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Twinkling-Artifact Ultrasound Detects, Treats Kidney Stones

By MedImaging International staff writers
Posted on 14 Feb 2012

Space scientists are developing an ultrasound technology that could resolve various healthcare challenges associated with kidney stone treatment. The new technology detects stones with sophisticated ultrasound imaging based on a process called twinkling artifact, and provides treatment by pushing the stone with focused ultrasound. This technology could not only be beneficial for healthcare in space, but could also transform the treatment of kidney stones on Earth.

Kidney stones are frequently painful and sometimes difficult to remove, and 10% of the population will suffer from them. In space, the risk of developing kidney stones is exacerbated due to environmental conditions. The health risk is magnified by the fact that resource limitations and distance from Earth could restrict treatment options.

The project is led by US National Space Biomedical Research Institute (NSBRI; Houston, TX, USA) smart medical systems and technology team lead investigator Dr. Lawrence Crum and coinvestigator Dr. Michael Bailey; both are researchers at the Applied Physics Laboratory at the University of Washington (APL-UW; Seattle, USA).

Dr. Bailey stated that their technology is based on equipment currently available. “We have a diagnostic ultrasound machine that has enhanced capability to image kidney stones in the body,” said Dr. Bailey, a lead engineer at APL-UW. “We also have a capability that uses ultrasound waves coming right through the skin to push small stones or pieces of stones toward the exit of the kidney, so they will naturally pass, avoiding surgery.”

On Earth, the current preferred removal method is for patients to drink water to force the stones to pass naturally, but this does not always work, and surgery is frequently the only option. In space, the threat from kidney stones is greater due to the difficulty of keeping astronauts fully hydrated. Another factor is that bones demineralize in the reduced-gravity environment of space, dumping salts into the blood and eventually into the urine. The increased concentration of salts in the urine is a risk factor for stones.

Dr. Crum, who is a lead physicist at APL-UW, reported that kidney stones could be a serious difficulty on a long-duration mission. “It is possible that if a human were in a space exploration environment and could not easily return to Earth, such as a mission to an asteroid or Mars, kidney stones could be a dangerous situation,” Dr. Crum said. “We want to prepare for this risk by having a readily available treatment, such as pushing the stone via ultrasound.”

Before a stone can be pushed, it needs to be located. Conventional ultrasound units have a black and white imaging mode called B-mode that creates an image of the anatomy. They also have a Doppler mode that specifically displays blood flow and the motion of the blood within tissue in color. In Doppler mode, a kidney stone can appear brightly colored and twinkling. The reason for this is not known; however, the scientists are working to understand what causes the twinkling artifact image.

“At the same time, we have gone beyond twinkling artifact and utilized what we know with some other knowledge about kidney stones to create specific modes for kidney stones,” Dr. Bailey said. “We present the stone in a way that looks like it is twinkling in an image in which the anatomy is black and white, with one brightly colored stone or multiple colored stones.”

Once the stones are located, the ultrasound machine operator can select a stone to target, and then, with a simple push of a button, send a focused ultrasound wave, approximately half a millimeter in width, to move the stone toward the kidney’s exit. The stone moves about 1 cm per second. In addition to being an option to surgery, the technology can be used to “clean up” after surgery. “There are always residual fragments left behind after surgery,” Dr. Bailey said. “Fifty percent of those patients will be back within five years for treatment. We can help those fragments pass.”

The ultrasound technology being developed for NSBRI by Drs. Crum and Bailey is not restricted to kidney stone detection and removal. The technology can also be used to stop internal bleeding and ablate tumors. Dr. Crum reported that the research group has novel plans for the technology. “We envision a platform technology that has open architecture, is software-based and can use ultrasound for a variety of applications,” he said. “Not just for diagnosis, but also for therapy.”

NSBRI’s research range includes other projects seeking to develop smart medical systems and technologies, such as new uses for ultrasound that provide healthcare to astronauts in space. Dr. Crum, who served eight years as an NSBRI team leader, noted that the innovative approaches to overcome the restrictive environment of space could make an impact on Earth.

“Space has demanded medical care technology that is versatile, low-cost, and has restricted size. All of these required specifications for use in a space environment are now almost demanded by the general public,” Dr. Crum said. “One of the reasons that translation from one site to another is possible is because of NSBRI’s investment.”

Related Links:
US National Space Biomedical Research Institute
Applied Physics Laboratory at the University of Washington

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56 (!!!!! 21042.823791504): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739281 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1962.9001617432): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

58 (330.92498779297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

59 (!!!!! 4295.1107025146): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

60 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

61 (!!!!! 2175.0926971436): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 1196.8612670898): SELECT fid FROM jos_deeppockets WHERE id=294739281 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294739281 AND published='1' LIMIT 1

63 (372.88665771484): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (215.05355834961): select jos_twitters.link from jos_twitters where cat=10

65 (415.08674621582): select jos_facebook.link from jos_facebook where cat=10

66 (52.928924560547): select jos_google_plus.link from jos_google_plus where cat=10

67 (!!!!! 1106.0237884521): select jos_linkedin.link from jos_linkedin where cat=10

68 (188.11225891113): SELECT fid FROM jos_deeppockets WHERE id=294739281 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294739281 AND published='1' LIMIT 1

69 (423.90823364258): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (370.97930908203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739281 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (219.10667419434): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739281 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (205.99365234375): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 7387.8765106201): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (!!!!! 5682.9452514648): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (!!!!! 10061.979293823): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (!!!!! 8878.9463043213): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (!!!!! 4058.1226348877): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (!!!!! 6944.8947906494): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 7872.8199005127): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (!!!!! 7993.9365386963): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (!!!!! 7869.0052032471): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (!!!!! 7252.9315948486): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 5106.2107086182): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (!!!!! 1039.981842041): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (619.17304992676): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (849.00856018066): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739281 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (52.928924560547): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739281 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (221.01402282715): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (482.79762268066): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (232.93495178223): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (221.01402282715): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (220.06034851074): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (262.97569274902): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (241.99485778809): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (!!!!! 1072.883605957): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (319.00405883789): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (710.96420288086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

105 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

106 (!!!!! 1492.0234680176): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739281 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (714.06364440918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739281 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 7032.1559906006): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

109 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

110 (278.94973754883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294739281 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (851.86958312988): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294739281 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1212.1200561523): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (735.99815368652): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (699.04327392578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

115 (381.9465637207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

116 (482.08236694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

117 (254.15420532227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

118 (455.85632324219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

119 (75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

120 (364.06517028809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

121 (224.11346435547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

122 (453.94897460938): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 43544.054031372): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 3226.9954681396): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739281 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739281 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (52.928924560547): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (36.001205444336): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (205.99365234375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (211.00044250488): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (133.03756713867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (142.09747314453): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (163.07830810547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (674.00932312012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (375.03242492676): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (312.08992004395): SELECT name FROM jos_deeppockets WHERE id=214

138 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=214

139 (661.13471984863): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (633.00132751465): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (282.04917907715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

142 (226.97448730469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

143 (!!!!! 18069.982528687): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 11052.846908569): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739281 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (246.04797363281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739281 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1245.9754943848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (890.97023010254): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

149 (109.91096496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

150 (!!!!! 2310.037612915): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (850.91590881348): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

152 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

153 (68.902969360352): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739281 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739281 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (814.91470336914): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (56.982040405273): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (291.82434082031): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (488.9965057373): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

158 (201.94053649902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739281 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739281 AND published='1' LIMIT 1

159 (!!!!! 5162.0006561279): select jos_twitters.link from jos_twitters where cat=10

160 (56.028366088867): select jos_facebook.link from jos_facebook where cat=10

161 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

162 (618.93463134766): select jos_linkedin.link from jos_linkedin where cat=10

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