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New Ultrasound Applications Detects Early Response to Pancreatic Cancer Therapy

By MedImaging International staff writers
Posted on 06 Mar 2013

Image: 3-D Ultrasound Molecular Imaging (USMI) images of nonresponder and responder pancreatic xenografts before (day 0) and after (day 2) treatment. The grayscale image shows a volume of the tumor and surrounding tissue. The green region is the molecular signal (Photo courtesy of the University of North Carolina).

In a recent study, investigators utilized dynamic contrast enhanced-perfusion imaging (DCE-PI) and ultrasonic molecular imaging (USMI) to gauge response to therapy for pancreatic cancer.

The research was published in the January 2013 issue journal Technology in Cancer Research and Treatment. Paul Dayton, PhD, University of North Carolina (UNC) Lineberger Comprehensive Cancer Center (Chapel Hill, USA), and senior author of the study, said, “What we found is that using two noninvasive technologies, we can detect response to therapy earlier than by relying on tumor volume changes. Having new noninvasive, inexpensive technologies available to measure response to therapy earlier during the course of treatment would be a significant advance in the ability to tailor a person’s treatment to improve outcomes.”

Dr. Dayton, a UNC associate professor of biomedical engineering, worked with Jen Jen Yeh, M.D, an associate professor of surgery and pharmacology, to assess the imaging technologies on human pancreatic cancer in a preclinical model. Both investigators are members of the Lineberger Comprehensive Cancer Center.

USMI has the ability to depict noninvasively the biologic processes at the cellular and molecular levels. It accomplishes this with the use of targeted contrast agents, which are markers that bind to specific proteins expressed on cancer cells within the body. These contrast agents enable a conventional ultrasound system to identify signals from cancer cells that would otherwise be undetectable.

Ultrasound DCE-PI is a technique used noninvasively to track the blood flow in the microcirculation. Because growing tumors require abnormally increased blood flow, alterations in blood vessel structure or density can provide data regarding tumor malignancy. The researchers employed a drug that suppresses a protein specific to tumors. They then used the imaging applications to gauge the response of two different tumors, one known to respond to the drug therapy, and a second known not to respond. The findings indicated that USMI was able to detect molecular signs of tumor response to therapy after only two days.

A change in blood flow in the tumor was seen to detect response after day 14 using DCE-PI. Over the same period, standard volume measurements were not able to detect therapeutic response, and prior studies suggested that volume measurements do not become indicative of response until approximately 28 days. Therefore, these modalities revealed a substantial improvement in the early identification of tumor response to therapy, using contrast enhanced ultrasound imaging.

The contrast agents for USMI currently in clinical trials in Europe for cancer imaging, however, they are not yet available in the United States.

Related Links:
University of North Carolina Lineberger Comprehensive Cancer Center

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63 (!!!!! 8421.1826324463): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (650.16746520996): SELECT fid FROM jos_deeppockets WHERE id=294745096 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294745096 AND published='1' LIMIT 1

65 (363.11149597168): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

66 (83.92333984375): select jos_twitters.link from jos_twitters where cat=10

67 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

68 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

69 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

70 (51.975250244141): SELECT fid FROM jos_deeppockets WHERE id=294745096 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294745096 AND published='1' LIMIT 1

71 (44.107437133789): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

72 (619.88830566406): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745096 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (449.89585876465): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745096 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (!!!!! 1724.0047454834): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (91.075897216797): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (56.982040405273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745096 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (37.908554077148): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745096 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (97.036361694336): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

107 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

108 (664.94941711426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745096 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (520.94459533691): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745096 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

111 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

112 (330.92498779297): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294745096 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (!!!!! 2177.0000457764): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294745096 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (599.86114501953): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (488.9965057373): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

117 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

118 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

119 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

120 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

121 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

122 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

123 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

124 (329.01763916016): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 47527.074813843): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (643.96858215332): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745096 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745096 AND type='deeppockets_item' AND published='1' LIMIT 1

127 (!!!!! 16274.929046631): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (66.995620727539): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (313.99726867676): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (270.12825012207): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (216.96090698242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (951.05171203613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (269.88983154297): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (160.93254089355): SELECT name FROM jos_deeppockets WHERE id=214

140 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=214

141 (530.95817565918): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (464.91622924805): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (!!!!! 2213.9549255371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

144 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

145 (!!!!! 14918.804168701): TRUNCATE TABLE jos_trademed_module

146 (!!!!! 1486.06300354): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745096 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (85.830688476562): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745096 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (458.95576477051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

151 (266.07513427734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

152 (!!!!! 3584.8617553711): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

154 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

155 (37.908554077148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745096 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745096 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (43.869018554688): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

157 (38.862228393555): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

158 (36.001205444336): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

160 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745096 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745096 AND published='1' LIMIT 1

161 (52.928924560547): select jos_twitters.link from jos_twitters where cat=10

162 (28.848648071289): select jos_facebook.link from jos_facebook where cat=10

163 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

164 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

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