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Device Enables Non-Invasive and Safe Ultrasound Brain Treatments

By MedImaging International staff writers
Posted on 29 Mar 2022

Current approaches in ultrasound-based therapies for the brain are focusing ultrasound waves to reach their specific target in the brain. More...

For example, ultrasound waves are currently being used in clinical trials to treat epilepsy. But this has proven difficult, as ultrasound tends to bounce around within the skull, which leads to some areas of the brain being over-exposed while others are not exposed enough. In worst-case scenarios, this can cause hemorrhage and overheating in brain tissue. Now, a team of engineers has developed a device that is a first step to enabling noninvasive, ultrasound-based therapies for the brain.

Researchers at the UC San Diego Jacobs School of Engineering (La Jolla, CA, USA) developed the device by attempting a different approach: diffusing ultrasound waves instead of focusing them. They accomplished this by placing a microscale diffuser on the transducer that produces the ultrasound waves. The device is built based on the Schroeder diffuser–the best sound diffuser mathematical models can provide. The diffuser is built with tiny pits that modulate how the ultrasound waves are emitted. Specifically, the diffuser ensures the waves are emitted in a staggered manner, which helps prevent the creation of echoes. The depths of the pits are calculated with the Schroeder diffuser model. This is the same math that is used to design concert halls so that every audience member can hear music perfectly.

The ultrasound waves are applied to cells that have been engineered to be more responsive to ultrasound stimuli. The cells are exposed to an adenovirus that causes them to form an ion channel called TRPA1 that is sensitive to ultrasound. Researchers showed that the device worked as intended first in a Petri dish with human embryonic kidney cells and neuron cells. The cells showed twice as high an activation in the TRPA1 channel with the diffuser than without. In addition, researchers used the diffuser with an ultrasound wave generator on mice. They found that the diffuser creates a uniform acoustic field in the skull cavity, ensuring that only the brain regions engineered to be sensitive to ultrasound were stimulated. Next steps include better understanding the way ultrasound waves stimulate cells and conducting broader in vivo studies.

“We can’t modify the inside of the skull,” said senior author Professor James Friend, in the Department of Mechanical and Aerospace Engineering at the University of California San Diego. “The only thing we could do was to change how the device that produces the sound works. By using a targeted approach for this delivery, we can use uniformly distributed ultrasound instead of focused ultrasound.”

“The idea behind sonogenetics is to engineer cells to be more responsive to ultrasound stimuli,” said Aditya Vasan, a PhD student in Friend’s lab and the paper’s first author. “We do this by screening for proteins that respond to ultrasound stimulation at specific pressures and frequencies; and by genetically engineering specific brain regions to express these proteins."

“One of the goals with sonogenetics is to control which cells respond: think of it as a knob that controls lights that you have accurate control over,” added Vasan. “Ultimately, we want to show that sonogenetics work in people.”

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59 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

60 (151.8726348877): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

61 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

62 (151.8726348877): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

63 (654.93583679199): SELECT fid FROM jos_deeppockets WHERE id=294792192 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294792192 AND published='1' LIMIT 1

64 (59.843063354492): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

65 (70.095062255859): select jos_twitters.link from jos_twitters where cat=10

66 (40.054321289062): select jos_facebook.link from jos_facebook where cat=10

67 (39.100646972656): select jos_google_plus.link from jos_google_plus where cat=10

68 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10

69 (52.928924560547): SELECT fid FROM jos_deeppockets WHERE id=294792192 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294792192 AND published='1' LIMIT 1

70 (46.968460083008): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

71 (492.09594726562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792192 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (339.98489379883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792192 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (56.982040405273): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (74.148178100586): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (73.909759521484): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792192 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (39.815902709961): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792192 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

106 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

107 (74.863433837891): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792192 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792192 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (109.91096496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

110 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

111 (70.095062255859): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792192 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (921.01097106934): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792192 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (648.97537231445): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (509.02366638184): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

116 (115.87142944336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

117 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

118 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

119 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

120 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

121 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

122 (55.789947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

123 (514.03045654297): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 70491.075515747): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (674.96299743652): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792192 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792192 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 10838.031768799): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (100.13580322266): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (70.095062255859): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (512.83836364746): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (52.213668823242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (616.07360839844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (468.01567077637): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (56.982040405273): SELECT name FROM jos_deeppockets WHERE id=214

139 (39.100646972656): SELECT name FROM jos_deeppockets WHERE id=214

140 (803.94744873047): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (766.03889465332): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

143 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

144 (!!!!! 11353.969573975): TRUNCATE TABLE jos_trademed_module

145 (118.97087097168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792192 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (61.03515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792192 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (717.8783416748): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

150 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

151 (!!!!! 1580.9535980225): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

153 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

154 (54.836273193359): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792192 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792192 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (38.862228393555): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

157 (62.942504882812): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (205.99365234375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

159 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792192 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792192 AND published='1' LIMIT 1

160 (98.943710327148): select jos_twitters.link from jos_twitters where cat=10

161 (36.001205444336): select jos_facebook.link from jos_facebook where cat=10

162 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

163 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

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