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Novel Ultrasound Imaging Technique Could Reveal Immune Cell Secrets and Improve Treatments

By MedImaging International staff writers
Posted on 13 Dec 2023
Image: Nano-sized bubbles allow macrophages to stand out from their fellow cells in ultrasound imagery (Photo courtesy of Penn State)
Image: Nano-sized bubbles allow macrophages to stand out from their fellow cells in ultrasound imagery (Photo courtesy of Penn State)

Macrophages are small, essential cells that play a crucial role in the immune system, involved in various functions such as pathogen detection, wound healing, and managing inflammation related to injuries and diseases like diabetes and rheumatoid arthritis. They have potential applications in cell-based therapies for conditions including cancer, autoimmune disorders, infections, and tissue damage. These therapies might entail isolating, modifying, or engineering macrophages to augment their disease-fighting, immune-regulating, and tissue-repairing abilities. However, the effectiveness of macrophage therapies hinges on the ability to monitor these cells within the body. Researchers have now developed an innovative ultrasound imaging method to continuously observe macrophages in mammalian tissue, with future prospects for human use.

Due to their invisibility in traditional ultrasound imaging, researchers at Penn State (University Park, PA, USA) formulated a contrast agent to distinguish macrophages from other cells in the tissue. This involved the use of nanoemulsions - mixtures of minuscule oil droplets, nanometers in size, suspended in a liquid. The team aimed to create more stable bubbles using these nanoemulsions. In ultrasound imaging, gas bubbles effectively reflect sound waves, but standard bubbles injected into the body burst quickly. The researchers introduced nanoemulsion droplets to the macrophages, which internalized them. Upon ultrasound exposure, the droplets underwent a phase change to gas, forming bubbles. This transformation was facilitated by the ultrasound waves' pressure, which oscillates to force the droplet to vaporize into a gas bubble.

This technique was successfully tested in a porcine tissue sample, demonstrating the ability to image macrophages effectively. This method offers a continuous insight into the actions of immune cells within the body, enhancing the understanding of immune system regulation and its role in combating diseases. Moreover, it holds promise for advancing immune cell therapies, potentially leading to more effective treatments with fewer side effects. For instance, it could enable the development of targeted macrophage cell therapies for cancer patients. Future research directions include applying this technique for visualizing other types of immune cells in humans or monitoring arterial plaque buildup.

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92 (957.01217651367): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (334.02442932129): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (148.77319335938): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (257.96890258789): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (387.19177246094): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (226.97448730469): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (212.9077911377): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 7483.0055236816): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
105 (275.85029602051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
106 (!!!!! 6807.804107666): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799578 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (!!!!! 1654.1481018066): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799578 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (!!!!! 8540.8687591553): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
109 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
110 (238.89541625977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799578 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (970.12519836426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294799578 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (733.85238647461): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (!!!!! 2290.0104522705): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (302.79159545898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
115 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
116 (488.0428314209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
117 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
118 (349.99847412109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
119 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
120 (272.03559875488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
121 (187.15858459473): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
122 (406.02684020996): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 63534.97505188): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (!!!!! 1218.0805206299): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799578 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799578 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (58.889389038086): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (267.02880859375): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (500.91743469238): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (174.99923706055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (900.0301361084): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (519.99092102051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (386.95335388184): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (47.922134399414): SELECT name FROM jos_deeppockets WHERE id=214
138 (36.954879760742): SELECT name FROM jos_deeppockets WHERE id=214
139 (728.13034057617): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (612.97416687012): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (!!!!! 4293.9186096191): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
142 (!!!!! 2968.0728912354): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
143 (!!!!! 18487.930297852): TRUNCATE TABLE jos_trademed_module
144 (!!!!! 14520.168304443): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799578 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (146.15058898926): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294799578 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (566.95938110352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
149 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
150 (!!!!! 1535.8924865723): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (!!!!! 5460.0238800049): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
152 (!!!!! 9654.0451049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
153 (!!!!! 11719.942092896): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799578 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799578 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (!!!!! 7979.8698425293): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
155 (!!!!! 7926.9409179688): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
156 (!!!!! 7745.0275421143): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (!!!!! 7910.0131988525): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
158 (!!!!! 7972.0020294189): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799578 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799578 AND published='1' LIMIT 1
159 (!!!!! 7665.8725738525): select jos_twitters.link from jos_twitters where cat=10
160 (!!!!! 9562.9692077637): select jos_facebook.link from jos_facebook where cat=10
161 (!!!!! 6702.8999328613): select jos_google_plus.link from jos_google_plus where cat=10
162 (!!!!! 4104.8526763916): select jos_linkedin.link from jos_linkedin where cat=10
163 (!!!!! 5168.9147949219): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)
164 (!!!!! 10139.942169189): insert into jos_banners_delta values (14202,'2025-08-03 07:02:50','216.73.216.210','view'),(14203,'2025-08-03 07:02:50','216.73.216.210','view')