871582): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=284300000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=284300000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (37.908554077148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (48.160552978516): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

158 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=284300000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=284300000 AND published='1' LIMIT 1

159 (101.08947753906): select jos_twitters.link from jos_twitters where cat=10

160 (27.179718017578): select jos_facebook.link from jos_facebook where cat=10

161 (27.179718017578): select jos_google_plus.link from jos_google_plus where cat=10

162 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

163 (224.11346435547): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1690.8645629883): insert into jos_banners_delta values (14615,'2025-06-30 16:40:48','216.73.216.249','view'),(14202,'2025-06-30 16:40:48','216.73.216.249','view'),(14203,'2025-06-30 16:40:48','216.73.216.249','view')

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