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Ultrasound Provides Insights into Abdominal Aortic Aneurysms

By MedImaging International staff writers
Posted on 28 Oct 2014

Image: Purdue University researchers are using ultrasound images like this one to study abdominal aortic aneurysms, a potentially fatal condition that is the 13th leading cause of death in the United States (Photo courtesy of Purdue University/Weldon School of Biomedical Engineering).

Researchers are assessing the effectiveness of the use of ultrasound to study lethal abdominal aortic aneurysms (AAAs), a bulging of the aorta that is typically fatal when it ruptures, and for which there is no effective medical treatment.

Abdominal aortic aneurysms are the 13th leading cause of death in the United States, killing about 15,000 yearly. “Most of the time people don’t even know it’s there, but if it does rupture they have internal bleeding from the largest artery in the body,” said Craig Goergen, an assistant professor in Purdue University’s (West Lafayette, IN, USA) Weldon School of Biomedical Engineering. “Eighty percent of the time the patient dies before getting to the hospital.”

Researchers have used a technique called high-frequency small animal ultrasound to measure alterations in the progression of abdominal aortic aneurysms in lab animals. By learning more about aneurysms at the molecular level, researchers might be able to develop drug or stem cell therapies to keep them from growing larger, according to Dr. Goergen.

New findings were presented on October 25, 2014, by doctoral student Evan Phillips during the Biomedical Engineering Society’s annual meeting in San Antonio (TX, USA). The researchers are able to monitor small changes in the vessel as the aneurysm forms. Ultrasound imaging allows for visualization of the arterial layers that frequently separate from each other while the vessel grows. “The development of these aneurysms is a multifaceted process that has not been fully characterized, and no therapeutics have proven to effectively prevent aneurysm progression,” Dr. Goergen said. “What we want to do is understand what causes aneurysms to form and grow so that we can then develop better strategies to prevent that from happening.”

The ultrasound technique also uses color Doppler imaging, making it possible for researchers to collect color-coded blood flow data showing the direction and speed of circulation, both of which are factors that might influence how aneurysms develop and expand. The frequency of a wave changes as it moves toward or away from the observer, a phenomenon known as the Doppler effect. Color Doppler images reveal red flow moving toward the ultrasound transducer and blue flow moving away. The efforts are laying a basis for additional studies that might use these strategies in a clinical setting or to investigate potential therapeutics, according to Dr. Goergen.

Human aortic aneurysms typically begin at 3–4 cm in diameter and are located in the abdomen below the kidneys. The aorta extends from the heart through the body and ultimately branches into two smaller arteries leading to the legs. Most at risk are older men who have high blood pressure and a history of smoking. Men over 65 who fit this profile are advised to contact their doctor about ultrasound screening to determine if they have an aneurysm.

“Unless you feel a pulsating mass, develop unusual back pain, or are screened with ultrasound, most people don’t even discover that they have it. If you are diagnosed, most surgeons won’t treat aneurysms less than 4 cm. Unfortunately, there is no medicine that can prevent aneurysms from growing,” Dr. Goergen said. “Doctors can give you statins to lower your cholesterol levels or anti-hypertension medication to lower your blood pressure, but there are no medications that can directly prevent aneurysm expansion.”

However, researchers can analyze laboratory animals that mimic conditions in humans to provide insights into the mechanisms behind aneurysms. The group led by Dr. Goergen used ultrasound imaging to quantify changes over a four-week period as aneurysms developed and expanded in mice and rats. “We’re doing three-dimensional ultrasound that can reconstruct that whole aorta,” Dr. Goergen said.

Because this technique is noninvasive, it may ultimately be used on humans to diagnose and monitor aneurysm progression.

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58 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

59 (159.02519226074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

60 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

61 (!!!!! 9732.0079803467): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 3826.1413574219): SELECT fid FROM jos_deeppockets WHERE id=294755396 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294755396 AND published='1' LIMIT 1

63 (89.883804321289): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (!!!!! 3560.0662231445): select jos_twitters.link from jos_twitters where cat=10

65 (78.916549682617): select jos_facebook.link from jos_facebook where cat=10

66 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

67 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

68 (45.7763671875): SELECT fid FROM jos_deeppockets WHERE id=294755396 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294755396 AND published='1' LIMIT 1

69 (35.04753112793): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (537.87231445312): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755396 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (319.00405883789): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755396 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (41.007995605469): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (106.0962677002): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755396 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (44.822692871094): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755396 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (51.975250244141): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (91.791152954102): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

105 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

106 (!!!!! 3733.8733673096): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294755396 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (689.02969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294755396 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

109 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

110 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294755396 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (627.99453735352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294755396 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (702.85797119141): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (475.88348388672): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

115 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

116 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

117 (192.88063049316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

118 (230.07392883301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

119 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

120 (420.09353637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

121 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

122 (391.96014404297): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 51333.904266357): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (832.08084106445): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755396 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755396 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 19091.129302979): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (58.889389038086): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (239.13383483887): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (603.91426086426): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (446.08116149902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (277.99606323242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (413.89465332031): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 4309.1773986816): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (873.08883666992): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (590.08598327637): SELECT name FROM jos_deeppockets WHERE id=214

138 (43.153762817383): SELECT name FROM jos_deeppockets WHERE id=214

139 (550.0316619873): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (428.91502380371): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

142 (519.0372467041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

143 (!!!!! 10321.140289307): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1070.0225830078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294755396 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (178.81393432617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294755396 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 2205.1334381104): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 7477.0450592041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 7734.7755432129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

149 (!!!!! 7992.9828643799): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

150 (!!!!! 4977.9415130615): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (684.02290344238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

152 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

153 (373.84033203125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755396 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755396 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (115.87142944336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (38.862228393555): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (296.11587524414): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (402.92739868164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

158 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755396 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755396 AND published='1' LIMIT 1

159 (262.97569274902): select jos_twitters.link from jos_twitters where cat=10

160 (172.85346984863): select jos_facebook.link from jos_facebook where cat=10

161 (46.014785766602): select jos_google_plus.link from jos_google_plus where cat=10

162 (80.108642578125): select jos_linkedin.link from jos_linkedin where cat=10

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