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Automated, Motorized Endoscopic Ultrasound Biopsy Device Advances Precision Medicine

By MedImaging International staff writers
Posted on 04 May 2022

Image: Precision-GI Endoscopic Biopsy Device (Photo courtesy of Limaca Medical)

Endoscopic biopsy is performed by a gastroenterologist who accesses the targeted gastrointestinal (GI) tumor utilizing an ultrasound visualization endoscope. Suspect GI tumor locations include submucosal lesions, mediastinal masses, lymph nodes, intraperitoneal masses, and within GI related organs such as the pancreas and liver. Today's endoscopic biopsy devices have limitations in consistently obtaining quality tissue with sufficient quantity, which can result in sample tissue fragmentation, inadequate tissue amount, and blood contamination. Now, a new endoscopic ultrasound biopsy device featuring a unique motorized, automated rotational cutting needle is designed to obtain biopsies for definitive diagnosis of pancreatic cancer and other life-threatening GI cancers more quickly and less traumatically than current products.

Limaca Medical’s (Yokneam, Israel) Precision-GI device is designed to obtain tumor tissue within or adjacent to the GI tract. It is deployed and operated through an instrument channel in the endoscope to biopsy the tumor. While all existing endoscopic ultrasound fine needle biopsy (EUS-FNB) devices require manual hand operation, Precision GI features a unique motorized, automated rotational cutting needle for successful tissue acquisition. The automated design provides for more efficient and effective diagnosis of GI cancers since it is designed to yield significantly superior quality and quantity of diagnostically relevant biopsy tissue.

Initial cases from Limaca's comparative feasibility clinical study, which is ongoing, demonstrates that Precision GI obtained contiguous intact core tissue samples fully adequate for definitive diagnosis of pancreatic lesions. The clean, non-contaminated tissue samples provided a high percentage of tumor content, with less blood and extraneous fluids. Limaca’s Precision-GI endoscopic ultrasound biopsy product has received a Breakthrough Device Designation from the U.S. Food and Drug Administration (FDA). Under the program, the FDA will provide Limaca with the opportunity to provide its feedback during the pre-market phase and prioritized review of the device submission.

"We are pleased with the FDA's decision to grant the Breakthrough Device Designation to Precision-GI," said Carl Rickenbaugh, Limaca's CEO. "At Limaca, our vision is to ensure that endoscopic biopsies always achieve a definitive diagnosis to enable optimal and timely GI-cancer treatment. We are dedicated to the mission to provide a far better endoscopic biopsy experience for the endoscopist and patient, with the goal to achieve a faster, more efficient biopsy yield with highly consistent results. With the Breakthrough Device Designation, we look forward to accelerating our progress toward our goal of obtaining the FDA's 510(k) clearance to bring Precision-GI to patients in the US in the near future."

"Precision-GI is an automated, motorized endoscopic biopsy product that has the potential to improve our biopsy results for the evaluation of gastrointestinal malignancies. Endoscopic biopsy is a highly specialized, high skill procedure. We welcome the innovation of Precision-GI which can provide automation and standardization of outcomes with less variation from operator to operator," said Seth A. Gross, MD, Clinical Chief, Division of Gastroenterology and Hepatology, NYU Langone Health. "Our field is driving toward patient centric individualized cancer therapy, known as Precision Medicine, which requires consistently high quality and quantity of endoscopic biopsy tissue, enabling optimal matching of the tumor's genetic profile to personalize a patient's treatment plan."

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55 (886.91711425781): SELECT name FROM jos_deeppockets WHERE id=294792760 LIMIT 1

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57 (670.19462585449): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

58 (217.91458129883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792760 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (689.02969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792760 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

60 (!!!!! 1432.1804046631): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

61 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

62 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

63 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

64 (161.88621520996): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (550.98533630371): SELECT fid FROM jos_deeppockets WHERE id=294792760 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294792760 AND published='1' LIMIT 1

66 (56.028366088867): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

67 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

68 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

69 (35.04753112793): select jos_google_plus.link from jos_google_plus where cat=10

70 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

71 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE id=294792760 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294792760 AND published='1' LIMIT 1

72 (48.160552978516): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

73 (335.9317779541): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792760 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (241.99485778809): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792760 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (58.889389038086): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (54.836273193359): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (64.13459777832): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792760 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792760 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (34.809112548828): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

108 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

109 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792760 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (48.160552978516): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792760 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

112 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

113 (442.9817199707): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792760 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (457.0484161377): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792760 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (58.174133300781): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792754 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (355.00526428223): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792754 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (644.92225646973): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (388.14544677734): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

120 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

121 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

122 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

123 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

124 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

125 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

126 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

127 (304.9373626709): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

128 (!!!!! 20123.00491333): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

129 (509.97734069824): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792760 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792760 AND type='deeppockets_item' AND published='1' LIMIT 1

130 (58.889389038086): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (36.001205444336): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

132 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

134 (64.13459777832): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

136 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

138 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

140 (514.98413085938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (330.92498779297): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (38.862228393555): SELECT name FROM jos_deeppockets WHERE id=214

143 (159.02519226074): SELECT name FROM jos_deeppockets WHERE id=214

144 (640.869140625): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (524.99771118164): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

146 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

147 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

148 (!!!!! 20611.047744751): TRUNCATE TABLE jos_trademed_module

149 (144.95849609375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792760 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (147.10426330566): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792760 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

151 (!!!!! 1376.8672943115): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

153 (322.81875610352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

154 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

155 (!!!!! 1263.8568878174): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

156 (965.11840820312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

157 (282.04917907715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

158 (46.968460083008): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792760 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792760 AND type='deeppockets_item' AND published='1' LIMIT 1

159 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

161 (66.995620727539): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

162 (!!!!! 1204.9674987793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

163 (154.97207641602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792760 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792760 AND published='1' LIMIT 1

164 (53.882598876953): select jos_twitters.link from jos_twitters where cat=10

165 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

166 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

167 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

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