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Artificial Intelligence Tool Improves Accuracy of Breast Cancer Imaging

By MedImaging International staff writers
Posted on 28 Sep 2021

Image: Breast ultrasound images show cancer (at left, as dark spot in center and, at right, in red, as highlighted by a computer) (Photo courtesy of Nature Communications)

A computer program trained to see patterns among thousands of breast ultrasound images can aid physicians in accurately diagnosing breast cancer, a new study shows.

When tested separately on 44,755 already completed ultrasound exams, the artificial intelligence (AI) tool developed by researchers at NYU Langone Health (New York, NY, USA) improved radiologists’ ability to correctly identify the disease by 37% and reduced the number of tissue samples, or biopsies, needed to confirm suspect tumors by 27%. The AI analysis is believed to be the largest of its kind, involving 288,767 separate ultrasound exams taken from 143,203 women treated at NYU Langone hospitals between 2012 and 2018.

Ultrasound exams use high-frequency sound waves passing through tissue to construct real-time images of breast or other tissues. Although not generally used as a breast cancer screening tool, it has served as an alternative to mammography or follow-up diagnostic tests for many women. Ultrasound is cheaper, more widely available in community clinics, and does not involve exposure to radiation, the researchers say. Moreover, ultrasound is better than mammography for penetrating dense breast tissue and distinguishing packed but healthy cells from compact tumors. However, the technology has also been found to result in too many false diagnoses of breast cancer, producing anxiety and unnecessary procedures for women. Some studies have shown that a majority of breast ultrasound exams indicating signs of cancer turn out to be noncancerous after biopsy.

For the study, more than half of ultrasound breast examinations were used to create the computer program. Ten radiologists then each reviewed a separate set of 663 breast exams, with an average accuracy of 92%. When aided by the AI model, their average accuracy in diagnosing breast cancer improved to 96%. All diagnoses were checked against tissue biopsy results. The researchers caution that while their initial results are promising, the team only looked at past exams in their latest analysis, and clinical trials of the tool in current patients and real-world conditions are needed before it can be routinely deployed. The team also plan to refine the AI software to include additional patient information, such as a woman’s added risk from having a family history or genetic mutation tied to breast cancer, which was not included in their latest analysis.

“Our study demonstrates how artificial intelligence can help radiologists reading breast ultrasound exams to reveal only those that show real signs of breast cancer and to avoid verification by biopsy in cases that turn out to be benign,” said study senior investigator Krzysztof J. Geras, PhD.

“If our efforts to use machine learning as a triaging tool for ultrasound studies prove successful, ultrasound could become a more effective tool in breast cancer screening, especially as an alternative to mammography, and for those with dense breast tissue,” said study co-investigator and radiologist Linda Moy, MD, a professor of radiology at NYU Grossman School of Medicine and a member of Perlmutter Cancer Center. “Its future impact on improving women’s breast health could be profound.”

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66 (49.114227294922): select jos_google_plus.link from jos_google_plus where cat=10

67 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

68 (34.809112548828): SELECT fid FROM jos_deeppockets WHERE id=294789827 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294789827 AND published='1' LIMIT 1

69 (30.994415283203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (281.09550476074): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294789827 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (226.02081298828): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294789827 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (126.83868408203): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (107.0499420166): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 1660.1085662842): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (86.069107055664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (50.067901611328): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294789827 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (28.848648071289): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294789827 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (32.901763916016): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (730.03768920898): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (78.916549682617): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (715.01731872559): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

105 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

106 (113.01040649414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294789827 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (886.20185852051): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294789827 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (794.88754272461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

109 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

110 (181.91337585449): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294789827 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (669.00253295898): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294789827 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (554.08477783203): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (355.00526428223): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

115 (55.789947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

116 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

117 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

118 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

119 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

120 (334.02442932129): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 54105.997085571): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (134.94491577148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

123 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

124 (489.95018005371): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294789827 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294789827 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 691828.96614075): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 3983.0207824707): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (364.06517028809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (394.82116699219): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (195.98007202148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (338.07754516602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (396.0132598877): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (143.05114746094): SELECT name FROM jos_deeppockets WHERE id=214

136 (32.186508178711): SELECT name FROM jos_deeppockets WHERE id=214

137 (503.0632019043): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (425.81558227539): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

140 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

141 (!!!!! 6513.1187438965): TRUNCATE TABLE jos_trademed_module

142 (!!!!! 3982.0671081543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294789827 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (154.97207641602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294789827 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (504.97055053711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

147 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

148 (!!!!! 1070.9762573242): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

150 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

151 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294789827 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294789827 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (473.0224609375): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

153 (!!!!! 1145.1244354248): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

154 (41.961669921875): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

156 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789827 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789827 AND published='1' LIMIT 1

157 (39.100646972656): select jos_twitters.link from jos_twitters where cat=10

158 (25.98762512207): select jos_facebook.link from jos_facebook where cat=10

159 (25.98762512207): select jos_google_plus.link from jos_google_plus where cat=10

160 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

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