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Implantable Ultrasound Biosensor Monitors pH Fluctuations

By MedImaging International staff writers
Posted on 05 May 2020
Image: Coated Silica cores change in response to Ph, which can be detected by ultrasound (Photo courtesy of Monash University)
Image: Coated Silica cores change in response to Ph, which can be detected by ultrasound (Photo courtesy of Monash University)
A new study reveals how a small insertable biosensor emits diagnostic signals that can be detected by common ultrasound scanners.

Developed at Monash University (Melbourne, Australia) and the Baker IDI Heart and Diabetes Institute (Melbourne, Australia), the solid nanoparticle sensors are designed to alter their stiffness in response to pH changes. The biosensor transmits the measured data by then modifying ultrasound contrast scanning signals. The sensors are made of a Silica (SiO2) core coated with pH-responsive polymethacrylic acid (PMASH) in a layer-by-layer approach, supervised via transmission electron and confocal laser scanning microscopy. The sensor is then covered in a porous organosilica shell.

The researchers subsequently confirmed the pH-dependent shrinkage and swelling of the PMASH layer, successfully demonstrating that reduction in pH below healthy physiological levels resulted in significant increases in ultrasound contrast, as measured in gel phantoms, mouse cadaver tissue, and in live mice. According to the researchers, more complex markers, such as oxygen (as an indicator of stroke injury) or disease-related proteins might also be detected in the future using similar ultrasound biomarkers. The study was published on March 23, 2020, in ACS Sensors.

“Our goal is to give clinicians the power of being able to have a patient sit in a chair and, as they are infusing the drugs, use commonly available ultrasound to monitor drug levels or organ response in real-time, adjusting dosages as a function of the patient’s needs,” said senior author Simon Corrie, PhD, of the department of chemical engineering at Monash University. “The technology has been tested in an animal model to detect changes in pH levels. We hope to now continue testing in animal models to determine whether it can accurately monitor rapidly changing pH levels, initially focusing on cancer and stroke.”

While a range of biosensors have been designed for optical, photoacoustic, and magnetic resonance imaging (MRI) modalities, various technical challenges have hindered the development of ultrasound biosensors, even though ultrasound is widely available, portable, safe, and capable of both surface and deep tissue imaging.

Related Links:
Monash University
Baker IDI Heart and Diabetes Institute


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96 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (394.82116699219): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 5682.9452514648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
105 (!!!!! 4050.9700775146): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
106 (332.11708068848): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294782159 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (!!!!! 1062.8700256348): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294782159 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (660.18104553223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
109 (171.89979553223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
110 (397.92060852051): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294782159 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (633.95500183105): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294782159 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (833.98818969727): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (!!!!! 5296.9455718994): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (654.93583679199): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
115 (104.18891906738): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
116 (715.01731872559): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
117 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
118 (552.17742919922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
119 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
120 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
121 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
122 (660.89630126953): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 51558.017730713): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (!!!!! 3621.8166351318): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294782159 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294782159 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 20134.925842285): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (81.062316894531): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (869.9893951416): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (79.154968261719): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (466.82357788086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (59.127807617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (753.16429138184): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (40.769577026367): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (!!!!! 1618.8621520996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (902.17590332031): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (463.00888061523): SELECT name FROM jos_deeppockets WHERE id=214
138 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=214
139 (535.01129150391): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (642.06123352051): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (!!!!! 4464.864730835): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
142 (!!!!! 3844.0227508545): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
143 (!!!!! 13746.976852417): TRUNCATE TABLE jos_trademed_module
144 (!!!!! 4021.167755127): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294782159 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (552.17742919922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294782159 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (!!!!! 1455.0685882568): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (282.04917907715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (!!!!! 1913.0706787109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
149 (244.140625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
150 (!!!!! 6723.165512085): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (!!!!! 1594.066619873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
152 (455.14106750488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
153 (549.0779876709): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294782159 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294782159 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (854.0153503418): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
155 (42.200088500977): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
156 (241.04118347168): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (574.11193847656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
158 (161.88621520996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782159 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782159 AND published='1' LIMIT 1
159 (309.94415283203): select jos_twitters.link from jos_twitters where cat=10
160 (!!!!! 1340.1508331299): select jos_facebook.link from jos_facebook where cat=10
161 (190.01960754395): select jos_google_plus.link from jos_google_plus where cat=10
162 (107.0499420166): select jos_linkedin.link from jos_linkedin where cat=10