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Diagnostic Technique Assesses Structural Changes in Cardiac Arrhythmia to Enable Personalized Treatment

By MedImaging International staff writers
Posted on 07 Aug 2023

Atrial fibrillation, one of the most common types of cardiac arrhythmia, is characterized by irregular and rapid heartbeats that can lead to the formation of blood clots in the heart. This increases the risk of stroke, heart failure, and other related complications. Currently, atrial fibrillation is classified based on the duration of the arrhythmia, but this temporal classification does not provide information about the extent of structural and electrophysiological changes, known as atrial remodeling, that occur in the hearts of patients with atrial fibrillation. Atrial remodeling is a crucial parameter, especially in the initial months of the condition, as the underlying disease processes can progress at different rates. Now, a new diagnostic method allows for the simultaneous assessment of both electrical and mechanical (contractile) activity in the heart atria during atrial fibrillation, enabling timely intervention and better management of the condition.

Over the past 10 years, a team of national and international experts led by scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC, Madrid, Spain) has been collaborating to integrate electrical and mechanical cardiac data in order to enable personalized characterization of the pathological changes associated with the progression of atrial fibrillation. The researchers were successful in achieving this through a multidisciplinary approach. Engineers and physicists worked together in the initial phase to devise the most suitable strategy for integrating the electrical and mechanical data. They found a solution to measure mechanical activity by using Doppler imaging, which offers a noninvasive method of providing information on atrial tissue movements, and to measure electrical activity by utilizing surface electrocardiography.

Both approaches are easy to implement in a clinical setting since they are noninvasive and can be performed during a transthoracic ultrasound examination, a routine study of the heart's shape and function along with some internal structures. The second phase involved experts in biology, biotechnology, biochemistry, and biomedical engineering working in collaboration with the CNIC Proteomics Unit and clinical cardiologists. Experimental studies in this phase correlated the information obtained through the new approach with underlying pathological changes in atrial tissue. This led to the development of advanced mapping techniques and computer simulations that shed light on the mechanisms underlying electrical and mechanical remodeling during the progression of atrial fibrillation.

In the final phase, a multicenter prospective study involving 83 patients in the early stages of atrial fibrillation was conducted to determine the prognostic value of simultaneously assessing electrical and mechanical activity in the atria of these patients. The experimental and clinical findings revealed an imbalance between electrical and mechanical activation in the atria during the early stages of the disease. This causes dissociation between the two parameters, termed "atrial electromechanical dissociation," where the contractile activation cannot keep up with the electrical activation. This phenomenon is specific to each individual patient and is usually observed within the first 2-3 months after an uninterrupted atrial fibrillation episode. A key advantage of this new approach is that it identifies atrial electromechanical dissociation before overt clinical signs of structural atrial remodeling appear. This early detection could be crucial for timely intervention and better management of the condition.

“The use of this new diagnostic approach allows early characterization of the underlying remodeling in patients with atrial fibrillation,” said study leader David Filgueiras. “The study shows that it is possible to integrate electrical and mechanical data from the atria of patients with atrial fibrillation to obtain personalized prognostic information about the clinical progression of the disease.”

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58 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798190 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 12273.073196411): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798190 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

60 (!!!!! 2523.1838226318): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

61 (!!!!! 16707.897186279): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

62 (!!!!! 1153.9459228516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

63 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

64 (272.03559875488): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (!!!!! 2797.1267700195): SELECT fid FROM jos_deeppockets WHERE id=294798190 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294798190 AND published='1' LIMIT 1

66 (!!!!! 2000.093460083): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

67 (238.89541625977): select jos_twitters.link from jos_twitters where cat=10

68 (!!!!! 1513.0043029785): select jos_facebook.link from jos_facebook where cat=10

69 (!!!!! 1345.157623291): select jos_google_plus.link from jos_google_plus where cat=10

70 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

71 (36.954879760742): SELECT fid FROM jos_deeppockets WHERE id=294798190 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294798190 AND published='1' LIMIT 1

72 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

73 (!!!!! 4157.0663452148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798190 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (271.08192443848): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798190 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (!!!!! 2553.9398193359): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (957.01217651367): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (159.02519226074): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (169.99244689941): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 3487.1101379395): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (!!!!! 2806.9019317627): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (232.93495178223): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (569.10514831543): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (42.915344238281): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798190 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (26.941299438477): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798190 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (32.186508178711): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (!!!!! 1842.9756164551): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.226043701172): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

108 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

109 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798190 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (41.007995605469): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798190 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (226.02081298828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

112 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

113 (396.0132598877): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798190 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (!!!!! 2349.853515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798190 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798185 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (428.91502380371): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294798185 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (!!!!! 7830.8582305908): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (!!!!! 7936.954498291): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (!!!!! 7698.0590820312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

120 (!!!!! 8072.8530883789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

121 (!!!!! 7935.0471496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

122 (!!!!! 7739.0670776367): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

123 (!!!!! 7744.7891235352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

124 (!!!!! 7672.0714569092): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

125 (!!!!! 7879.0187835693): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 47584.056854248): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (233.88862609863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

128 (!!!!! 3899.097442627): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

129 (!!!!! 7887.8402709961): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798190 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798190 AND type='deeppockets_item' AND published='1' LIMIT 1

130 (!!!!! 2013971.0903168): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (!!!!! 2656587.8391266): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

132 (109.91096496582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

134 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

136 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

138 (567.91305541992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (455.85632324219): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (295.87745666504): SELECT name FROM jos_deeppockets WHERE id=214

141 (62.942504882812): SELECT name FROM jos_deeppockets WHERE id=214

142 (705.95741271973): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (463.96255493164): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (!!!!! 4766.9410705566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

145 (150.91896057129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

146 (!!!!! 23422.002792358): TRUNCATE TABLE jos_trademed_module

147 (210.04676818848): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798190 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (!!!!! 1403.80859375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294798190 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (!!!!! 2259.9697113037): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

152 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

153 (!!!!! 9917.9744720459): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

155 (!!!!! 1591.9208526611): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

156 (628.94821166992): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798190 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798190 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (58.889389038086): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

158 (47.922134399414): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (56.982040405273): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (!!!!! 4401.9222259521): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

161 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798190 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798190 AND published='1' LIMIT 1

162 (205.03997802734): select jos_twitters.link from jos_twitters where cat=10

163 (61.988830566406): select jos_facebook.link from jos_facebook where cat=10

164 (92.029571533203): select jos_google_plus.link from jos_google_plus where cat=10

165 (45.061111450195): select jos_linkedin.link from jos_linkedin where cat=10

166 (!!!!! 1190.9008026123): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

167 (!!!!! 12436.866760254): insert into jos_banners_delta values (14615,'2025-04-30 02:46:52','13.59.134.12','view'),(14202,'2025-04-30 02:46:52','13.59.134.12','view'),(14203,'2025-04-30 02:46:52','13.59.134.12','view')

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