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Focal Ultrasound Regenerates Alzheimer's Patients’ Brains

By MedImaging International staff writers
Posted on 22 Jan 2020

Image: Clinical sonication can help reverse Alzheimer’s disease (Photo courtesy of Storz Medical)

A new navigated ultrasound focal brain therapy can activate neurons to help regenerate brain functions in Alzheimer's disease (AD), claims a new study.

Developed at the Medical University of Vienna (MedUni; Austria), Storz Medical (Tägerwilen, Switzerland), the Center for Movement Disorders (Bad Krozingen, Germany), transcranial pulse stimulation (TPS) is a clinical sonication technique based on ultrashort ultrasound pulses which markedly differ from existing focused ultrasound techniques, as the pulse emitted by the ultrasound device is 3-5 mm wide, and approximately three cm long. An accurate "map" is first of all made of the patient's brain using magnetic resonance imaging (MRI).

The TPS pulse causes short-term membrane changes in the brain cells, affecting the concentration of transmitters and other biochemical substances. This results in activation of brain neurons and the development of compensatory networks that improve brain function. In a clinical pilot study involving 35 patients with AD, neuropsychological scores improved significantly after TPS treatment, and the improvement lasted up to three months, correlating with an upregulation of the memory network, as evidenced by functional MRI (fMRI) data. The study was published on December 23, 2019, in Advanced Science.

“For the first time in the world, TPS enables us to penetrate into all areas of the brain by means of an ultrasound pulse delivered directly to the skull in a non-invasive, painless procedure, during which the patient is fully conscious, and to specifically target particular areas of the brain and stimulate them,” said lead author Roland Beisteiner, MD, of MEdUni. “It is like starting up an old engine again. Those neurons that are still activatable show marked improvements after the procedure. The decline in performance is slowed down.”

TPS was delivered using the Storz Neurolith system using an ergonomic handpiece that minimizes hand fatigue, facilitating treatment when working directly on the patient. A coupling surface adapts to any shape of head, making the treatment with focused pulses simple and efficient. Biological effects of TPS include increased cell permeability, stimulation of mechanosensitive ion channels, release of nitric oxide (which leads to vasodilation), increased metabolic activity, stimulation of vascular growth factors (VEGF 3 and 4).

Related Links:
Medical University of Vienna
Storz Medical
Center for Movement Disorders

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62 (506.87789916992): SELECT fid FROM jos_deeppockets WHERE id=294780609 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294780609 AND published='1' LIMIT 1

63 (60.081481933594): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (61.03515625): select jos_twitters.link from jos_twitters where cat=10

65 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

66 (33.140182495117): select jos_google_plus.link from jos_google_plus where cat=10

67 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

68 (33.855438232422): SELECT fid FROM jos_deeppockets WHERE id=294780609 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294780609 AND published='1' LIMIT 1

69 (32.186508178711): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (254.15420532227): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294780609 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (153.0647277832): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294780609 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (41.007995605469): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 3867.8646087646): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294780609 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (109.91096496582): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294780609 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 2294.0635681152): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (608.92105102539): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 3139.0190124512): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

105 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

106 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294780609 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (516.89147949219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294780609 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

109 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

110 (67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294780609 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 2059.9365234375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294780609 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 5889.892578125): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (478.02925109863): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1418.1137084961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

115 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

116 (!!!!! 2100.944519043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

117 (144.00482177734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

118 (!!!!! 1266.0026550293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

119 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

120 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

121 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

122 (460.86311340332): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 124360.79978943): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 3824.9492645264): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294780609 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294780609 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1056.9095611572): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (166.17774963379): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (237.94174194336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (69.141387939453): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (100.13580322266): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (389.09912109375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (263.92936706543): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (64.849853515625): SELECT name FROM jos_deeppockets WHERE id=214

138 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=214

139 (771.99935913086): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (779.15191650391): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (141.85905456543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

142 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

143 (!!!!! 13762.950897217): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1254.0817260742): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294780609 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (761.03210449219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294780609 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (519.0372467041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (488.9965057373): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 1480.1025390625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

149 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

150 (!!!!! 1765.0127410889): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

152 (152.8263092041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

153 (229.83551025391): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294780609 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294780609 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (39.100646972656): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (41.961669921875): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

158 (248.90899658203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294780609 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294780609 AND published='1' LIMIT 1

159 (305.8910369873): select jos_twitters.link from jos_twitters where cat=10

160 (!!!!! 1163.9595031738): select jos_facebook.link from jos_facebook where cat=10

161 (68.902969360352): select jos_google_plus.link from jos_google_plus where cat=10

162 (45.061111450195): select jos_linkedin.link from jos_linkedin where cat=10

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