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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

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Ultrasound Equipment
Trademed.com is our new marketplace where you will find ultrasound devices and equipment for hospitals and clinics.

New Contrast Agent for Ultrasound Imaging Ensures Affordable and Safer Medical Diagnostics

By MedImaging International staff writers
Posted on 22 Jan 2025

Image: Experimental design of the study (Photo courtesy of Tatiana Estifeeva et al./Biomaterials Advances)

Ultrasound imaging is an affordable and non-invasive diagnostic method that uses widely available equipment. However, its results are often not highly accurate, and the image quality is heavily dependent on the operator's skill. In contrast, techniques like MRI and CT scans are not always accessible due to their high cost, lack of available equipment, and potential harm caused by the contrast agents used in these methods. These contrast agents are toxic, and CT scans expose patients to high radiation doses. On the other hand, ultrasound imaging with contrast agents can significantly improve the quality of images for internal organs, such as the heart, liver, and brain. This enhanced ultrasound technique could be useful for diagnosing a wide array of diseases in the cardiovascular, liver, kidney, and female reproductive systems. Ultrasound contrast agents are often microbubbles made from proteins, lipids, or polymers. Proteins enhance image quality, while lipids and polymers provide stability, extending the time available for diagnostics. Despite these benefits, further improvements in their performance are still needed.

Researchers at Skolkovo Institute of Science and Technology (Skoltech, Moscow, Russia) have developed and tested protein-polymer microbubbles for medical ultrasound imaging. When injected intravenously, these microbubbles serve as contrast agents, improving image quality. Tested in rats, the new microbubbles stayed in the bloodstream longer than the currently available alternatives, giving doctors more time to complete the examination. This enhanced contrast could make ultrasound a viable alternative to MRI and CT scans, which are more expensive and potentially harmful. The researchers created the first "hybrid" microbubble formulation by combining a protein called albumin with a copolymer.

This formulation resulted in 100 different microbubble types for ultrasound imaging, from which the most effective contrast agent was chosen and tested on a rat’s beating heart. The selection process involved multiple steps: evaluating microbubble size, concentration, and acoustic response in organ phantoms and animals. Compared to a protein-based agent without the added copolymer, the hybrid microbubbles showed significant improvements in both image contrast and the time they remained in the bloodstream, which was one and a half to two times longer.

To create the new contrast agent, the team combined bovine serum albumin—a commonly used protein in pharmacology, including in microbubble production—with biocompatible polymers. They tested 100 different combinations, varying the type of polymer and the polymer's proportion in the mixture from 2% to nearly 50%. The challenge was to find the right balance between microbubble stability, concentration, and ultrasound response. Formulations that did not produce stable microbubbles were discarded, and the remaining candidates were tested on a blood vessel phantom to measure bubble size, concentration, and acoustic response. This process led to the identification of the most promising formulation, which was then compared with pure albumin microbubbles and a saline injection in animal trials.

In these tests, the contrast agent was injected into a rat’s tail vein, followed by an ultrasound exam of its heart. The results, published in Biomaterials Advances, revealed that while the image without contrast showed few details, and the image with the protein contrast only displayed the ventricles, the hybrid agent provided a clear view of the entire four-chamber heart. Moreover, the effect lasted up to 7 minutes, compared to just 3 minutes with standard agents. The researchers believe the new agent’s high contrast could make it a valuable tool for diagnosing infertility in women and studying blood vessels in the brain, although further work is needed to fully explore its potential.

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75 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (72.956085205078): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

91 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

92 (113.01040649414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803784 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

94 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

95 (301.12266540527): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803784 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (443.93539428711): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (378.84712219238): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

99 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

100 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

101 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

102 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

103 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

104 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

105 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

106 (295.87745666504): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 78069.925308228): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (!!!!! 3592.9679870605): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803784 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803784 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 14324.188232422): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (296.83113098145): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (!!!!! 1537.0845794678): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (99.18212890625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (!!!!! 5260.9443664551): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (84.877014160156): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (300.88424682617): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (222.92137145996): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (495.91064453125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (174.99923706055): SELECT name FROM jos_deeppockets WHERE id=214

121 (73.909759521484): SELECT name FROM jos_deeppockets WHERE id=214

122 (696.18225097656): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (701.904296875): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

125 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

126 (!!!!! 10734.081268311): TRUNCATE TABLE jos_trademed_module

127 (512.83836364746): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803784 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (!!!!! 2164.8406982422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (176.90658569336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

131 (290.87066650391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

132 (!!!!! 1529.9320220947): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

134 (254.15420532227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

135 (519.99092102051): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803784 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803784 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (!!!!! 1183.032989502): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

137 (975.8472442627): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

138 (!!!!! 1679.8973083496): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (195.98007202148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

140 (277.04238891602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803784 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803784 AND published='1' LIMIT 1

141 (129.93812561035): select jos_twitters.link from jos_twitters where cat=10

142 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

143 (27.179718017578): select jos_google_plus.link from jos_google_plus where cat=10

144 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

145 (273.9429473877): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

146 (930.0708770752): insert into jos_banners_delta values (14202,'2025-06-21 04:49:13','216.73.216.120','view'),(14203,'2025-06-21 04:49:13','216.73.216.120','view')

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