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Implantable Ultrasound Device Could Replace Electrodes for Deep Brain Stimulation

By MedImaging International staff writers
Posted on 06 Jun 2024

Deep brain stimulation with electrical impulses is an FDA-approved method for treating Parkinson’s disease symptoms. More...

This technique involves using millimeter-thick electrodes to stimulate dopamine-producing cells in the substantia nigra region of the brain. However, these devices can corrode over time, and the buildup of scar tissue around the implant can disrupt the electrical signals. Researchers have now developed an alternative method that uses ultrasound instead of electricity for deep brain stimulation, delivered through a fiber about the thickness of a human hair. In a study conducted on mice, this method demonstrated that ultrasound stimulation can prompt neurons to release dopamine in a brain region commonly targeted in Parkinson’s patients.

Researchers at the Massachusetts Institute of Technology (MIT, Boston, MA, USA) who developed this technique had previously created wearable ultrasound devices for drug delivery through the skin and diagnostic imaging of various organs. However, existing methods for delivering ultrasound to the brain through the skull lack the precision to reach deep brain regions due to interference from the skull. To address this, the researchers designed a hair-thin fiber made from a flexible polymer. The fiber's tip contains a drum-like ultrasound transducer with a vibrating membrane. When this membrane, which houses a thin piezoelectric film, is driven by a small electrical voltage, it generates ultrasonic waves detectable by nearby cells. All device components are biocompatible, including the piezoelectric layer made of a novel ceramic called potassium sodium niobate (KNN). In tests on mice, the researchers showed that this ultrasound device, named ImPULS (Implantable Piezoelectric Ultrasound Stimulator), can activate neurons in the hippocampus. They then implanted the fibers into the dopamine-producing substantia nigra and demonstrated that they could stimulate neurons in the dorsal striatum to produce dopamine.

The current version of the implant is powered by an external power source, but future versions may be powered by a small implantable battery and electronics unit. The researchers have developed a microfabrication process that allows them to easily adjust the fiber's length and thickness and the frequency of the sound waves produced by the piezoelectric transducer. This customization could enable the devices to target different brain regions. The researchers now plan to explore how ultrasound stimulation affects various brain regions and whether the devices can remain functional for year-long periods. They are also considering adding a microfluidic channel to the device, which would allow it to deliver drugs along with ultrasound. In addition to its potential as a therapeutic tool for Parkinson’s or other diseases, this type of ultrasound device could be valuable for brain research, according to the researchers.

“By using ultrasonography, we can create a new way of stimulating neurons to fire in the deep brain,” says Canan Dagdeviren, an associate professor in the MIT Media Lab and the senior author of the new study published in Nature Communcations. “This device is thinner than a hair fiber, so there will be negligible tissue damage, and it is easy for us to navigate this device in the deep brain.”

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60 (127.79235839844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

61 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

62 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

63 (159.97886657715): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (!!!!! 3849.983215332): SELECT fid FROM jos_deeppockets WHERE id=294801435 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294801435 AND published='1' LIMIT 1

65 (526.18980407715): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

66 (55.074691772461): select jos_twitters.link from jos_twitters where cat=10

67 (33.140182495117): select jos_facebook.link from jos_facebook where cat=10

68 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

69 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

70 (35.04753112793): SELECT fid FROM jos_deeppockets WHERE id=294801435 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294801435 AND published='1' LIMIT 1

71 (32.901763916016): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

72 (386.95335388184): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801435 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (286.10229492188): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801435 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (64.849853515625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801435 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (33.855438232422): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801435 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (44.822692871094): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (96.08268737793): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (54.836273193359): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (310.18257141113): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (58.174133300781): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (121.8318939209): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1129.150390625): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

107 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

108 (80.108642578125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801435 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (707.86476135254): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801435 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (!!!!! 1208.0669403076): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

111 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

112 (138.99803161621): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801435 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (913.85841369629): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801435 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (885.009765625): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (658.03527832031): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (169.99244689941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

117 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

118 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

119 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

120 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

121 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

122 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

123 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

124 (287.05596923828): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 62237.024307251): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (715.97099304199): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801435 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801435 AND type='deeppockets_item' AND published='1' LIMIT 1

127 (!!!!! 19107.103347778): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (!!!!! 2823.8296508789): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (103.95050048828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (72.956085205078): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (453.94897460938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (83.92333984375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (103.95050048828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (629.18663024902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (450.13427734375): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (190.97328186035): SELECT name FROM jos_deeppockets WHERE id=214

140 (215.05355834961): SELECT name FROM jos_deeppockets WHERE id=214

141 (845.90911865234): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (752.92587280273): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

144 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

145 (!!!!! 25642.871856689): TRUNCATE TABLE jos_trademed_module

146 (929.11720275879): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801435 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (289.2017364502): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801435 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (956.05850219727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (352.85949707031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (437.97492980957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

151 (228.8818359375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

152 (!!!!! 2704.1435241699): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (478.98292541504): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

154 (423.19297790527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

155 (216.00723266602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801435 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801435 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (231.02760314941): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

157 (49.829483032227): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

158 (233.88862609863): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (414.84832763672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

160 (279.90341186523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801435 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801435 AND published='1' LIMIT 1

161 (368.11828613281): select jos_twitters.link from jos_twitters where cat=10

162 (190.97328186035): select jos_facebook.link from jos_facebook where cat=10

163 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

164 (226.02081298828): select jos_linkedin.link from jos_linkedin where cat=10

165 (586.03286743164): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

166 (!!!!! 1400.9475708008): insert into jos_banners_delta values (14202,'2025-08-02 18:44:14','216.73.216.210','view'),(14203,'2025-08-02 18:44:14','216.73.216.210','view')

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