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Ultrasound-Directed Microbubbles Boost Immune Response Against Tumors

By MedImaging International staff writers
Posted on 17 Jan 2025

Image: The novel method of fighting cancer can stimulate critical cytokine secretion in T cells

A significant challenge in cancer treatment is the tumor's ability to suppress the immune system, particularly by deactivating T cells that enter the tumor. Once inside, the tumor can inhibit T cells from producing crucial cytokines and other proteins that are essential for the body’s immune response. To address this, researchers have proposed a novel method using ultrasound-guided microbubbles—a technology commonly utilized in medical imaging and drug delivery—to enhance T-cell activity by increasing their cell permeability.

A team of researchers from Concordia University (Montreal, QC, Canada) explored how ultrasound-guided microbubbles can influence the release of over 90 different cytokines, which are signaling molecules vital for the immune response. By targeting freshly isolated human immune cells with focused ultrasound beams and clinically approved contrast agent microbubbles, they created a "push-pull" effect on the T cell membranes. This vibration, caused by the high-frequency ultrasound, mimics the T cell’s natural reaction to encountering an antigen, which in turn prompts the T cell to release essential cytokines. These cytokines are typically restricted by the hostile tumor environment, but this process increases their secretion without damaging the T cells themselves.

The study, published in Frontiers in Immunology, revealed that the changes in cytokine secretion were time-dependent. The cytokine levels increased by a factor of 0.1 to 3.6 compared to untreated cells over a 48-hour period. However, the researchers also noted that when the ultrasound made the T cell membranes more permeable, the amount of cytokines released tended to decrease. Although the findings are preliminary, based on benchtop experiments, the researchers hope this study will provide deeper insights into the immune system’s chemical pathways in fighting cancer. Furthermore, they believe this approach could enhance and complement existing cancer treatments, offering new avenues for improving cellular therapies.

“We’re combining the use of ultrasound and microbubbles to help modulate brain immunology with the emerging field of cancer immunotherapy, which is the harnessing of our own immune cells to fight cancer,” said Brandon Helfield, an associate professor of biology and physics and the paper’s supervising author. “We already use microbubbles clinically as image-guided tools. In the future, we could manipulate the beam to go from imaging to a therapeutic sequence. This would localize the effect on the T cells so you are only activating the ones where the beam is.”

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84 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (536.91864013672): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (192.88063049316): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (!!!!! 2440.9294128418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

91 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

92 (610.1131439209): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803744 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (131.84547424316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

94 (365.01884460449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

95 (527.14347839355): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803744 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (519.99092102051): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (313.99726867676): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

99 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

100 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

101 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

102 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

103 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

104 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

105 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

106 (248.90899658203): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 19267.082214355): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (504.97055053711): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803744 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803744 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 7933.8550567627): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (94.890594482422): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (278.94973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (197.8874206543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (180.00602722168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (301.83792114258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (133.99124145508): SELECT name FROM jos_deeppockets WHERE id=214

121 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=214

122 (555.99212646484): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (434.16023254395): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

125 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

126 (!!!!! 3533.1249237061): TRUNCATE TABLE jos_trademed_module

127 (84.161758422852): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803744 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (509.02366638184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

131 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

132 (!!!!! 1134.8724365234): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

134 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

135 (33.140182495117): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803744 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803744 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (38.862228393555): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

137 (29.087066650391): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

138 (31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

140 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803744 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803744 AND published='1' LIMIT 1

141 (106.0962677002): select jos_twitters.link from jos_twitters where cat=10

142 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

143 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

144 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

145 (276.08871459961): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

146 (928.87878417969): insert into jos_banners_delta values (14202,'2025-06-21 04:39:24','216.73.216.120','view'),(14203,'2025-06-21 04:39:24','216.73.216.120','view')

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