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New Genetic Testing Procedure Combined With Ultrasound Detects High Cardiovascular Risk

By MedImaging International staff writers
Posted on 01 May 2024

A key interest area in cardiovascular research today is the impact of clonal hematopoiesis on cardiovascular diseases. More...

Clonal hematopoiesis results from mutations in hematopoietic stem cells and may lead to blood cancers. Interestingly, it is also present in individuals with normal blood counts, where it is linked with a heightened risk of severe atherosclerotic cardiovascular disease. Studies have shown that clonal hematopoiesis becomes more common with age, being detectable in up to 15% of individuals over 70. While it can progress to malignant blood diseases, its significant impact is the reduction in life expectancy due to an increased risk of atherosclerotic cardiovascular disease, which at its advanced stage, can cause heart attacks and strokes due to arterial blockages.

Now, a research team at the Medical University of Vienna (Vienna, Austria) has designed a genetic testing method for detecting clonal hematopoiesis. Combined with an ultrasound examination of the carotid artery, this testing approach can identify individuals at high risk for cardiovascular disease. For their research, the team focused on the impact of clonal hematopoiesis on patients with asymptomatic, verified carotid stenosis—a narrowing of the carotid artery due to atherosclerosis. They developed a novel assay employing high-throughput DNA sequencing for targeted genetic testing to detect mutations that cause clonal hematopoiesis. This testing method was applied to around 1,000 blood samples from the ICARAS study (Inflammation and Carotid Artery-Risk for Atherosclerosis Study).

The study revealed a significant increase in mortality among patients who have both carotid stenosis and clonal hematopoiesis. The joint detection of clonal hematopoiesis and carotid atherosclerosis led to the identification of a new combined biomarker that enhances the personalization of cardiovascular risk profiles. This allows for the early identification of high-risk patients, which in turn facilitates the timely adjustment of treatment plans and the prevention of the progression of atherosclerotic diseases, thereby reducing the incidence of strokes and heart attacks.

By utilizing ultrasound-based duplex sonography along with this innovative genetic testing, elevated cardiovascular risk can now be detected well before any symptoms of the disease appear. According to the researchers, “the results of this study provide the basis for future studies to investigate the role of clonal haematopoiesis in cardiovascular diseases", with the goal of implementing such genetic diagnostics in laboratory medicine.

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58 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (598.19221496582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

60 (!!!!! 1543.9987182617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

61 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

62 (171.89979553223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

63 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

64 (116.82510375977): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (585.07919311523): SELECT fid FROM jos_deeppockets WHERE id=294801035 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294801035 AND published='1' LIMIT 1

66 (74.148178100586): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

67 (57.93571472168): select jos_twitters.link from jos_twitters where cat=10

68 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

69 (82.015991210938): select jos_google_plus.link from jos_google_plus where cat=10

70 (33.855438232422): select jos_linkedin.link from jos_linkedin where cat=10

71 (34.809112548828): SELECT fid FROM jos_deeppockets WHERE id=294801035 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294801035 AND published='1' LIMIT 1

72 (36.001205444336): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

73 (457.0484161377): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (463.00888061523): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (66.041946411133): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (93.936920166016): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (133.03756713867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (49.829483032227): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (54.121017456055): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (78.916549682617): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

108 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

109 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (64.849853515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

112 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

113 (543.11752319336): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (613.92784118652): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (93.936920166016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801033 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (530.00450134277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801033 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (687.83760070801): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (515.93780517578): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (157.83309936523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

120 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

121 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

122 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

123 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

124 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

125 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

126 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

127 (389.81437683105): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

128 (!!!!! 23766.040802002): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

129 (679.01611328125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801035 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801035 AND type='deeppockets_item' AND published='1' LIMIT 1

130 (!!!!! 9434.9384307861): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (97.036361694336): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

132 (262.97569274902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (54.121017456055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

134 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

136 (388.86070251465): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

138 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

140 (623.94142150879): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (473.0224609375): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=214

143 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=214

144 (699.99694824219): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (581.97975158691): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

146 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

147 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

148 (!!!!! 9599.2088317871): TRUNCATE TABLE jos_trademed_module

149 (152.1110534668): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (116.82510375977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

151 (460.14785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

153 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

154 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

155 (!!!!! 1708.0307006836): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

156 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

157 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

158 (118.97087097168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801035 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801035 AND type='deeppockets_item' AND published='1' LIMIT 1

159 (56.982040405273): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (52.928924560547): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

161 (87.02278137207): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

162 (190.01960754395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

163 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801035 AND published='1' LIMIT 1

164 (72.002410888672): select jos_twitters.link from jos_twitters where cat=10

165 (50.067901611328): select jos_facebook.link from jos_facebook where cat=10

166 (45.061111450195): select jos_google_plus.link from jos_google_plus where cat=10

167 (42.200088500977): select jos_linkedin.link from jos_linkedin where cat=10

168 (392.91381835938): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

169 (!!!!! 1344.2039489746): insert into jos_banners_delta values (14202,'2025-08-02 18:40:58','216.73.216.210','view'),(14203,'2025-08-02 18:40:58','216.73.216.210','view')

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