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Targeted Ultrasound Reboots Brain Following Coma

By MedImaging International staff writers
Posted on 08 Sep 2016

Image: A 3D reconstruction of patient’s head with transducer (L); axial view of the transducer and approximate thalamic target (R) (Photo courtesy of Martin Monti/ UCLA).

Ultrasonic stimulation in order to excite the neurons in the thalamus could be used to treat severe brain injury, according to a new study.

Researchers at the University of California, Los Angeles (UCLA; USA) used a low-intensity focused ultrasound pulsation technique in order to stimulate the brain of a 25-year-old man recovering from a coma. The ultrasonic pulsations were delivered using a small transducer to create a small sphere of acoustic energy that was aimed at the thalamus region to excite brain tissue. The researchers placed the transducer at the side of the man's head, and activated it 10 times for 30 seconds each during a 10-minute period.

The researchers reported that before the procedure began, the man showed only minimal signs of being conscious and of understanding speech, performing only small, limited movements when asked. But by the next day, his responses had improved measurably; three days later, the patient had regained full consciousness and full language comprehension, and could reliably communicate by nodding or shaking his head and making hand gestures. The study was published on July 22, 2016, in Brain Stimulation.

“The changes were remarkable. It's almost as if we were jump-starting the neurons back into function,” said lead author Martin Monti, MD, PhD, a UCLA associate professor of psychology and neurosurgery. “Until now, the only way to achieve this was a risky surgical procedure known as deep brain stimulation, in which electrodes are implanted directly inside the thalamus. Our approach directly targets the thalamus but is noninvasive.”

The thalamus is a midline egg-shaped symmetrical structure within the vertebrate brain, situated between the cerebral cortex and the midbrain. It serves as the brain's central hub for processing information, relaying sensory and motor signals to the cerebral cortex, and participating in the regulation of consciousness, sleep, and alertness. The new technique targets the thalamus, since people whose mental function has been deeply impaired after a coma show diminished thalamus performance.

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62 (!!!!! 1533.9851379395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

63 (!!!!! 8569.9558258057): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

64 (!!!!! 7803.9169311523): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (!!!!! 4516.1247253418): SELECT fid FROM jos_deeppockets WHERE id=294765936 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294765936 AND published='1' LIMIT 1

66 (!!!!! 5902.0519256592): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

67 (!!!!! 3046.989440918): select jos_twitters.link from jos_twitters where cat=10

68 (!!!!! 2917.0513153076): select jos_facebook.link from jos_facebook where cat=10

69 (!!!!! 1554.012298584): select jos_google_plus.link from jos_google_plus where cat=10

70 (285.86387634277): select jos_linkedin.link from jos_linkedin where cat=10

71 (710.01052856445): SELECT fid FROM jos_deeppockets WHERE id=294765936 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294765936 AND published='1' LIMIT 1

72 (79.870223999023): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

73 (!!!!! 8064.0316009521): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765936 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (!!!!! 7701.8737792969): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765936 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (!!!!! 8119.1062927246): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (562.90626525879): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (211.00044250488): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (197.8874206543): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (704.05006408691): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (290.1554107666): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (!!!!! 4034.9960327148): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (826.12037658691): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (!!!!! 1080.0361633301): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (329.01763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (225.06713867188): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (!!!!! 2059.9365234375): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765936 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (298.97689819336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765936 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (285.86387634277): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (!!!!! 4153.0132293701): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 2096.1761474609): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (469.92301940918): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (776.05247497559): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (!!!!! 1603.8417816162): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 3973.0072021484): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (!!!!! 1003.0269622803): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (598.90747070312): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 2861.0229492188): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (!!!!! 3324.031829834): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (293.01643371582): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (!!!!! 1089.0960693359): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (!!!!! 3855.9436798096): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

108 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

109 (59.843063354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765936 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765936 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 4173.9940643311): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

112 (615.11993408203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

113 (!!!!! 4586.935043335): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294765936 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (!!!!! 7462.9783630371): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294765936 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (628.94821166992): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (434.87548828125): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (!!!!! 1570.9400177002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

118 (309.94415283203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

119 (!!!!! 4918.098449707): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

120 (265.12145996094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

121 (962.0189666748): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

122 (509.97734069824): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

123 (!!!!! 1816.987991333): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

124 (129.22286987305): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

125 (499.01008605957): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 59024.095535278): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (!!!!! 2375.1258850098): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765936 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765936 AND type='deeppockets_item' AND published='1' LIMIT 1

128 (102.04315185547): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (355.00526428223): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (!!!!! 3294.9447631836): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (320.9114074707): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (!!!!! 2041.1014556885): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (563.8599395752): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (!!!!! 3123.9986419678): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (!!!!! 2537.0121002197): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (!!!!! 1224.9946594238): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (!!!!! 3497.1237182617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (674.96299743652): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (!!!!! 2080.9173583984): SELECT name FROM jos_deeppockets WHERE id=214

141 (574.11193847656): SELECT name FROM jos_deeppockets WHERE id=214

142 (890.01655578613): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (821.11358642578): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (385.99967956543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

145 (506.87789916992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

146 (!!!!! 21971.940994263): TRUNCATE TABLE jos_trademed_module

147 (!!!!! 7364.03465271): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765936 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (87.976455688477): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765936 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (!!!!! 1592.8745269775): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (332.11708068848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (!!!!! 4396.915435791): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

152 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

153 (!!!!! 2990.9610748291): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

155 (!!!!! 1008.9874267578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

156 (42.915344238281): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765936 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765936 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (34.093856811523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

158 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

159 (339.03121948242): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (361.91940307617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

161 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765936 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765936 AND published='1' LIMIT 1

162 (!!!!! 1489.8777008057): select jos_twitters.link from jos_twitters where cat=10

163 (473.0224609375): select jos_facebook.link from jos_facebook where cat=10

164 (112.05673217773): select jos_google_plus.link from jos_google_plus where cat=10

165 (179.05235290527): select jos_linkedin.link from jos_linkedin where cat=10

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