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New Approaches for Transcanial Ultrasound Used for the Treatment of Brain Tumors and Targeted Drug Delivery

By MedImaging International staff writers
Posted on 17 Aug 2014
Image: Ultrasound image of the Circle of Willis (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
Image: Ultrasound image of the Circle of Willis (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
Image: Doppler ultrasound waveform of flow velocities in the middle cerebral artery (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
Image: Doppler ultrasound waveform of flow velocities in the middle cerebral artery (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
A study completed by a Finnish researcher provides new insights into the limitations and potential new directions for the future advancement of transcranial ultrasound therapy. Active research is ongoing in this field, which potentially can be applied to the treatment of brain tumors and targeted drug delivery.

The therapy modality has already been effectively applied to the treatment of neuropathic pain disorder and essential tremors. The benefits of transcranial ultrasound therapy include minimal invasiveness, because the treatment is delivered to the brain by transmitting ultrasound through the intact skull of the patient. The study focuses on two issues that may potentially restrict the applicability of transcranial ultrasound: skull-base heating and formation of standing-waves.

As the ultrasound beam encounters the skull bone, part of the beam’s energy is transferred into the skull as heat. In the study, it was found that the heating of the skull-base during transcranial ultrasound therapy can result in hazardous temperature elevations when the sonications are performed close to the skull-base. Three new approaches were developed in this study to counteract this potentially hazardous phenomenon.

However, standing waves are formed in the ultrasound field when waves reflect from the surface of the skull bone. During transcranial ultrasound therapy, the ultrasound amplitude can reach higher levels than intended if these reflections are not taken into account during the initial treatment planning. The study, a project that came out of a PhD thesis by Aki Pulkkinen, MSc, from the University of Eastern Finland (Joensuu), revealed that the formation of standing waves is greatly reduced when specifically designed large-area ultrasound transducers are used.

The study also introduces a model to numerically simulate clinical patient treatments performed with transcranial ultrasound therapy. The predictions produced by the model were compared to observations done in clinical patient trials performed earlier. The predictions were found to be of sufficient accuracy for an initial treatment planning. However, more accurate characterization of the acoustical and thermal parameters involved in transcranial ultrasound therapy is nonetheless required.

The Ph.D. thesis by Aki Pulkkinen, MSc, entitled Simulation Methods in Transcranial Ultrasound Therapy, is available online (please see Related Links below).

Related Links:

Simulation Methods in Transcranial Ultrasound Therapy
University of Eastern Finland


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90 (!!!!! 2724.8859405518): SELECT show_live FROM jos_com_show_setting LIMIT 1
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92 (882.86399841309): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (548.8395690918): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (406.98051452637): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (94.890594482422): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 9660.005569458): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
105 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
106 (!!!!! 1349.925994873): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753991 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (!!!!! 4328.0124664307): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753991 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (627.99453735352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
109 (216.00723266602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
110 (674.96299743652): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753991 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (396.0132598877): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753991 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (!!!!! 1317.024230957): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (595.0927734375): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (!!!!! 1725.9120941162): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
115 (137.0906829834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
116 (726.93824768066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
117 (!!!!! 1722.8126525879): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
118 (446.08116149902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
119 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
120 (504.0168762207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
121 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
122 (!!!!! 2367.9733276367): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 42383.909225464): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (!!!!! 1757.1449279785): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753991 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753991 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 18051.147460938): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (52.928924560547): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (592.94700622559): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (539.06440734863): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (643.96858215332): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (83.92333984375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (387.90702819824): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (119.92454528809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (408.88786315918): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (149.01161193848): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (654.93583679199): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (698.80485534668): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (163.07830810547): SELECT name FROM jos_deeppockets WHERE id=214
138 (211.95411682129): SELECT name FROM jos_deeppockets WHERE id=214
139 (696.89750671387): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (!!!!! 2187.967300415): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
142 (232.93495178223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
143 (!!!!! 14115.09513855): TRUNCATE TABLE jos_trademed_module
144 (!!!!! 2331.018447876): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753991 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (529.05082702637): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753991 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (!!!!! 2403.0208587646): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (367.16461181641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (!!!!! 3320.9323883057): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
149 (!!!!! 7716.178894043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
150 (!!!!! 7426.0234832764): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (!!!!! 4575.0141143799): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
152 (!!!!! 7882.833480835): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
153 (!!!!! 7786.0355377197): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753991 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753991 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (!!!!! 8005.1422119141): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
155 (!!!!! 7879.9724578857): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
156 (!!!!! 7108.9267730713): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (!!!!! 5957.8418731689): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
158 (931.97822570801): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753991 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753991 AND published='1' LIMIT 1
159 (277.99606323242): select jos_twitters.link from jos_twitters where cat=10
160 (269.88983154297): select jos_facebook.link from jos_facebook where cat=10
161 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10
162 (184.05914306641): select jos_linkedin.link from jos_linkedin where cat=10