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Clot-Buster Ultrasound Device May Become Best Treatment Option for Stroke Patients

By MedImaging International staff writers
Posted on 01 Sep 2014

Image: UAMS researcher William Culp, MD, (right), and Doug Wilson of UALR (left) have developed a device to treat stroke (Photo courtesy of UAMS/UALR Office of Communications).

A new device is being developed to treat stroke more effectively. The new technology fits on the head similar to a halo and delivers therapy to rapidly bust clots that cause stroke.

The device was developed by William Culp, MD, professor of radiology, surgery and neurology and vice chairman of research at the University of Arkansas for Medical Sciences (UAMS; Little Rock, USA), and Dr. Doug Wilson, assistant director at the Graduate Institute of Technology at UALR. One feature of Dr. Culp’s research included using ultrasound scanning in combination with the clot-busting drug tissue plasminogen activator (t-PA).

While studying the treatment to dissolve clots in blood vessels, Dr. Culp realized one problem is getting the ultrasound to operate through the skull. Ultrasound can be delivered anywhere in a patient’s body unless the waves hit something hard similar to bone or something very soft, similar to air. “We realized we had trouble delivering ultrasound to the vessels at the base of the brain,” Dr. Culp stated. “The skull stopped the ultrasounds.”

Dr. Culp collaborated with Dr. Wilson to devise strategies about how to get the ultrasound waves to reach the clot in stroke patients. “This is a great example of how faculty at both schools can partner to develop new technologies. The success of this research will foster ties between the two campuses,” Dr. Wilson said. “It makes me extremely proud to have contributed to a product with potential to help many people,” he said.

Dr. Culp received a grant from UAMS that provided him with the materials he needed to experiment. Wilson and Culp completed their first patent for “ultrasound for augmented clot lysis” in 2005. The patent was licensed in 2006 and has been in development by Cerevast Therapeutics (Redmond, WA, USA).

The ClotBust ER has 16 transducers distributed around the inside—designed to line up with the thin points in the skull: the temples and the foramen magnum in the base of the skull. This allows the ultrasound waves to move through the brain without interruption. After the patient is administered an intravenous (IV) solution containing t-PA, the circular device is positioned onto the patient’s head like a sports visor or halo. “The idea is to deliver ultrasound wherever the clot is and where the IV t-PA is working,” Dr. Culp said. “It makes t-PA work better—improving the clot-busting drug by 40% or 50%. It’s like taking a cooking pot and stirring it. The ultrasound stirs the drug around, making it work better.” The clot disappears more rapidly. “If we resupply blood, we resupply oxygen. The brain recovers quicker. Quicker is, of course, better,” Dr. Culp said.

Now in a phase three human trial, the ClotBust ER has been tested in more than 300 patients. None of the results have come back with substantial adverse effects. Since the trial periods began, 66 other university sites have signed up to be included in the testing. The device will also soon be available at some sites of the statewide stroke network called AR SAVES while it is in trial.

“Our goal is to test 840 patients,” Dr. Culp said. “But right now, the results are looking so promising that it is possible testing could be stopped early if the safety committee determines we don’t have to go any further.” He is hopeful the device will be approved by the start of 2016. “We’re here to find a cure,” Dr. Culp said. “This device is just one part of many things. We mustn’t forget prevention.”

Dr. Culp noted that there has been a significant decrease in strokes in the United States and in Arkansas during the past 20 years. This is especially good news for the state Arkansas, which ranks highest in the United States for rate of stroke deaths. Dr. Culp believes Americans generally now have a better awareness of the disease. “But for those 800,000 people who will have a stroke in the United States every year, we still have to have good therapy,” Dr. Culp concluded. “This device may well be the next step.”

Related Links:
University of Arkansas for Medical Sciences
Cerevast Therapeutics

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54 (663.04206848145): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

55 (247.00164794922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754260 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

56 (374.07875061035): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754260 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 2044.9161529541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

58 (!!!!! 1806.0207366943): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

59 (!!!!! 7203.8173675537): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

60 (!!!!! 1018.0473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

61 (!!!!! 11075.973510742): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 2049.9229431152): SELECT fid FROM jos_deeppockets WHERE id=294754260 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294754260 AND published='1' LIMIT 1

63 (383.85391235352): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (!!!!! 1490.1161193848): select jos_twitters.link from jos_twitters where cat=10

65 (56.982040405273): select jos_facebook.link from jos_facebook where cat=10

66 (212.9077911377): select jos_google_plus.link from jos_google_plus where cat=10

67 (224.82872009277): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 2625.9422302246): SELECT fid FROM jos_deeppockets WHERE id=294754260 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294754260 AND published='1' LIMIT 1

69 (216.00723266602): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (!!!!! 1971.0063934326): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754260 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (477.07557678223): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754260 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1036.1671447754): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1205.9211730957): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (182.15179443359): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (375.98609924316): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (294.92378234863): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (117.06352233887): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (439.88227844238): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (234.84230041504): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (478.98292541504): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 1955.0323486328): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754260 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (241.99485778809): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754260 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 3703.1173706055): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (434.16023254395): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (247.95532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 3078.9375305176): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (301.83792114258): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 3583.9080810547): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (!!!!! 2119.0643310547): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (571.96617126465): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

105 (240.08750915527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

106 (!!!!! 1639.1277313232): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754260 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (396.9669342041): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754260 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1307.0106506348): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

109 (!!!!! 1481.0562133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

110 (!!!!! 7921.9341278076): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754260 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 5132.9135894775): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754260 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 7766.9620513916): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 7769.1078186035): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 7828.950881958): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

115 (!!!!! 8800.0297546387): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

116 (!!!!! 7590.0554656982): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

117 (!!!!! 8007.0495605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

118 (!!!!! 7714.0331268311): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

119 (!!!!! 7969.856262207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

120 (!!!!! 7786.9892120361): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

121 (!!!!! 7447.0043182373): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

122 (427.0076751709): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 69580.793380737): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 16227.006912231): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754260 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754260 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 23550.987243652): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 16195.058822632): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 10161.876678467): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (!!!!! 12525.081634521): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 6269.9317932129): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (!!!!! 1762.1517181396): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (921.01097106934): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (!!!!! 3192.1863555908): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (377.89344787598): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 5855.0834655762): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (451.80320739746): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (382.1849822998): SELECT name FROM jos_deeppockets WHERE id=214

138 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=214

139 (924.11041259766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (674.00932312012): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (981.80770874023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

142 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

143 (!!!!! 11595.964431763): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 5227.80418396): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754260 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 2608.060836792): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754260 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 2119.0643310547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 3216.028213501): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 2161.0260009766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

149 (137.0906829834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

150 (!!!!! 1677.0362854004): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 2690.0768280029): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

152 (!!!!! 1127.9582977295): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

153 (961.0652923584): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754260 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754260 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (509.02366638184): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (46.968460083008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (409.12628173828): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 4755.0201416016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

158 (134.94491577148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754260 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754260 AND published='1' LIMIT 1

159 (661.84997558594): select jos_twitters.link from jos_twitters where cat=10

160 (36.954879760742): select jos_facebook.link from jos_facebook where cat=10

161 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

162 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

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