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World’s First Brain Stimulation Treatment for Neurological Diseases Uses Ultrasound Technology

By MedImaging International staff writers
Posted on 19 Dec 2023

Image: Annotated illustration of brain tissue and proposed project technology (Photo courtesy of The University of Melbourne)

The effectiveness of drug treatments for individuals with neurological diseases like Parkinson's disease and epilepsy often diminishes over time, necessitating alternative therapeutic approaches. Movement symptoms in such conditions are typically the result of disorganized neural signals in the brain areas governing movement. Deep brain stimulation, a technique that disrupts these erratic signals, has shown promise in managing tremors and other movement-related symptoms. It also holds the potential for controlling, and possibly even preventing, seizures in epilepsy patients. Now, researchers are exploring a groundbreaking brain stimulation treatment that employs ultrasound, delivered through a device located inside a brain blood vessel, to address symptoms of neurological disorders.

A group of biomedical engineers at The University of Melbourne (Victoria, Australia), along with their colleagues, are developing ‘endovascular focused ultrasound’ technology, which could substantially enhance the lives of those with neurological diseases. Currently, electrical brain stimulation is a treatment option, but it requires invasive brain surgery to implant electrodes and often lacks precision in stimulating the correct brain regions. The accuracy of electrode placement is crucial; slight misplacements can lead to diminished efficacy and unintended side effects. The team's endovascular-focused ultrasound technology, anticipated to be available in over a decade, presents a safer alternative to existing treatments, avoiding the need for open brain surgery and utilizing ultrasound instead of electrical stimulation.

This innovative method involves inserting an array of tiny transducers permanently into a brain blood vessel, likely through the jugular vein, akin to current stent insertion practices in the heart and brain. These transducers would be connected to a chest-implanted device similar to a pacemaker, which would power and control the ultrasound stimulation. Thanks to advancements in nanofabrication technology, which is also used in computer chip manufacturing, researchers can produce extraordinarily small ultrasound transducers. These transducers are fine enough to fit inside a blood vessel, being narrower than human hair. When arranged in an array, they can precisely focus the ultrasound beam on a specific brain target, minimizing stimulation to surrounding tissue. The team aims for a successful initial demonstration of this novel brain stimulation method within a three-year project timeline and is hopeful that the first human trials could commence by 2030.

“We have demonstrated preliminary safety and efficacy of implanting neurotechnology within cortical blood vessels to enable people with paralysis to control external equipment with their minds,” said Professor Nicholas Opie from the University of Melbourne Department of Medicine. “Ultrasound is a new method of stimulating the brain and has the potential to provide transformative treatments for people with neurological disorders such as Parkinson’s, epilepsy and depression.”

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61 (!!!!! 4348.0396270752): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (488.0428314209): SELECT fid FROM jos_deeppockets WHERE id=294799646 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799646 AND published='1' LIMIT 1

63 (46.014785766602): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (121.8318939209): select jos_twitters.link from jos_twitters where cat=10

65 (89.883804321289): select jos_facebook.link from jos_facebook where cat=10

66 (133.03756713867): select jos_google_plus.link from jos_google_plus where cat=10

67 (83.92333984375): select jos_linkedin.link from jos_linkedin where cat=10

68 (735.04447937012): SELECT fid FROM jos_deeppockets WHERE id=294799646 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294799646 AND published='1' LIMIT 1

69 (41.961669921875): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (308.99047851562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (303.98368835449): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (87.02278137207): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (103.95050048828): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (107.0499420166): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (32.901763916016): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (102.99682617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (70.095062255859): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 3157.1388244629): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (110.14938354492): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1724.0047454834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

105 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

106 (!!!!! 4245.0428009033): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 1015.9015655518): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 3293.0374145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

109 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

110 (75.101852416992): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (721.93145751953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (841.85600280762): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (622.98774719238): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

115 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

116 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

117 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

118 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

119 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

120 (75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

121 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

122 (468.01567077637): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 63534.021377563): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 3659.0099334717): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799646 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799646 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 23879.051208496): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (84.877014160156): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (62.942504882812): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (70.095062255859): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (458.95576477051): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (54.121017456055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 3681.8981170654): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (719.07043457031): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 3123.9986419678): SELECT name FROM jos_deeppockets WHERE id=214

138 (163.07830810547): SELECT name FROM jos_deeppockets WHERE id=214

139 (771.04568481445): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (604.15267944336): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (522.85194396973): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

142 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

143 (!!!!! 18943.071365356): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 6400.1083374023): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (390.05279541016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799646 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1157.0453643799): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (278.94973754883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (617.98095703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

149 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

150 (!!!!! 2418.041229248): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 3760.0994110107): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

152 (186.92016601562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

153 (351.1905670166): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799646 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799646 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (401.02005004883): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (51.975250244141): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (40.054321289062): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (897.88436889648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

158 (105.14259338379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799646 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799646 AND published='1' LIMIT 1

159 (!!!!! 2670.0496673584): select jos_twitters.link from jos_twitters where cat=10

160 (82.015991210938): select jos_facebook.link from jos_facebook where cat=10

161 (190.97328186035): select jos_google_plus.link from jos_google_plus where cat=10

162 (33.855438232422): select jos_linkedin.link from jos_linkedin where cat=10

163 (!!!!! 1152.9922485352): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

164 (!!!!! 1260.0421905518): insert into jos_banners_delta values (14202,'2025-08-03 06:56:54','216.73.216.210','view'),(14203,'2025-08-03 06:56:54','216.73.216.210','view')

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