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MR-Guided, Focused Ultrasound Treatment Stops Essential Tremors

By MedImaging International staff writers
Posted on 24 Mar 2011

Magnetic resonance (MR)-guided focused ultrasound was used to successfully treat a patient with essential tremor (ET), a progressive neurologic disorder that affects millions of people worldwide and causes involuntary shaking of the hands, head, face, eyelids, voice, or other muscles.

The procedure has been life changing for the patient, according to W. Jeffrey Elias, MD, a neurosurgeon from the University of Virginia (UVA; Charlottesville, USA) and a leading authority on the treatment of movement disorders. "He had been unable to use his dominant right hand for over a decade because it shook uncontrollably. When we completed the treatment, his tremor was gone. In the recovery room, he used his right hand to drink from a cup without spilling, and he even worked on a crossword puzzle."

Performed on February 25, 2011, the treatment marked the start of a first in the world clinical trial being funded by the Focused Ultrasound Surgery Foundation. The single-arm, nonrandomized pilot study is being conducted at UVA and is expected to treat as many as 15 patients with ET under a US Food and Drug Administration (FDA)-approved protocol. Dr. Elias is the lead investigator.

During the MR-guided focused ultrasound procedure, pulses of focused ultrasound waves were directed through the patient's scalp and skull to a precisely targeted spot in the thalamus--a region deep within the brain known to be an effective target for treating ET and other movement disorders. The patient received no anesthesia for the treatment and was able to provide feedback to Dr. Elias and his team after each sonication. Following the treatment, he walked out of the focused ultrasound suite reporting that the ultrasound treatments were painless.

Per study protocol, the patient remained in the hospital overnight and returned home the next day. A follow-up visit a week later indicated that his right hand was functioning normally. Additional follow-up evaluations will occur 30 and 90 days post treatment, and Dr. Elias is hopeful that the patient's tremor will not return. While excited about the remarkable outcome this first treatment, Dr. Elias cautioned that it is only the initial step in a lengthy process. "We need to complete this study and other clinical trials successfully before this treatment is eligible for approval by the FDA and its counterparts in other countries," he noted.

Chairman of the Focused Ultrasound Surgery Foundation (Charlottesville, VA, USA), Neal Kassell, MD, noted that the success of this study could lead to other new treatments. "By demonstrating that MR-guided focused ultrasound can safely and effectively treat tissue deep in the brain with great precision and accuracy, we will open the door for treating a variety of conditions such as Parkinson's disease, brain tumors, and epilepsy. Much work remains to be done, but the path is clear. Because the brain poses more complex technical challenges than other organs, success in treating ET could advance the entire field of MR-guided focused ultrasound. This study will undoubtedly inspire researchers who are developing new focused ultrasound therapies for the liver, breast and prostate, which are less complicated to treat."

To further clinical research for ET, the Foundation is funding a second pilot study at Sunnybrook Health Sciences Center (Toronto, Canada). That clinical trial is scheduled to begin later in 2011 under a Health Canada-approved protocol.

Current treatment options for ET range from medication to surgery. In the United States, medication therapy provides satisfactory symptom control for many of the 10 million people with ET. For patients who do not respond to medication, the surgical procedures of choice are stereotactic thalamotomy or deep brain stimulation of the ventralis intermedius nucleus of the thalamus.

The UVA study is the first step in determining if MR-guided focused ultrasound is a safe and effective treatment for ET and if it offers benefits beyond current surgical options. The study is enrolling patients who are 18 to 80 years old and have completed trials of at least two ET tremor medications without success. Before and three months after treatment, participating patients are being evaluated for general health, neurologic status, and tremor measurements. The study is also collecting information about any device/procedure-related side effects that occur during the follow-up period.

During treatment, patients remain awake and do not receive anesthesia. They are positioned on the ExAblate Neuro, a system manufactured by InSightec, Ltd. (Haifa, Israel) that has a customized table with a helmet-like head unit containing phased array focused ultrasound transducers. The table is placed inside a high-resolution MR scanner that provides imaging for precise targeting. The scanner also provides thermal feedback to confirm and control sonication temperatures. Treatments are completely noninvasive and do not involve ionizing radiation.

All study treatments are being performed at the UVA Focused Ultrasound Center, which was established under a partnership of UVA, the Commonwealth of Virginia, InSightec, and the Focused Ultrasound Surgery Foundation.

Related Links:
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56 (472.06878662109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1414.0605926514): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

58 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

59 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

60 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

61 (89.883804321289): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (470.87669372559): SELECT fid FROM jos_deeppockets WHERE id=294734036 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294734036 AND published='1' LIMIT 1

63 (305.8910369873): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (66.041946411133): select jos_twitters.link from jos_twitters where cat=10

65 (56.028366088867): select jos_facebook.link from jos_facebook where cat=10

66 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

68 (32.901763916016): SELECT fid FROM jos_deeppockets WHERE id=294734036 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294734036 AND published='1' LIMIT 1

69 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (297.06954956055): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (334.9781036377): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (84.161758422852): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (69.856643676758): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.994415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (33.140182495117): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (54.836273193359): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

105 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

106 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

109 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

110 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (494.00329589844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (532.15026855469): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (336.88545227051): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

115 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

116 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

117 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

118 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

119 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

120 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

121 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

122 (315.18936157227): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 55321.931838989): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1774.0726470947): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734036 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734036 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 19312.858581543): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 1027.1072387695): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (324.96452331543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (471.11511230469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (324.96452331543): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (201.94053649902): SELECT name FROM jos_deeppockets WHERE id=214

138 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=214

139 (610.8283996582): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (478.98292541504): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

142 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

143 (!!!!! 8358.9553833008): TRUNCATE TABLE jos_trademed_module

144 (93.936920166016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734036 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (787.01972961426): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

149 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

150 (!!!!! 1413.106918335): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

152 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

153 (44.822692871094): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734036 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734036 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (34.093856811523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (43.869018554688): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (189.06593322754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

158 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734036 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734036 AND published='1' LIMIT 1

159 (43.153762817383): select jos_twitters.link from jos_twitters where cat=10

160 (45.061111450195): select jos_facebook.link from jos_facebook where cat=10

161 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

162 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

163 (442.9817199707): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

164 (!!!!! 1048.0880737305): insert into jos_banners_delta values (14202,'2025-06-27 12:47:58','216.73.216.249','view'),(14203,'2025-06-27 12:47:58','216.73.216.249','view')

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