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MRI Techniques Provides Better Evaluation of Liver Fibrosis

By MedImaging staff writers
Posted on 21 Jan 2008

Magnetic resonance imaging (MRI) imagery is emerging as a non-invasive way to determine the existence and extent of hepatic fibrosis. It could ultimately help the development of pharmacologic strategies to treat the condition.

Currently, the best method to evaluate hepatic fibrosis is liver biopsy; however, it is an invasive procedure that can cause serious side effects. Researchers have been assessing less invasive techniques such as blood tests, and imaging strategies such as ultrasound, but up to now, they have not proven sensitive enough to detect the various stages of fibrosis.

Over the past decade, a number of technologic advances have been made in MRI of the liver. Researchers led by Dr. Jayant Talwalkar, from the Mayo Clinic (Rochester, MN, USA), examined the current state of MR imaging and the studies that looked at its utility in detecting liver fibrosis. They discovered that contrast-enhanced MRI, MR spectroscopy, and diffusion-weighted MRI have shown promise for detecting hepatic fibrosis, although they require further modifications.

However, the technology that is showing the greatest promise is MR elastography, which quantitatively assesses tissue stiffness. Recent studies have shown that MR elastography has high sensitivity and specificity in detecting fibrosis stages. "As with other techniques, efforts to standardize the equipment and techniques used for MR elastography should be pursued to maximize diagnostic accuracy and facilitate comparison of results in different settings,” the authors suggested. "Reproducibility appears good from initial studies but requires additional study for verification.”

The investigators emphasized that the design and conduct of high-quality diagnostic accuracy studies are vital for ongoing validation of these emerging non-invasive techniques for determining hepatic fibrosis. Most relevant studies to date have included small numbers of patients and lacked independent assessment, issues that should be addressed in future studies.

Once MRI techniques have become suitably refined, patients will likely prefer them to liver biopsy. While the number of patients screened for hepatic fibrosis may increase using MR imaging, proof will be required that early detection and intervention can reduce morbidity and resource utilization associated with the clinical sequelae of advanced disease, the authors pointed out.

"The development of a reliable and valid non-invasive method to assess hepatic fibrosis could result in comparable or, perhaps, improved accuracy in terms of staging,” the researchers concluded. "The emergence of MR imaging techniques [singly or in combination with other methods] could result in the performance of true functional hepatic imaging.”

The study was published in the January 2008 issue of the journal Hepatology.

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66 (32.901763916016): select jos_google_plus.link from jos_google_plus where cat=10

67 (33.140182495117): select jos_linkedin.link from jos_linkedin where cat=10

68 (34.093856811523): SELECT fid FROM jos_deeppockets WHERE id=268550000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=268550000 AND published='1' LIMIT 1

69 (36.954879760742): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (293.01643371582): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=268550000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (225.06713867188): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=268550000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (44.107437133789): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=268550000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.994415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=268550000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (35.04753112793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

105 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

106 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=268550000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=268550000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

109 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

110 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=268550000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (483.03604125977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=268550000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (574.82719421387): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (326.87187194824): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

115 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

116 (116.10984802246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

117 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

118 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

119 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

120 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

121 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

122 (319.9577331543): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 22630.929946899): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (478.02925109863): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=268550000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=268550000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 6994.0090179443): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (87.976455688477): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (267.98248291016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (63.896179199219): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (197.8874206543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (176.90658569336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (200.98686218262): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (480.89027404785): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (334.02442932129): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (191.92695617676): SELECT name FROM jos_deeppockets WHERE id=212

138 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=212

139 (553.84635925293): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (452.99530029297): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

142 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

143 (!!!!! 8334.1598510742): TRUNCATE TABLE jos_trademed_module

144 (139.95170593262): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=268550000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (76.055526733398): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=268550000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (795.12596130371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

149 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

150 (!!!!! 1056.9095611572): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

152 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

153 (37.908554077148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=268550000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=268550000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (389.09912109375): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (66.995620727539): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

158 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=268550000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=268550000 AND published='1' LIMIT 1

159 (163.07830810547): select jos_twitters.link from jos_twitters where cat=10

160 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

161 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

162 (25.033950805664): select jos_linkedin.link from jos_linkedin where cat=10

163 (234.84230041504): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1446.008682251): insert into jos_banners_delta values (14615,'2025-07-01 01:59:08','216.73.216.249','view'),(14202,'2025-07-01 01:59:08','216.73.216.249','view'),(14203,'2025-07-01 01:59:08','216.73.216.249','view')

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