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Focused Ultrasound Therapy Shows Potential in the Noninvasive Treatment of Thyroid Nodules and Breast Fibroadenomas

By MedImaging International staff writers
Posted on 22 Oct 2013

Image: The Echopulse device, designed for ultrasound therapy (Photo courtesy of Theraclion).

A French medical company has reported very positive initial clinical findings from a new study on the treatment of thyroid nodules, demonstrating the effectiveness of its Echopulse device in the treatment of this disorder.

Trials for the treatment of benign thyroid nodules with echotherapy were conducted on 20 patients at the University Hospital of Endocrinology (Sofia, Bulgaria). The treatment reduced the size of the nodules in all patients. The reduction in size at the six-month mark was a median of 52%. These findings showed the effectiveness and excellent tolerance of ultrasound therapy for this disorder and were presented at the second edition of the Focused Ultrasound Symposium, held in Rome (Italy), on October 10 and 11, 2013. Theraclion (Malakoff, France), a company specializing in advanced medical equipment for ultrasound therapy, also known as echotherapy, is the developer of the Echopulse device.

A thyroid nodule is a protuberance that develops on the thyroid gland and is typically benign. Surgical intervention is the conventional treatment when a nodule is suspect, malignant, or benign but increases in size or causes physical discomfort for the patient. “These results with echotherapy are very encouraging. The significant reduction in nodule size at the end of six months, with a 94% reduction in some cases, demonstrates that the Echopulse can offer an alternative therapy that is less burdensome to the patient,” said Prof. Roussanka Kovatcheva, from the University Hospital of Endocrinology.

Moreover, new results from trials conducted in the treatment of breast fibroadenoma also confirm the effectiveness of the technology. This benign tumor is the most widespread (10% of women will develop it in the course of their lives) and accounts for more than half of benign breast tumors. These trials were performed on 42 patients in France, at the American Hospital of Paris, the Hospital of Valenciennes, and the University Hospital of Lille, and in Bulgaria, at the University Hospital of Endocrinology in Sofia. Treatment of 51 fibroadenomas treated with high-intensity focused ultrasound (HIFU) led to a 71% average reduction in tumor volume one year after the procedure. Also at the 12-month mark, 92% of patients showed a volume reduction of more than 60% and resolution of symptoms. The treatment reduced the size of fibroadenomas in all patients.

“We are very pleased with these encouraging primary results on thyroid nodules and the confirmation of the efficacy of Echopulse in the treatment of breast fibroadenoma. Our technology enables patricians to offer an effective, noninvasive, and scarless alternative to their patients,” said Stefano Vagliani, CEO of Theraclion.

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59 (!!!!! 6761.7893218994): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

60 (142.09747314453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

61 (!!!!! 7253.885269165): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 2431.1542510986): SELECT fid FROM jos_deeppockets WHERE id=294748745 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294748745 AND published='1' LIMIT 1

63 (110.14938354492): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (48.160552978516): select jos_twitters.link from jos_twitters where cat=10

65 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

66 (33.140182495117): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 3329.9922943115): SELECT fid FROM jos_deeppockets WHERE id=294748745 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294748745 AND published='1' LIMIT 1

69 (!!!!! 3917.2172546387): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (499.96376037598): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294748745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (347.85270690918): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294748745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (46.968460083008): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (623.94142150879): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (!!!!! 2686.0237121582): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (895.02334594727): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (103.95050048828): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 2382.0400238037): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (113.96408081055): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 3798.0079650879): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (127.07710266113): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (120.87821960449): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294748745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (44.822692871094): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294748745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (47.206878662109): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1703.9775848389): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

105 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

106 (138.0443572998): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294748745 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (674.00932312012): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294748745 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (104.18891906738): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

109 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

110 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294748745 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (667.09518432617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294748745 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (661.13471984863): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 2612.1139526367): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (158.07151794434): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

115 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

116 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

117 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

118 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

119 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

120 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

121 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

122 (!!!!! 3439.9032592773): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 48336.982727051): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (642.06123352051): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294748745 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294748745 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 18867.015838623): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (91.075897216797): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (378.84712219238): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (60.796737670898): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (512.12310791016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 2616.1670684814): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (101.08947753906): SELECT name FROM jos_deeppockets WHERE id=214

138 (43.153762817383): SELECT name FROM jos_deeppockets WHERE id=214

139 (756.02531433105): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (506.87789916992): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

142 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

143 (!!!!! 14047.145843506): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 9989.0232086182): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294748745 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (132.08389282227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294748745 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (468.01567077637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 2019.8822021484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

149 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

150 (!!!!! 3372.1923828125): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

152 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

153 (!!!!! 2774.0001678467): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294748745 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294748745 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (106.0962677002): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (34.809112548828): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (!!!!! 3903.1505584717): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (180.95970153809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

158 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294748745 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294748745 AND published='1' LIMIT 1

159 (40.054321289062): select jos_twitters.link from jos_twitters where cat=10

160 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

161 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

162 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

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