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Focused Ultrasound Can Be Used To Deliver Drugs to Surgically Inaccessible Brain Lesions

By MedImaging International staff writers
Posted on 25 Jan 2024

Image: A USD 3.1 million grant is backing a promising focused ultrasound research (Photo courtesy of 123RF)

Cerebral cavernous malformations (CCMs), commonly known as cavernomas, are clusters of abnormally grown capillaries in the brain or spinal cord. These growths can lead to serious health issues including seizures, severe headaches, paralysis, and potentially fatal bleeding in the brain. Surgical removal is often the primary treatment for symptomatic cavernomas. A team of researchers is now developing an innovative method for drug delivery to these lesions, employing a combination of focused ultrasound and microbubbles. This technique aims to penetrate the brain’s protective blood-brain barrier, which usually prevents drugs from reaching the malformations.

CCMs are estimated to exist in one out of every 500 individuals. While many of these lesions remain asymptomatic, they can cause significant health problems for some, with symptoms escalating as the blood vessels grow. Surgical removal of these malformations can be hazardous, and medication often fails to reach the target due to the blood-brain barrier. This barrier is crucial for protecting the brain from harmful substances, but it also restricts access to many therapeutic treatments, particularly larger biologic drugs. The research team at UVA Health (Charlottesville, VA, USA) is focusing on temporarily disrupting this barrier in a highly targeted manner. Their method involves the use of microbubbles combined with focused ultrasound waves to momentarily open the blood-brain barrier at specific locations. This temporary opening permits drug penetration to areas that are typically inaccessible.

Impressively, their experiments in a genetically accurate mouse model of the disease revealed that the combination of sound waves and microbubbles alone could stabilize CCMs, even without additional medication. This discovery implies potential additional benefits of this method, extending beyond just facilitating drug delivery. Currently, the researchers are perfecting an image-guided system that allows doctors to observe the opening of the blood-brain barrier in real-time, ensuring precise drug delivery. Their next steps involve understanding how to best use these drugs to control and possibly reduce the size of the cavernomas. Their ultimate goal is to manage the growth of these lesions non-invasively, eliminating the need for invasive skull surgery. If successful, this could revolutionize the treatment and management of CCMs.

“Many CCM patients are in desperate need of more effective treatment options. Some patients have surgically inaccessible lesions that can only be treated with radiation, but such treatments can have strong side effects and take a long time to show efficacy,” said Richard J. Price, Ph.D., who is leading the research team. “We ultimately wish to treat these lesions non-invasively with biologic drugs and gene therapies, but these therapies are relatively large in size and do not penetrate well into brain tissue. Low-intensity focused ultrasound can be steered almost anywhere in the brain. It gives us a unique opportunity to precisely deliver such advanced therapies right to the CCM.”

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59 (!!!!! 9249.9256134033): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

60 (281.09550476074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

61 (!!!!! 11717.081069946): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 1812.9348754883): SELECT fid FROM jos_deeppockets WHERE id=294800011 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294800011 AND published='1' LIMIT 1

63 (!!!!! 1557.1117401123): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (!!!!! 1960.0391387939): select jos_twitters.link from jos_twitters where cat=10

65 (258.9225769043): select jos_facebook.link from jos_facebook where cat=10

66 (359.05838012695): select jos_google_plus.link from jos_google_plus where cat=10

67 (342.13066101074): select jos_linkedin.link from jos_linkedin where cat=10

68 (694.99015808105): SELECT fid FROM jos_deeppockets WHERE id=294800011 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294800011 AND published='1' LIMIT 1

69 (891.92390441895): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (!!!!! 2753.0193328857): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800011 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (514.03045654297): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800011 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1188.9934539795): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (772.95303344727): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (!!!!! 1998.9013671875): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (708.81843566895): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (74.148178100586): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (338.07754516602): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 1138.2102966309): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800011 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (!!!!! 2359.8670959473): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800011 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (91.075897216797): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 6567.9550170898): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (539.77966308594): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (324.01084899902): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (74.863433837891): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 2743.9594268799): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (574.11193847656): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (83.92333984375): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (176.90658569336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (471.11511230469): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (337.12387084961): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 2544.8799133301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

105 (110.14938354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

106 (!!!!! 8446.9318389893): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800011 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (164.03198242188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800011 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 2205.8486938477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

109 (672.1019744873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

110 (!!!!! 3893.1369781494): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800011 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 6853.1036376953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294800011 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 4127.025604248): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (764.84680175781): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1901.8650054932): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

115 (!!!!! 2876.9969940186): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

116 (!!!!! 2408.0276489258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

117 (245.80955505371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

118 (!!!!! 1628.8757324219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

119 (598.19221496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

120 (!!!!! 1976.9668579102): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

121 (!!!!! 1302.0038604736): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

122 (391.00646972656): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 66039.085388184): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1849.889755249): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800011 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800011 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 24708.986282349): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (82.015991210938): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (875.94985961914): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (470.87669372559): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 1661.7774963379): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (380.03921508789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (!!!!! 1904.0107727051): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (69.141387939453): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (!!!!! 1879.9304962158): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (70.810317993164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 2782.8216552734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (724.07722473145): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (97.036361694336): SELECT name FROM jos_deeppockets WHERE id=214

138 (51.975250244141): SELECT name FROM jos_deeppockets WHERE id=214

139 (!!!!! 5665.0638580322): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1299.1428375244): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 2525.0911712646): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

142 (162.12463378906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

143 (!!!!! 20755.052566528): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 6822.8244781494): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800011 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 1419.0673828125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294800011 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 5572.0806121826): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (456.80999755859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 2932.071685791): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

149 (730.99136352539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

150 (!!!!! 5752.0866394043): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 2118.1106567383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

152 (373.84033203125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

153 (865.93627929688): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294800011 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294800011 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (328.06396484375): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (!!!!! 1176.118850708): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (!!!!! 2405.8818817139): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 4631.9961547852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

158 (260.82992553711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294800011 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294800011 AND published='1' LIMIT 1

159 (319.00405883789): select jos_twitters.link from jos_twitters where cat=10

160 (136.8522644043): select jos_facebook.link from jos_facebook where cat=10

161 (428.91502380371): select jos_google_plus.link from jos_google_plus where cat=10

162 (69.141387939453): select jos_linkedin.link from jos_linkedin where cat=10

163 (!!!!! 1210.9279632568): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

164 (!!!!! 1262.903213501): insert into jos_banners_delta values (14202,'2025-08-03 06:54:05','216.73.216.210','view'),(14203,'2025-08-03 06:54:05','216.73.216.210','view')

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