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Medical Imaging Breakthrough to Revolutionize Cancer and Arthritis Diagnosis

By MedImaging International staff writers
Posted on 03 Oct 2024

Image: Disease captured by the hand-held 3D photoacoustic scanner (Photo courtesy of Dr. Nam Huynh)

Photoacoustic tomography (PAT) imaging uses laser-generated ultrasound waves to detect subtle changes in small veins and arteries, typically less than a millimeter in size and up to 15mm deep in human tissues. However, traditional PAT technology has been too slow to produce high-quality 3D images suitable for clinical use. During a PAT scan, patients must remain completely still, and any movement during the slow scan can blur images, reducing their clinical value. Now, a new handheld scanner has been developed that can generate highly detailed 3D photoacoustic images in just seconds. This breakthrough opens the door for the use of PAT in clinical settings for the first time, potentially allowing earlier diagnosis of diseases. Conventional PAT scanners take more than five minutes to capture an image. By reducing the scanning time to a few seconds, the new technology improves image quality and makes the process much more practical for frail or unwell patients.

In the study, published in Nature Biomedical Engineering, the research team at University College London (London, UK) demonstrated that their new technology can deliver PAT imaging scans in real-time. This provides clinicians with accurate and detailed images of blood vessels, enhancing patient care. The team suggests that pending further testing, the scanner could help diagnose conditions such as cancer, cardiovascular disease, and arthritis within three to five years. The major breakthrough in this study is the dramatic reduction in imaging time, which is 100 to 1,000 times faster than previous PAT scanners. This speed prevents motion-induced blurring, enabling the production of highly detailed images of a quality unmatched by other scanners. The ability to acquire images in real time also makes it possible to observe dynamic physiological events. These advancements make the system suitable for clinical use, allowing doctors to examine aspects of human biology and disease that were previously inaccessible.

One key potential application for the new scanner is in the assessment of inflammatory arthritis, which requires scanning all 20 finger joints in both hands. The new scanner can perform this task in just a few minutes, compared to nearly an hour with older PAT scanners—an impractical time frame for elderly or frail patients. During pre-clinical testing, the team used the scanner on 10 patients with type-2 diabetes, rheumatoid arthritis, or breast cancer, as well as seven healthy volunteers. In three patients with type-2 diabetes, the scanner produced detailed 3D images of the microvasculature in their feet, revealing deformities and structural changes in the vessels. The scanner was also used to visualize skin inflammation related to breast cancer.

For conditions like peripheral vascular disease (PVD), a diabetes-related complication, early changes in tiny blood vessels are often invisible with conventional imaging techniques such as MRI. However, PAT can detect these early signs, offering the potential for earlier treatment to prevent tissue damage, poor wound healing, and the need for amputation. PVD affects more than 25 million people across the US and Europe. Similarly, in cancer cases, tumors often have a dense network of small blood vessels that are too small to detect with other imaging methods. PAT could be used to detect tumors and monitor their development more effectively. It may also assist surgeons in distinguishing tumor tissue from healthy tissue by visualizing the tumor's blood vessels, helping ensure complete removal during surgery and reducing the risk of recurrence. A key advantage of PAT technology is its sensitivity to hemoglobin, a light-absorbing molecule that produces ultrasound waves, making it especially effective in detecting blood vessels.

“One of the complications often suffered by people with diabetes is low blood flow in the extremities, such as the feet and lower legs, due to damage to the tiny blood vessels in these areas. But until now we haven’t been able to see exactly what is happening to cause this damage or characterize how it develops,” said Andrew Plumb, Associate Professor of Medical Imaging at UCL and consultant radiologist at UCLH and a senior author of the study. “In one of our patients, we could see smooth, uniform vessels in the left foot and deformed, squiggly vessels in the same region of the right foot, indicative of problems that may lead to tissue damage in future. Photoacoustic imaging could give us much more detailed information to facilitate early diagnosis, as well as better understand disease progression more generally.”

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57 (303.98368835449): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

58 (154.97207641602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1101.016998291): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

60 (!!!!! 3367.1855926514): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

61 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

62 (!!!!! 2524.8527526855): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

63 (149.96528625488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

64 (!!!!! 3195.04737854): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (!!!!! 1041.8891906738): SELECT fid FROM jos_deeppockets WHERE id=294802639 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294802639 AND published='1' LIMIT 1

66 (!!!!! 5238.0561828613): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

67 (525.95138549805): select jos_twitters.link from jos_twitters where cat=10

68 (38.862228393555): select jos_facebook.link from jos_facebook where cat=10

69 (160.93254089355): select jos_google_plus.link from jos_google_plus where cat=10

70 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

71 (170.94612121582): SELECT fid FROM jos_deeppockets WHERE id=294802639 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294802639 AND published='1' LIMIT 1

72 (242.94853210449): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

73 (847.81646728516): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (669.00253295898): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (61.988830566406): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (!!!!! 3226.9954681396): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (242.94853210449): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (158.07151794434): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (159.97886657715): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (211.95411682129): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (164.03198242188): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (378.84712219238): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (131.13021850586): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (162.83988952637): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (!!!!! 1147.0317840576): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (118.97087097168): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (69.141387939453): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (126.12342834473): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 1806.9744110107): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (120.87821960449): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (180.00602722168): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (181.91337585449): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (64.849853515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (648.97537231445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

108 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

109 (!!!!! 1266.9563293457): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (923.87199401855): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (562.19100952148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

112 (195.02639770508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

113 (56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (530.95817565918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (!!!!! 1255.989074707): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (626.0871887207): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (769.13833618164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

118 (183.8207244873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

119 (149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

120 (477.07557678223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

121 (370.97930908203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

122 (149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

123 (98.228454589844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

124 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

125 (463.00888061523): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 58495.998382568): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (622.98774719238): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802639 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802639 AND type='deeppockets_item' AND published='1' LIMIT 1

128 (142.81272888184): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (51.021575927734): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (87.976455688477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (69.856643676758): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (40.769577026367): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (59.843063354492): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (500.91743469238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (422.95455932617): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (174.99923706055): SELECT name FROM jos_deeppockets WHERE id=214

141 (38.862228393555): SELECT name FROM jos_deeppockets WHERE id=214

142 (661.13471984863): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (823.02093505859): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (120.87821960449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

145 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

146 (!!!!! 8125.7820129395): TRUNCATE TABLE jos_trademed_module

147 (152.1110534668): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (441.07437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

152 (962.97264099121): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

153 (!!!!! 1743.7934875488): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

155 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

156 (59.127807617188): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802639 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802639 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

158 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

159 (40.054321289062): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (232.93495178223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

161 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802639 AND published='1' LIMIT 1

162 (82.969665527344): select jos_twitters.link from jos_twitters where cat=10

163 (39.815902709961): select jos_facebook.link from jos_facebook where cat=10

164 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

165 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10

166 (360.01205444336): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

167 (!!!!! 1016.8552398682): insert into jos_banners_delta values (14202,'2025-08-02 15:20:20','216.73.216.210','view'),(14203,'2025-08-02 15:20:20','216.73.216.210','view')

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