We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




Sensitive Ultrasound Technology Detects Early-Stage Cancer

By MedImaging International staff writers
Posted on 17 Nov 2008
European researchers have developed highly sensitive ultrasound equipment that can detect tiny quantities of reflective microbubbles engineered to stick to specific tumor cells. The technique should identify tumors early and improve patients' chances of survival.

Most of the current diagnostic techniques--biopsy analysis, biochemical tests, and medical imaging--are not sufficiently sensitive. These frequently return a false-negative result, and the tumor is only discovered when it is much larger, and too late.

European researchers are developing a new method that will help clinicians visualize tiny quantities of diseased tissue in patients. The technology could detect tumors in their very earliest stages of development and help clinicians begin treatments much earlier, giving patients a much better chance of survival. The new approach uses medical ultrasound. A probe sends high-frequency acoustic waves into the body and detects how they bounce off the interfaces between different tissues.

To improve the sensitivity of this imaging technique, a sonographer may sometimes inject a contrast agent into patients, which greatly increases the scattering of the acoustic waves back to the probe. For ultrasound imaging, contrast agents are based on ‘microbubbles,' micron-sized gas-filled balls that show up brightly on the ultrasound image.

Researchers involved with the European Union- (EU)-funded TAMIRUT Project have developed a microbubble medium that can specifically target and bind to specific pathogenic cells in the body (such as endothelial cells of vessels lining the tumors). Combined with enhanced ultrasound equipment and signal processing capabilities, the system can detect where microbubbles adhere to target cells, and reveal the presence of early-stage tumors.

Working with the pharmaceutical company Bracco Research SA (Geneva, Switzerland), TAMIRUT researchers have developed a way to attach antibodies onto the surface of microbubbles. By selecting an antibody with an affinity for marker molecules found only on target vascular cells, the microbubbles adhere only to the target cells.

However, it is not easy to capture these hotspots on a scan. "We are looking at the very earliest stages of tumor growth, so there are not many cells present expressing the marker of interest,” explained Dr. Alessandro Nencioni, who coordinated the project. "There may be only three or four microbubbles adhered to a site and current ultrasound equipment is not able to pick these up. Work on the hardware and signal processing is an essential aspect of this project as we seek to develop next-generation ultrasound imaging capabilities.”

Esaote (Genoa, Italy), a manufacturer of medical imaging equipment, is working with several research partners and two SMEs (small and medium enterprises): Vermon (Tours, France), a manufacturer of medical imaging probes, and SignalGeneriX (Limassol, Cyprus), a small firm with expertise in signal processing. Their aim is to produce a scanner and a dedicated probe that can transmit and receive ultrasound waves across a wide range of frequencies and waveforms to exploit (without any modification) the harmonic components caused by nonlinear scattering of the acoustic wave of the microbubbles.

The scanning equipment must have sufficient processing power to interpret the waves picked up by the probe, update the live image and adjust the transmitted waveforms in real time. Their detecting function is ensured by a specifically developed signal processing methods, able to detect a very limited number of microbubbles (down to a single bubble), to estimate their concentration, and to track their behavior to get the diagnostic answer.

Originally, the project partners thought it would be possible to differentiate between bound and unbound microbubbles by the way they scatter particular ultrasound frequencies and wave forms. However, extensive simulations and laboratory testing have shown that this turns out to be very difficult. Instead, the scientists found a very simple answer: after 10 minutes, the microbubbles that are attached to target cells remain in place while the free microbubbles diffuse away.

The new probe should be able to detect and calculate their local concentration and operators will be able to visualize any areas of high microbubble density within an entire organ. The repetition of this new imaging technique over time could help medical staff to assess the evolution of a tumor, especially its vascularization. Using the engineered, targeted microbubble contrast agent, the improved ultrasound hardware and the signal processing, the TAMIRUT team has already demonstrated in simulations the potential of this approach for the early detection of prostate cancer.

This ultrasound method improves accuracy, patient comfort, and costs approximately half that of a biopsy. It could save European healthcare providers up to €250 million each year in biopsy costs alone.

The need for clinical trials of the targeted contrast agent and subsequent approval in humans means that the targeted microbubble agent is unlikely to be available for at least three years. However, the improved signal processing algorithms will help to increase the sensitivity of ultrasound equipment, irrespective of the use of these microbubbles.

Esaote is working with the other commercial partners to incorporate the new signal processing features into its medical imaging equipment.

Related Links:
TAMIRUT Project
Bracco Research
Esaote
Vermon
SignalGeneriX


Gold Member
Ultrasound System
FUTUS LE
Gold Member
Electrode Solution and Skin Prep
Signaspray
Bladder Scanner
PBSV3.2
PACS Workstation
PaxeraView PRO

Channels

MRI

view channel
Image: An AI tool has shown tremendous promise for predicting relapse of pediatric brain cancer (Photo courtesy of 123RF)

AI Tool Predicts Relapse of Pediatric Brain Cancer from Brain MRI Scans

Many pediatric gliomas are treatable with surgery alone, but relapses can be catastrophic. Predicting which patients are at risk for recurrence remains challenging, leading to frequent follow-ups with... Read more

Nuclear Medicine

view channel
Image: In vivo imaging of U-87 MG xenograft model with varying mass doses of 89Zr-labeled KLG-3 or isotype control (Photo courtesy of L Gajecki et al.; doi.org/10.2967/jnumed.124.268762)

Novel Radiolabeled Antibody Improves Diagnosis and Treatment of Solid Tumors

Interleukin-13 receptor α-2 (IL13Rα2) is a cell surface receptor commonly found in solid tumors such as glioblastoma, melanoma, and breast cancer. It is minimally expressed in normal tissues, making it... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.
162 queries executed
1
(!!!!! 7612.943649292): SET sql_mode = 'MYSQL40'
2 (230.07392883301): SELECT folder, element, published, params FROM jos_mambots WHERE published >= 1 AND access <= 0 AND folder = 'system' ORDER BY ordering
3 (566.95938110352): SELECT template FROM jos_templates_menu WHERE client_id = 0 AND ( menuid = 0 OR menuid = 294721086 ) ORDER BY menuid DESC LIMIT 1
4 (347.13745117188): DELETE FROM jos_session WHERE time < 1755342945 AND guest = 1 AND userid = 0
5 (71.048736572266): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
6 (114.91775512695): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
7 (48.87580871582): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
8 (!!!!! 2791.8815612793): SELECT * FROM jos_menu WHERE id = 294721086
9 (!!!!! 1116.9910430908): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
10 (!!!!! 2171.0395812988): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
11 (144.00482177734): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
12 (!!!!! 1474.142074585): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294721086) AND (fid=214) ORDER BY id DESC, `created` DESC LIMIT 0,16
13 (241.04118347168): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294721086) AND (fid=214) ORDER BY id DESC, `created` DESC LIMIT 0,16
14 (!!!!! 13141.15524292): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=214 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294721086 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
15 (!!!!! 9666.919708252): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=214 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294721086 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
16 (!!!!! 2024.8889923096): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294721086 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
17 (!!!!! 6062.0307922363): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294721086 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3
18 (450.13427734375): SELECT name,id,title FROM jos_deeppockets WHERE id=214 LIMIT 1
19 (52.928924560547): SELECT name,id,title FROM jos_deeppockets WHERE id=214 LIMIT 1
20 (462.05520629883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
21 (468.96934509277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
22 (195.98007202148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
23 (108.00361633301): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
24 (!!!!! 3034.8300933838): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
25 (!!!!! 7948.8754272461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
26 (123.97766113281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
27 (89.883804321289): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
28 (96.08268737793): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
29 (89.883804321289): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
30 (!!!!! 2628.8032531738): SELECT conference_items.channel_id, conference_items.tracking_code FROM conference_items LEFT JOIN conference_groups ON conference_groups.id = conference_items.group_id LEFT JOIN jos_deeppockets ON jos_deeppockets.id = conference_items.channel_id LEFT JOIN jos_journal ON jos_journal.cat = jos_deeppockets.cat AND jos_journal.real = 1 AND jos_journal.directory IS NOT NULL WHERE 1 = 1 ORDER BY conference_items.id
31 (!!!!! 4687.0708465576): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294721086 LIMIT 1
32 (309.94415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294721086 LIMIT 1
33 (567.91305541992): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294721086 LIMIT 1
34 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294721086 LIMIT 1
35 (218.15299987793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294721086 LIMIT 1
36 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294721086 LIMIT 1
37 (82.969665527344): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294721086 LIMIT 1
38 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294721086 LIMIT 1
39 (!!!!! 1295.0897216797): SELECT id, title, module, position, content, showtitle, params FROM jos_modules AS m INNER JOIN jos_modules_menu AS mm ON mm.moduleid = m.id WHERE m.published = 1 AND m.access <= 0 AND m.client_id != 1 AND ( mm.menuid = 0 OR mm.menuid = 294721086 ) ORDER BY ordering
40 (!!!!! 5416.8701171875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
41 (127.79235839844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
42 (151.8726348877): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 98 AND `site_id` = 10 AND `published` = 1
43 (61.03515625): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 99 AND `site_id` = 10 AND `published` = 1
44 (!!!!! 2934.9327087402): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
45 (169.99244689941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
46 (!!!!! 4291.0575866699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
47 (175.95291137695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
48 (!!!!! 3527.1644592285): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
49 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
50 (!!!!! 1859.9033355713): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
51 (135.18333435059): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
52 (551.93901062012): SELECT name FROM jos_deeppockets WHERE id=294721086 LIMIT 1
53 (345.94535827637): SELECT name FROM jos_deeppockets_archive WHERE id=294721086 LIMIT 1
54 (69.141387939453): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'
55 (111.10305786133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
56 (622.98774719238): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
57 (!!!!! 13081.073760986): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
58 (!!!!! 1002.0732879639): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
59 (!!!!! 3603.9352416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
60 (!!!!! 4571.9146728516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
61 (!!!!! 3342.866897583): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1
62 (!!!!! 2476.9306182861): SELECT fid FROM jos_deeppockets WHERE id=294721086 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294721086 AND published='1' LIMIT 1
63 (866.88995361328): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`
64 (!!!!! 1584.0530395508): select jos_twitters.link from jos_twitters where cat=10
65 (57.93571472168): select jos_facebook.link from jos_facebook where cat=10
66 (59.127807617188): select jos_google_plus.link from jos_google_plus where cat=10
67 (303.98368835449): select jos_linkedin.link from jos_linkedin where cat=10
68 (650.16746520996): SELECT fid FROM jos_deeppockets WHERE id=294721086 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294721086 AND published='1' LIMIT 1
69 (307.08312988281): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`
70 (!!!!! 2962.8276824951): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
71 (587.94021606445): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
72 (389.09912109375): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
73 (!!!!! 7463.9320373535): SELECT show_live FROM jos_com_show_setting LIMIT 1
74 (79.870223999023): SELECT show_live FROM jos_com_show_setting LIMIT 1
75 (681.16188049316): SELECT show_live FROM jos_com_show_setting LIMIT 1
76 (164.03198242188): SELECT show_live FROM jos_com_show_setting LIMIT 1
77 (190.97328186035): SELECT show_live FROM jos_com_show_setting LIMIT 1
78 (389.09912109375): SELECT show_live FROM jos_com_show_setting LIMIT 1
79 (!!!!! 1792.1924591064): SELECT show_live FROM jos_com_show_setting LIMIT 1
80 (346.89903259277): SELECT show_live FROM jos_com_show_setting LIMIT 1
81 (!!!!! 1250.9822845459): SELECT show_live FROM jos_com_show_setting LIMIT 1
82 (70.095062255859): SELECT show_live FROM jos_com_show_setting LIMIT 1
83 (!!!!! 1369.9531555176): SELECT show_live FROM jos_com_show_setting LIMIT 1
84 (272.98927307129): SELECT show_live FROM jos_com_show_setting LIMIT 1
85 (657.08160400391): SELECT show_live FROM jos_com_show_setting LIMIT 1
86 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1
87 (!!!!! 2305.9844970703): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
88 (262.97569274902): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (936.03134155273): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (!!!!! 7128.0002593994): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (555.03845214844): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (562.90626525879): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (602.00691223145): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (!!!!! 1654.8633575439): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (273.9429473877): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (924.11041259766): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (496.14906311035): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (979.18510437012): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (167.1314239502): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (988.96026611328): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 1127.0046234131): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
105 (!!!!! 1309.1564178467): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
106 (940.08445739746): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (93.936920166016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (!!!!! 2269.983291626): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
109 (!!!!! 3479.00390625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
110 (644.92225646973): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (!!!!! 4861.8316650391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (!!!!! 2451.1814117432): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (786.06605529785): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (!!!!! 1698.9707946777): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
115 (237.94174194336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
116 (!!!!! 2626.895904541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
117 (!!!!! 2255.916595459): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
118 (!!!!! 1622.200012207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
119 (688.07601928711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
120 (524.99771118164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
121 (675.20141601562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
122 (!!!!! 1626.0147094727): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 194680.92918396): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (660.18104553223): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721086 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721086 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (96.08268737793): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (48.160552978516): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (53.167343139648): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (516.89147949219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (384.09233093262): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (206.94732666016): SELECT name FROM jos_deeppockets WHERE id=214
138 (45.061111450195): SELECT name FROM jos_deeppockets WHERE id=214
139 (813.00735473633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (!!!!! 1034.0213775635): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (129.93812561035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
142 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
143 (!!!!! 11394.97756958): TRUNCATE TABLE jos_trademed_module
144 (!!!!! 1950.9792327881): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (123.97766113281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (657.08160400391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
149 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
150 (!!!!! 1685.8577728271): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (125.88500976562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
152 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
153 (!!!!! 1021.8620300293): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721086 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721086 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (774.86038208008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
155 (855.92269897461): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
156 (62.942504882812): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (!!!!! 3540.0390625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
158 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721086 AND published='1' LIMIT 1
159 (564.0983581543): select jos_twitters.link from jos_twitters where cat=10
160 (57.93571472168): select jos_facebook.link from jos_facebook where cat=10
161 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10
162 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10