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Neuroimaging Reveals Biologic Basis of Cocaine Addiction

By MedImaging staff writers
Posted on 17 Mar 2008

Researchers looking at the brain activity of cocaine users may have identified a biologic ‘lack of willpower' that should help researchers understand why some individuals become long-term addicts whereas others can use the drug socially.

The investigators presented their findings at a scientific meeting at the Royal Society (London, UK), the UK's National Academy of Science, on February 26, 2008. By taking brain scans of cocaine users while they performed computer tasks that assessed both impulsive behavior and the brain's response to making a ‘mistake,' scientists from Trinity College Dublin (Ireland) have been able to identify the precise regions of the brain affected by cocaine. The investigators utilized functional magnetic resonance imaging (fMRI), a noninvasive imaging modality to show that cocaine alters the areas of the brain responsible for controlling behavior, and making appropriate decisions.

Dr. Hugh Garavan, lead researcher on the project, said, "Non-invasive brain imaging allows us to study the biology behind ‘willpower,' which until now, most people would think of as something that cannot be measured ‘objectively' using scientific investigation. This research helps us move away from thinking of drug dependence as a moral weakness and allows us to see it as more of a medical condition. Research into drug abuse has tended to focus on the emotional aspects of addiction, such as pleasure seeking, craving, and withdrawal. However, by using brain scans to study ‘impulse control,' the brain's ability to control a person's actions, we can see the direct effects that cocaine has on the brain's ability to control behavior.”

Dr. Garavan presented his research at a Royal Society discussion meeting on February 25, and 26, 2008. "Cocaine's effect on this impulse control may account for why some users find it easier to quit than others. In the future this may lead to an understanding of why some people develop long term addictions to cocaine and others don't,” Dr. Garavan additionally stated. "Understanding the role that our brain plays in addiction may also have important implications for treating long-term addiction and designing intervention therapies. Importantly, new medication based on certain chemical processes in the brain could be developed; as currently there are no good pharmacological treatments for cocaine. Traditional treatment therapy such as counseling or rehab could also be adapted to train addicts to monitor their behavior and practice impulse control.”

Dr Garavan's study also demonstrated that there are differences in the brain structures of cocaine users. This has significant consequences for how society perceives and treats addicted users. Dr Garavan noted, "It is still unclear whether the differences we see in cocaine users' brains existed before they began taking cocaine or whether they are a result of use, or both. It is more a case of trying to understand as much as possible about the underlying brain function of addicts. One would hope this research would guide the development of new treatments including the development of pharmacological solutions to addiction.”

The Royal Society is an independent academy promoting the natural and applied sciences. Founded in 1660, the Society has three roles, as the UK Academy of Science, as a learned Society, and as a funding agency.

Related Links:
Royal Society
Trinity College Dublin

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60 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

61 (!!!!! 4895.9255218506): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 2714.8723602295): SELECT fid FROM jos_deeppockets WHERE id=274820000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=274820000 AND published='1' LIMIT 1

63 (!!!!! 2835.0353240967): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (!!!!! 1464.1284942627): select jos_twitters.link from jos_twitters where cat=10

65 (!!!!! 4993.9155578613): select jos_facebook.link from jos_facebook where cat=10

66 (729.08401489258): select jos_google_plus.link from jos_google_plus where cat=10

67 (43.153762817383): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 2936.840057373): SELECT fid FROM jos_deeppockets WHERE id=274820000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=274820000 AND published='1' LIMIT 1

69 (478.98292541504): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (778.9134979248): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=274820000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 3699.0642547607): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=274820000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 7194.995880127): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (340.93856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (134.22966003418): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (186.92016601562): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (347.85270690918): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (201.94053649902): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (117.06352233887): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (173.09188842773): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (349.99847412109): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=274820000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (44.822692871094): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=274820000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (180.00602722168): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (116.10984802246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

105 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

106 (78.201293945312): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=274820000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=274820000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (160.93254089355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

109 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

110 (!!!!! 2213.9549255371): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=274820000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (591.03965759277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=274820000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (751.01852416992): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (576.97296142578): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (130.17654418945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

115 (88.214874267578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

116 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

117 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

118 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

119 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

120 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

121 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

122 (391.96014404297): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 76812.028884888): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (701.904296875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=274820000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=274820000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 24448.156356812): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (81.062316894531): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (659.94262695312): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (57.93571472168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (498.05641174316): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (465.86990356445): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (327.82554626465): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (!!!!! 1242.1607971191): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (545.97854614258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (413.89465332031): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (234.12704467773): SELECT name FROM jos_deeppockets WHERE id=212

138 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=212

139 (747.9190826416): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (651.83639526367): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 5757.8086853027): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

142 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

143 (!!!!! 16282.081604004): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1182.0793151855): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=274820000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 1014.9478912354): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=274820000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (451.08795166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

149 (375.03242492676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

150 (!!!!! 6062.0307922363): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (273.9429473877): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

152 (612.97416687012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

153 (38.14697265625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=274820000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=274820000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (32.186508178711): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (442.0280456543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

158 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=274820000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=274820000 AND published='1' LIMIT 1

159 (!!!!! 1469.1352844238): select jos_twitters.link from jos_twitters where cat=10

160 (65.803527832031): select jos_facebook.link from jos_facebook where cat=10

161 (47.922134399414): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

163 (358.10470581055): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1010.1795196533): insert into jos_banners_delta values (14615,'2025-07-01 03:54:38','216.73.216.249','view'),(14202,'2025-07-01 03:54:38','216.73.216.249','view'),(14203,'2025-07-01 03:54:38','216.73.216.249','view')

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