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Focused Ultrasound Scalpel Could Destroy Liver Tumors

By MedImaging International staff writers
Posted on 23 Mar 2017

Image: Focused ultrasound could treat tumors in moving organs, such as the liver (Photo courtesy of Fraunhofer MEVIS).

A new technique that allows an ultrasound (US) beam to be refocused in synchronization with breathing could help treat liver tumors more effectively, while sparing surrounding healthy tissue.

The technique, developed by the Fraunhofer Institute for Medical Image Computing and SINTEF as part of the clinical translation of patient-specific planning and conducting of FUS treatment in moving organs (TRANS-FUSIMO) project, is based on real-time, predictive software that establishes liver position by magnetic resonance imaging (MRI) every tenth of a second, and calculates movement. The data is then sent to an US transducer equipped with more than 1,000 small transmitters that sits on the patient's stomach.

The transducer focuses the individual US transmission beams so that their waves converge precisely at a point as small as a grain of rice, resulting in a destructive effect at the focal point; the transmitters that face the ribs remain inactivated throughout the process. The MRI scanner controls the entire process, measuring the temperature in the liver and ensuring that the correct foci are sufficiently heated. The therapy is completely non-invasive and can be performed without anesthesia, and there are no wounds. A study describing preliminary results was presented at the annual European Radiology Congress (ECR), held during March 2017 in Vienna (Austria).

“Generating an image of the liver's position every tenth of a second is not fast enough to reliably direct the ultrasound beam. This is why we developed software that can see into the immediate future and calculate the next position of the treated region,” said mathematician Sabrina Haase, project manager at MEVIS. “The program determines the path for the focused ultrasound waves to reach the liver tumor even when the patient moves while breathing. Developing the software was quite challenging: it must run both highly reliably and in real time.”

“Patients with abdominal tumors must undergo multiple invasive interventions; MR-guided focused ultrasound can offer a genuine alternative to such interventions,” said radiologist Professor Mario Bezzi, MD, of La Sapienza University, who will participate in the clinical part of the TRANS-FUSIMO project. “The new therapy control system developed in the TRANS-FUSIMO project will be extraordinarily helpful in the clinical routine by allowing tumors to be destroyed very precisely and to guide the entire procedure effectively.”

High-intensity focused ultrasound (HIFU) technology is based on nonlinear mathematical optimization methods to analyze and simulate the propagation of sound in material. The information is then used to enhance the shape of an acoustic lens so that that US pressure is focused precisely on the location of the tissue to be ablated, while the surrounding tissue retains as little damage as possible.

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61 (!!!!! 19012.212753296): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 1716.136932373): SELECT fid FROM jos_deeppockets WHERE id=294768582 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294768582 AND published='1' LIMIT 1

63 (408.17260742188): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (447.98851013184): select jos_twitters.link from jos_twitters where cat=10

65 (226.02081298828): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 1129.150390625): select jos_google_plus.link from jos_google_plus where cat=10

67 (61.03515625): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 1715.1832580566): SELECT fid FROM jos_deeppockets WHERE id=294768582 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294768582 AND published='1' LIMIT 1

69 (92.029571533203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (951.05171203613): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294768582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 3220.0813293457): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294768582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (527.85873413086): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (595.0927734375): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (252.00843811035): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (254.86946105957): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (138.0443572998): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (293.01643371582): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (796.79489135742): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (!!!!! 1181.8408966064): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (478.02925109863): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 4241.943359375): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294768582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (540.97175598145): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294768582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (58.889389038086): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 1115.083694458): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (588.89389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (921.01097106934): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (248.90899658203): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (224.11346435547): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 1714.9448394775): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (816.82205200195): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (284.91020202637): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 6211.9960784912): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

105 (!!!!! 7981.0619354248): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

106 (!!!!! 3647.0890045166): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294768582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 1114.8452758789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294768582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 6122.1122741699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

109 (!!!!! 2954.0061950684): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

110 (!!!!! 1004.2190551758): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294768582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1470.8042144775): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294768582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (572.91984558105): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (550.98533630371): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1749.0386962891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

115 (263.92936706543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

116 (486.85073852539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

117 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

118 (!!!!! 1373.0525970459): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

119 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

120 (!!!!! 1626.9683837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

121 (!!!!! 2168.8938140869): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

122 (!!!!! 7067.9187774658): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 53637.981414795): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 7055.0441741943): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294768582 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294768582 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 26297.092437744): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 18996.000289917): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (72.002410888672): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (215.05355834961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (993.01338195801): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (72.956085205078): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (390.05279541016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (52.213668823242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 6135.9405517578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (746.01173400879): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 2027.0347595215): SELECT name FROM jos_deeppockets WHERE id=214

138 (80.108642578125): SELECT name FROM jos_deeppockets WHERE id=214

139 (!!!!! 2636.9094848633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1076.9367218018): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1617.9084777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

142 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

143 (!!!!! 15258.073806763): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 6988.0485534668): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294768582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 1296.9970703125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294768582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (613.92784118652): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 3388.1664276123): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

149 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

150 (!!!!! 1689.1956329346): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

152 (!!!!! 1254.0817260742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

153 (!!!!! 3698.8258361816): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294768582 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294768582 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (109.91096496582): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (46.968460083008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (69.856643676758): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 3123.9986419678): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

158 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294768582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294768582 AND published='1' LIMIT 1

159 (271.08192443848): select jos_twitters.link from jos_twitters where cat=10

160 (82.969665527344): select jos_facebook.link from jos_facebook where cat=10

161 (293.01643371582): select jos_google_plus.link from jos_google_plus where cat=10

162 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

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