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U.S. Health System Center Opening World's First Fully Dedicated Focused-Ultrasound Facility

By MedImaging International staff writers
Posted on 21 Sep 2009

A new health center is launching a multidisciplinary research program to investigate the safety and effectiveness of magnetic resonance (MR)-guided focused ultrasound (MRgFUS) in treating brain, breast, prostate, bone and liver tumors, and disorders such as epilepsy, stroke, chronic pain, Parkinson's disease, and essential tremor.

The University of Virginia (UVA) Health System (Charlottesville, VA, USA) held a scientific symposium and dedication ceremony on September 14, 2009 to mark the opening of its new MRgFUS Surgery Center, the first facility in the world that will be used exclusively for performing research and providing treatments with one of today's most promising noninvasive medical technologies.

Beginning in October 2009, the Center, located on the grounds of the UVA Health System, will also offer U.S. Food and Drug Administration (FDA)-approved MRgFUS treatments to women with small, benign tumors known as uterine fibroids. Clinical offerings will expand as focused ultrasound treatments for other conditions are developed and receive FDA-approval. "The opening of this facility is an exciting development," commented James M. Larner, M.D., chairman of UVA's department of radiation oncology, and director of the new center. "Our facility is the first to have a fully-dedicated magnet, meaning it will be used exclusively for MRgFUS research and treatments. Full-time access to equipment should accelerate the pace of our research and place UVA at the forefront of this emerging area of healthcare."

UVA specialists in anesthesiology, biomedical engineering, gynecology, neurology, neurosurgery, oncology, radiology, radiation oncology surgery, and urology will conduct research at the center. Alan H. Matsumoto, M.D., interim chairman, department of radiology and codirector of the new center, will provide focused ultrasound treatments to patients with uterine fibroids. "This therapy will add an important option to the spectrum of treatments we offer for uterine fibroids. For some women, this noninvasive procedure will be the ideal choice," he noted.

MRgFUS procedures are performed on an outpatient basis without general anesthesia and cause minimal discomfort and few complications, allowing patients to recover rapidly. Hailed as a breakthrough technology, MRgFUS integrates the visualization capabilities of MRI with the intense energy that is created when multiple waves of high frequency ultrasound are directed to a treatment site. Highly precise, MRgFUS can target treatment sites as small as one millimeter in diameter.

Single waves of focused ultrasound are as harmless to body tissue as those emitted during diagnostic ultrasound testing. However, when waves intersect--which is what happens during focused ultrasound treatments--they become powerful enough to destroy tumors and liquefy blood clots.

Targeted drug delivery is another promising use of focused ultrasound. In such procedures, patients receive injections of chemotherapy or other drugs, which remain inactive while the bloodstream carries them to the treatment site. When the drugs reach the targeted tumor or tissue, clinicians activate them using waves of MRgFUS energy. Such precise and localized drug delivery is expected to eliminate the side effects of chemotherapy and other powerful pharmaceuticals.

Currently, MRgFUS has one FDA-approved application--the treatment of uterine fibroids--and more uses are anticipated. Clinical trials in several countries are now evaluating focused ultrasound's effectiveness in treating metastatic bone tumors, breast and brain cancer, and other malignancies.

Neal F. Kassell, M.D., professor of neurosurgery at UVA, has been a key force behind the opening of the new MRgFUS Surgery Center. "Focused ultrasound may be the most important therapeutic advancement since the scalpel and could affect millions of people around the globe," he said.

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58 (!!!!! 11585.95085144): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

59 (!!!!! 2923.0117797852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

60 (!!!!! 7838.9644622803): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

61 (!!!!! 7002.1152496338): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 5846.0235595703): SELECT fid FROM jos_deeppockets WHERE id=294725477 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294725477 AND published='1' LIMIT 1

63 (843.04809570312): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

64 (751.97219848633): select jos_twitters.link from jos_twitters where cat=10

65 (253.91578674316): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 2582.0732116699): select jos_google_plus.link from jos_google_plus where cat=10

67 (416.04042053223): select jos_linkedin.link from jos_linkedin where cat=10

68 (313.99726867676): SELECT fid FROM jos_deeppockets WHERE id=294725477 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294725477 AND published='1' LIMIT 1

69 (56.028366088867): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (!!!!! 3114.9387359619): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725477 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 1003.9806365967): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725477 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 2630.9490203857): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (801.08642578125): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (257.01522827148): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (694.99015808105): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 2502.9182434082): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725477 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (100.13580322266): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725477 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (71.048736572266): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 7396.936416626): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (!!!!! 8251.1901855469): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 4585.0276947021): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (557.89947509766): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 2213.9549255371): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (545.02487182617): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (351.90582275391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (851.86958312988): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (483.03604125977): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (424.86190795898): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (339.03121948242): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (346.18377685547): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 2238.9888763428): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

105 (922.20306396484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

106 (577.21138000488): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725477 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 1481.0562133789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725477 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 3411.0546112061): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

109 (777.00614929199): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

110 (530.00450134277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725477 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1136.0645294189): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725477 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (842.09442138672): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 1001.8348693848): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (710.96420288086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

115 (392.91381835938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

116 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

117 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

118 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

119 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

120 (782.96661376953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

121 (389.81437683105): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

122 (!!!!! 1707.0770263672): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 103538.99002075): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1704.9312591553): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725477 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725477 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 66300.868988037): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (674.96299743652): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (967.02575683594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (!!!!! 5779.0279388428): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (530.95817565918): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (429.15344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (!!!!! 2875.0896453857): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (!!!!! 5906.8202972412): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (263.92936706543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (!!!!! 2130.9852600098): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (497.10273742676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (331.16340637207): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (889.06288146973): SELECT name FROM jos_deeppockets WHERE id=214

138 (!!!!! 1399.9938964844): SELECT name FROM jos_deeppockets WHERE id=214

139 (!!!!! 1484.8709106445): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 2243.0419921875): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 3887.8917694092): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

142 (!!!!! 1507.043838501): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

143 (!!!!! 12380.123138428): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 2850.7709503174): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725477 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (562.19100952148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725477 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (591.99333190918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 2485.0368499756): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 2486.9441986084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

149 (!!!!! 1882.0762634277): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

150 (!!!!! 2872.9438781738): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 6329.0596008301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

152 (!!!!! 5486.9651794434): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

153 (!!!!! 2024.8889923096): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725477 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725477 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (!!!!! 4212.8562927246): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (493.04962158203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

156 (98.943710327148): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 12960.910797119): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

158 (!!!!! 5728.006362915): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725477 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725477 AND published='1' LIMIT 1

159 (560.99891662598): select jos_twitters.link from jos_twitters where cat=10

160 (37.193298339844): select jos_facebook.link from jos_facebook where cat=10

161 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

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