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Ultrasound-Guided HIFU Used for the Treatment of Breast Fibroadenomas

By MedImaging International staff writers
Posted on 18 Dec 2012

Image: The EchoPulse HIFU system (Photo courtesy of Theraclion).

A new noninvasive therapeutic application using ultrasound-guided, high-intensity focused ultrasound (HIFU) is currently being employed for a specifically localized ablation with no skin damage. The ultrasound waves are focused on a small area where the rise in temperature leads to tissue necrosis. This precision avoids injuring healthy tissues around the lesion. The echotherapy is a technique that enables clinicians to visualize and simultaneously treat a tumor such as fibroadenoma with no incision or scar.

Theraclion (Paris, France), a specialist in cutting-edge medical technology that develops echotherapy technology that uses HIFU, has received the CE marking approval for the noninvasive treatment of breast fibroadenomas, a first for this indication.

“The CE marking widens the use of our technology in the major area of breast fibroadenoma. Our technology can now be offered to all women suffering from this pathology in Europe. They can benefit from a noninvasive outpatient treatment without general anesthesia which puts an end to the embarrassment and anxiety triggered by this kind of tumor. Noninvasive focused ultrasound surgery guided by real-time ultrasound imaging is consistent with the logic of developing lesser invasive treatments and a reduction of health costs. This market authorization in Europe will allow us to grow by creating noninvasive surgery centers based on our resulting echotherapy solution within leading hospitals and clinics. Other tumors beside breast fibroadenomas will be treated in a noninvasive manner in the near future,” said Jean-Yves Burel, CEO of Theraclion.

Fibroadenoma is the most widely spread breast benign tumor, with 10% of women risk developing it in their lifetime. It represents more than half of breast biopsies. This disorder hits women of all ages but is a lot more frequent with women under 30. Estimates show that 50,000 fibroadenoma tumors are detected each year in France, with 320,000 in Europe and 640,000 in the United States.

“I used the EchoPulse to treat 11 patients during a clinical trial at the American Hospital of Paris from January to October 2012. The results from this technique are encouraging with a 60% volume reduction of fibroadenoma in an average period of six months. EchoPulse could represent an interesting alternative to classical surgery,” added Dr. Marc Abehsera from the medical imaging service at the American Hospital of Paris.

“It is interesting [to be able to] participate in the assessment of echotherapy in breast fibroadenoma in the French trial. We are hoping to participate in a multicenter trial that will measure the effects of this type of treatment in breast cancer,” stated Dr. Edouard Poncelet from the woman imaging service at the Valenciennes Hospital Center).

A clinical trial on 40 patients has shown the efficiency and the excellent tolerance of echotherapy for this type of pathology. Currently, 48 fibroadenomas have been treated in three French centers (Lille Jeanne de Flandres Hospital, the Valenciennes Hospital, and the American Hospital of Paris) and one center in Bulgaria (the University Hospital of Sofia), with considerable volume reductions accompanied by the resolution of symptoms.

EchoPulse, the medical device developed by Theraclion, uses ultrasound imaging as a targeting system and HIFU for tissue necrosis, thereby eliminating the need for patients to undergo a surgical procedure. EchoPulse is unique as it combines in the same device an imaging monitoring and treatment system while remaining compact and mobile. In addition to its ergonomic benefits, it provides excellent image quality, a millimetric accuracy of wave shots, and an integrated cooling system for the patient’s safety. The benefits offered by EchoPulse are beneficial for the patients (noninvasive, scarless, and mobile treatment, conscious sedation) but also for the practitioners (fast, effective, and harmless) and hospital centers (efficient, less hospitalization costs, one device for several pathologies).

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57 (!!!!! 3449.2015838623): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

58 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

59 (!!!!! 2284.049987793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

60 (200.98686218262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

61 (!!!!! 7145.1663970947): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 1008.9874267578): SELECT fid FROM jos_deeppockets WHERE id=294743867 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294743867 AND published='1' LIMIT 1

63 (333.07075500488): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (!!!!! 1282.9303741455): select jos_twitters.link from jos_twitters where cat=10

65 (665.90309143066): select jos_facebook.link from jos_facebook where cat=10

66 (399.11270141602): select jos_google_plus.link from jos_google_plus where cat=10

67 (46.014785766602): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 2501.9645690918): SELECT fid FROM jos_deeppockets WHERE id=294743867 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294743867 AND published='1' LIMIT 1

69 (187.87384033203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (987.05291748047): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294743867 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (654.93583679199): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294743867 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1478.910446167): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1498.9376068115): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (337.12387084961): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (265.12145996094): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (273.9429473877): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (!!!!! 2328.8726806641): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 3762.0067596436): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (518.798828125): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (349.99847412109): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (219.10667419434): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (257.01522827148): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (283.00285339355): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (836.84921264648): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294743867 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (186.92016601562): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294743867 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (199.0795135498): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 2375.1258850098): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 1045.9423065186): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 1214.0274047852): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 2119.0643310547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

105 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

106 (!!!!! 1915.9317016602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294743867 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 1338.005065918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294743867 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 3576.9939422607): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

109 (!!!!! 1910.924911499): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

110 (397.92060852051): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294743867 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 2619.9817657471): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294743867 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (821.82884216309): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (527.85873413086): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (157.83309936523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

115 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

116 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

117 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

118 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

119 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

120 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

121 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

122 (366.2109375): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 226536.03553772): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 7722.1393585205): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294743867 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294743867 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 5698.9192962646): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 1670.1221466064): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 4359.0068817139): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (627.04086303711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 1009.9411010742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (272.03559875488): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (876.90353393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (546.93222045898): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (!!!!! 4162.073135376): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (772.95303344727): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 2017.9748535156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 1127.9582977295): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (598.19221496582): SELECT name FROM jos_deeppockets WHERE id=214

138 (51.975250244141): SELECT name FROM jos_deeppockets WHERE id=214

139 (!!!!! 1441.9555664062): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1037.1208190918): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1189.9471282959): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

142 (!!!!! 4410.0284576416): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

143 (!!!!! 11319.875717163): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 4875.8983612061): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294743867 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 1065.9694671631): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294743867 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (764.84680175781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 1729.9652099609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (968.93310546875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

149 (847.10121154785): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

150 (!!!!! 9190.0825500488): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 3206.0146331787): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

152 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

153 (!!!!! 3428.9360046387): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294743867 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294743867 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (62.942504882812): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (51.975250244141): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (961.0652923584): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

158 (85.830688476562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294743867 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294743867 AND published='1' LIMIT 1

159 (74.863433837891): select jos_twitters.link from jos_twitters where cat=10

160 (39.100646972656): select jos_facebook.link from jos_facebook where cat=10

161 (39.100646972656): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

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