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MRI and Ultrasound Application Developed to Recognize Malignant Tumors Before they Metastasize

By MedImaging International staff writers
Posted on 16 Feb 2009

A new imaging approach--based on a combination of magnetic resonance imaging (MRI) and ultrasound technology--is able to measure the metabolic rates of breast cancer cells. This approach helps determine at an earlier stage than ever before which cells are metastasizing, and how they should be treated.

Not all breast cancers are similar, and not all will have deadly consequences. But because clinicians find it difficult to effectively determine which tumors will metastasize, many patients do not receive the therapy that fits their disease. Researchers from Tel Aviv University (TAU; Israel) have now refined breast cancer identification so that each course of treatment is as individual as the woman being treated.

The method, expected to start clinical trials in 2010, is currently being researched in Israel hospitals. "We have developed a nonintrusive way of studying the metabolism of breast cancer in real time,” remarked Dr. Ilan Tsarfaty, a lead researcher from TAU's Sackler Faculty of Medicine. "It's an invaluable tool. By the time results are in from a traditional biopsy, the cancer can already be radically different. But using our technique, we can map the tumor and its borders and determine with high levels of certainty--right away--which patients should be treated aggressively.”

The research falls in a new field called "translational and personalized medicine,” and according to Dr. Tsarfaty, it has the potential to save thousands of lives. Articles describing his methodologies are slated for upcoming publication in the journals Cancer Research and Neoplasia. "Current breast cancer treatments are not tailored to individual patients,” Dr. Tsarfaty said. "Our approach to profiling individual tumors will not only help save lives today, it will provide the basic research for developing cancer drugs of the future.”

The new research can be applied to all solid tumors, including those resulting from lung and brain cancer, and could be used to respond to a wide range of neurodegenerative diseases, such as Alzheimer's, Dr. Tsarfaty reported.

Dr. Tsarfaty's MRI and ultrasound-imaging application tracks the metabolic changes that occur during cancer metastasis. Increased blood flow (which can be sensed by ultrasound) and an increase of oxygen consumption (measured with an MRI) can indicate cancer metastasis with unprecedented levels of sensitivity.

Typically, scientists look for structural alterations in the body, such as the presence of a tumor. But with their new methods, Dr. Tsarfaty and his team, which includes his wife, a radiologist, are actually able to "see” cancer metastasis within a small group of cells long before the cancer spreads to other organs in the body. "Today, clinicians only diagnose cancer when they see a tumor several millimeters in size. But our diagnosis can be derived from observing only a few cells, and looks specifically at the activation levels of a protein called Met. Activated Met is an oncogen,” Dr. Galia Tsarfaty stated. "If the tumor cells show activation of Met, we can design personalized medicine to treat a specific kind of breast cancer.”

At Tel Aviv University, Dr. Tsarfaty is now working to establish a molecular imaging center--one of the first to encompass a multi-discipline approach to cancer imaging and treatment.

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62 (!!!!! 1749.9923706055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

63 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

64 (233.88862609863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

65 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

66 (143.05114746094): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

67 (766.99256896973): SELECT fid FROM jos_deeppockets WHERE id=294722070 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294722070 AND published='1' LIMIT 1

68 (72.956085205078): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

69 (81.062316894531): select jos_twitters.link from jos_twitters where cat=10

70 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

71 (72.002410888672): select jos_google_plus.link from jos_google_plus where cat=10

72 (43.153762817383): select jos_linkedin.link from jos_linkedin where cat=10

73 (84.161758422852): SELECT fid FROM jos_deeppockets WHERE id=294722070 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294722070 AND published='1' LIMIT 1

74 (51.975250244141): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

75 (602.00691223145): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294722070 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (434.87548828125): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294722070 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

77 (65.088272094727): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

78 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (70.095062255859): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (85.115432739258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294722070 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (46.014785766602): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294722070 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

94 (52.928924560547): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

95 (101.80473327637): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (78.201293945312): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

110 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

111 (99.897384643555): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294722070 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294722070 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (121.11663818359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

114 (259.8762512207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

115 (621.08039855957): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294722070 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (624.8950958252): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294722070 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (89.883804321289): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294722069 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

118 (538.11073303223): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294722069 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

119 (859.97581481934): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

120 (687.1223449707): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

121 (147.81951904297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

122 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

123 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

124 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

125 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

126 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

127 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

128 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

129 (420.09353637695): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

130 (!!!!! 21233.081817627): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

131 (489.95018005371): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294722070 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294722070 AND type='deeppockets_item' AND published='1' LIMIT 1

132 (!!!!! 8496.0460662842): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

133 (128.98445129395): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

134 (54.121017456055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

135 (31.232833862305): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

136 (87.976455688477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

137 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

138 (337.83912658691): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

139 (77.962875366211): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

140 (57.93571472168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

141 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

142 (620.12672424316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

143 (708.10317993164): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

144 (52.928924560547): SELECT name FROM jos_deeppockets WHERE id=214

145 (42.915344238281): SELECT name FROM jos_deeppockets WHERE id=214

146 (666.14151000977): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

147 (560.04524230957): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

148 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

149 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

150 (!!!!! 12035.131454468): TRUNCATE TABLE jos_trademed_module

151 (144.00482177734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294722070 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

152 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294722070 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

153 (609.8747253418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

154 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

155 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

156 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

157 (!!!!! 1685.1425170898): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

158 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

159 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

160 (56.982040405273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294722070 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294722070 AND type='deeppockets_item' AND published='1' LIMIT 1

161 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

162 (48.87580871582): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

163 (74.863433837891): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

164 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

165 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294722070 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294722070 AND published='1' LIMIT 1

166 (53.882598876953): select jos_twitters.link from jos_twitters where cat=10

167 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

168 (44.107437133789): select jos_google_plus.link from jos_google_plus where cat=10

169 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

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