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Ultrasound Non-Invasively Prevents or Reverses Onset of Diabetes in Studies

By MedImaging International staff writers
Posted on 01 Apr 2022

We could be moving closer to the day when diabetes is no longer monitored and managed with blood sugar tests, insulin injections and drug treatments A research team has demonstrated the ability to prevent or reverse the onset of diabetes by using ultrasound to non-invasively stimulate specific neurometabolic pathways in the body in three different preclinical models. More...

The findings represent a significant milestone in the field of bioelectronic medicine, which is exploring new ways to treat chronic diseases such as diabetes using electronic devices to modulate the body’s nervous system.

A research team led by General Electric (Boston, MA, USA) has been developing a novel, non-invasive stimulation technique that uses ultrasound to stimulate specific neural pathways within organs that are associated with disease. Their first studies showing initial results using ultrasound-prototype devices with diabetic models was followed by additional work at partner sites investigating the specific ion channels associated with the ultrasound effect within in vitro cultures; the direct effects of ultrasound stimulation on nerve activity using recording electrodes; testing the ultrasound treatment effect in a second and third models; and the magnitude of the effect on blood glucose using quantitative glucose clamp methods.

The latest advances show the potential of bioelectronic medicine as an alternative or companion to drugs in the treatment of chronic illnesses including Type-2 diabetes and inflammatory disorders. The findings showed that GE’s non-invasive stimulation technique using ultrasound was effective in both genetic and diet-induced models of Type- 2 diabetes. In both cases, the treatment was able to improve both glucose tolerance and insulin resistance. The team is now conducting human feasibility trials with diabetic subjects.

GE Research and its collaborators have been engaged in additional preclinical and initial clinical studies that investigate the effects of alternate dosing (i.e., type of ultrasound pulse and duration of treatment). The team is still determining is the frequency of treatments that is needed to maintain the reversal of diabetes under different stimulation parameters. In these studies, the team found that regular short treatments (i.e., three minutes every day) resulted in long-term maintenance of normal blood glucose levels.

“We have shown that ultrasound can be used to prevent or reverse diabetes in these preclinical studies. We’re now in the midst of human feasibility trials with a group of Type-2 diabetic subjects, which begins our work toward clinical translation,” said Christopher Puleo, a senior biomedical engineer at GE Research who co-led the diabetes studies. “The use of ultrasound could be a game-changer in how bioelectronic medicines are used and applied to disease, such as Type- 2 diabetes, in the future. Non-pharmaceutical and device-based methods to augment or replace the current drug-treatments may add a new therapeutic choice for physicians and patients in the future.”

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60 (180.95970153809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

61 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

62 (148.05793762207): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

63 (643.96858215332): SELECT fid FROM jos_deeppockets WHERE id=294792239 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294792239 AND published='1' LIMIT 1

64 (67.949295043945): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

65 (77.009201049805): select jos_twitters.link from jos_twitters where cat=10

66 (37.908554077148): select jos_facebook.link from jos_facebook where cat=10

67 (33.140182495117): select jos_google_plus.link from jos_google_plus where cat=10

68 (33.140182495117): select jos_linkedin.link from jos_linkedin where cat=10

69 (51.021575927734): SELECT fid FROM jos_deeppockets WHERE id=294792239 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294792239 AND published='1' LIMIT 1

70 (69.856643676758): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

71 (499.96376037598): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792239 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (395.77484130859): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792239 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (62.942504882812): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (95.129013061523): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (56.028366088867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792239 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (38.14697265625): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792239 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (85.830688476562): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

106 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

107 (68.902969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792239 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792239 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

110 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

111 (84.161758422852): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792239 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (728.84559631348): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792239 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (!!!!! 1159.9063873291): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (542.16384887695): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

116 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

117 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

118 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

119 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

120 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

121 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

122 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

123 (567.91305541992): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 23933.887481689): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (694.99015808105): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792239 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792239 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 9620.9049224854): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (134.94491577148): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (99.897384643555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (117.06352233887): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (452.04162597656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (526.90505981445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (366.9261932373): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (56.028366088867): SELECT name FROM jos_deeppockets WHERE id=214

139 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=214

140 (674.96299743652): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (554.08477783203): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

143 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

144 (!!!!! 10057.926177979): TRUNCATE TABLE jos_trademed_module

145 (129.93812561035): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792239 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792239 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (612.97416687012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (85.830688476562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

150 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

151 (!!!!! 1415.0142669678): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

153 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

154 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792239 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792239 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (38.14697265625): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

157 (72.002410888672): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (200.03318786621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

159 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792239 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792239 AND published='1' LIMIT 1

160 (72.002410888672): select jos_twitters.link from jos_twitters where cat=10

161 (35.04753112793): select jos_facebook.link from jos_facebook where cat=10

162 (35.04753112793): select jos_google_plus.link from jos_google_plus where cat=10

163 (43.153762817383): select jos_linkedin.link from jos_linkedin where cat=10

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