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Anatomically Precise Ultrasound-Based Technique to Enable Noninvasive Biopsies for Brain Tumors

By MedImaging International staff writers
Posted on 28 Sep 2023

The blood-brain barrier serves as a protective wall, keeping the brain safe from harmful elements like viruses and toxins in the blood. More...

This makes it challenging for doctors to obtain molecular and genetic information, which could be critical for diagnosing and treating brain conditions like cancer. Typically, neurosurgeons have to perform risky surgical biopsies to gather this data, which is not an option for every type of brain disease or tumor. Now, researchers have developed a method called sonobiopsy, which uses ultrasound technology and microbubbles to temporarily disrupt this barrier, allowing vital molecules like RNA, DNA, and proteins to move into the bloodstream where they can be detected and studied.

Researchers at Washington University in St. Louis (WUSTL, St. Louis, MO, USA) who had developed and previously tested the technique in animals have now demonstrated the technique to be feasible and safe for use in humans, paving the way for noninvasive biopsies for suspected brain tumors and other brain diseases. The researchers had to rely on an expensive ultrasound setup that had to be integrated with an MRI scanner, limiting its usage to specific locations. To make the procedure more accessible, the team designed a portable handheld ultrasound probe which was attached to a stereotactic pointer that is commonly used by neurosurgeons for identifying brain lesions. This new device could be seamlessly incorporated into existing medical procedures without the need for extra training for the neurosurgeons involved.

The sonobiopsy technique involves focusing ultrasound on a particular brain lesion with millimeter-scale accuracy, followed by injecting microbubbles into the bloodstream. These microbubbles reach the targeted area and burst, creating small, temporary openings in the blood-brain barrier. These openings seal themselves within a few hours, causing no lasting harm. This brief window allows biomolecules from the lesion to escape into the blood, making it possible to collect them through a standard blood test. The researchers applied this method to five individuals with brain tumors, later surgically removing the tumors as per standard medical protocols. Blood analysis conducted before and after the sonobiopsy showed a significant increase in circulating tumor DNA levels—anywhere from 1.6 to 5.6 times, based on the specific type of DNA being analyzed. This DNA offers critical insights into the genetic makeup of the tumor, influencing how aggressively it should be treated. Additionally, there was no evidence of brain tissue damage, affirming the safety of the procedure.

“Magnetic resonance imaging (MRI) revolutionized the field of brain disease diagnosis in the 1980s and ‘90s by allowing for structural and functional imaging of the brain,” said Eric C. Leuthardt, MD, co-inventor of the technology. “Sonobiopsy is the third revolution, the molecular revolution. With this technique, we can obtain a blood sample that reflects the gene expression and the molecular features at the site of a lesion in the brain. It’s like doing a brain biopsy without the dangers of brain surgery.”

“We’ve essentially initiated a new field of study for brain conditions,” added Hong Chen, the co-inventor of the technology. “With this capability to noninvasively, nondestructively access every part of the brain, we can get genetic information on tumors before going in surgically, which would help a neurosurgeon determine how best to approach the surgery. If they see something suspicious on imaging, they could confirm whether a tumor is recurring or not. We can now start to interrogate diseases for which surgical biopsies aren’t done, such as neurodevelopmental, neurodegenerative and psychiatric disorders.”

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56 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (472.06878662109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (!!!!! 2588.9873504639): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

59 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

60 (!!!!! 1224.9946594238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

61 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

62 (874.04251098633): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

63 (378.13186645508): SELECT fid FROM jos_deeppockets WHERE id=294798765 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294798765 AND published='1' LIMIT 1

64 (469.92301940918): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

65 (281.09550476074): select jos_twitters.link from jos_twitters where cat=10

66 (67.234039306641): select jos_facebook.link from jos_facebook where cat=10

67 (49.114227294922): select jos_google_plus.link from jos_google_plus where cat=10

68 (430.10711669922): select jos_linkedin.link from jos_linkedin where cat=10

69 (255.10787963867): SELECT fid FROM jos_deeppockets WHERE id=294798765 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294798765 AND published='1' LIMIT 1

70 (66.041946411133): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

71 (187.87384033203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (430.10711669922): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (194.07272338867): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 1302.95753479): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (!!!!! 1585.9603881836): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (58.174133300781): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (46.968460083008): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.226043701172): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

106 (78.201293945312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

107 (129.93812561035): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (73.19450378418): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (308.03680419922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

110 (153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

111 (110.86463928223): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (540.97175598145): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (655.8895111084): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (452.04162597656): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

116 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

117 (195.02639770508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

118 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

119 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

120 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

121 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

122 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

123 (339.98489379883): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 50452.947616577): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (581.97975158691): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798765 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798765 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 15612.840652466): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (107.0499420166): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (59.127807617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (319.9577331543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (468.01567077637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (391.00646972656): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (152.1110534668): SELECT name FROM jos_deeppockets WHERE id=214

139 (33.140182495117): SELECT name FROM jos_deeppockets WHERE id=214

140 (527.85873413086): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (513.07678222656): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

143 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

144 (!!!!! 5371.09375): TRUNCATE TABLE jos_trademed_module

145 (!!!!! 9694.8146820068): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1576.1852264404): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798765 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (880.00297546387): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (339.98489379883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

150 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

151 (!!!!! 1608.13331604): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

153 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

154 (477.07557678223): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798765 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798765 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (673.05564880371): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (!!!!! 5066.8716430664): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

157 (229.1202545166): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (!!!!! 1317.024230957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

159 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798765 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798765 AND published='1' LIMIT 1

160 (!!!!! 2507.9250335693): select jos_twitters.link from jos_twitters where cat=10

161 (96.08268737793): select jos_facebook.link from jos_facebook where cat=10

162 (!!!!! 1949.0718841553): select jos_google_plus.link from jos_google_plus where cat=10

163 (!!!!! 2121.2100982666): select jos_linkedin.link from jos_linkedin where cat=10

164 (940.08445739746): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

165 (!!!!! 5171.7758178711): insert into jos_banners_delta values (14202,'2025-08-03 22:54:20','216.73.216.210','view'),(14203,'2025-08-03 22:54:20','216.73.216.210','view')

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