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Ultrasound Aspiration Needle Guides Lung Cancer Treatment

By MedImaging International staff writers
Posted on 04 Nov 2021

A new endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) needle effectively gathers tissue samples critical for non-small cell lung cancer (NSCLC) treatment.

The Olympus (Tokyo, Japan) ViziShot 2 FLEX 19G EBUS-TBNA needle features a needle tip design with spiral laser cuts along the sides of the needle surface provide greater flexibility and angulation capabilities to sample targets in difficult-to-reach locations. For pinpoint accuracy, the distal end is treated with spiral echogenic markings to optimize visualization of the needle tip on the ultrasound image. The enhanced visibility facilitates correct capsule-to-capsule technique to optimize sample collection.

A proprietary double-locking safety feature helps avoid accidental patient and personnel injury, as well as damage to the EBUS scope. The large inner lumen enables substantial tissue collection, with a 72% increase in inner surface over the 21-G needle and 144% increase over the 22-G, increasing success rates for collection of important markers such as epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS-1). In immunotherapy treatment, it can also target inhibition of the cell death receptor (PD-1) or its ligand (PD-L1).

Results of a recent study showed that 58% of the specimens collected with the 19-G needle EBUS-TBNA contained more than 500 malignant cells, and 22% had 200-500 malignant cells. The success rates for marker testing stood at 90% for PD-L1 and EGFR, and 86% for ALK. There were no adverse effects on tissue analysis due to blood contamination, and no additional traumas were seen, when compared to smaller gauge needles. The study was published in the July 2021 edition of Journal of Bronchology and Interventional Pulmonology.

“We are very pleased to see the results showing the 19-G has a high success rate in testing for molecular markers and immune checkpoint inhibitor targets,” said Lynn Ray, vice president and general manager of the Global Respiratory Business Unit at Olympus. “Samples with a high number of tumor cells give the pathology team more to work with, which helps the oncology team make a timely diagnosis and gives them the information needed to provide personalized, targeted, lung cancer treatment.”

EBUS-TBNA is a procedure used in the diagnosis and staging of lung cancer, allowing physicians to visualize diseased tissue, lymph nodes, or lesions beyond the walls of the airways. Samples from parts of the lymph node that require further investigation can be taken using a specialized needle. The procedure has proved a less invasive and cost-effective method to diagnose and stage lung cancer.

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63 (!!!!! 1013.9942169189): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

64 (!!!!! 1832.9620361328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

65 (!!!!! 1494.8844909668): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

66 (248.90899658203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

67 (!!!!! 6078.9585113525): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

68 (538.82598876953): SELECT fid FROM jos_deeppockets WHERE id=294790404 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294790404 AND published='1' LIMIT 1

69 (!!!!! 6819.0097808838): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

70 (!!!!! 1017.8089141846): select jos_twitters.link from jos_twitters where cat=10

71 (247.95532226562): select jos_facebook.link from jos_facebook where cat=10

72 (!!!!! 6319.9996948242): select jos_google_plus.link from jos_google_plus where cat=10

73 (181.91337585449): select jos_linkedin.link from jos_linkedin where cat=10

74 (!!!!! 1640.0814056396): SELECT fid FROM jos_deeppockets WHERE id=294790404 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294790404 AND published='1' LIMIT 1

75 (118.97087097168): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=214 ORDER BY `ordering`

76 (349.04479980469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790404 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

77 (!!!!! 1075.0293731689): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790404 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

78 (266.07513427734): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

79 (370.97930908203): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (168.80035400391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (141.14379882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (126.83868408203): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (95.129013061523): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (135.89859008789): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (114.91775512695): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (361.91940307617): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790404 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

94 (78.201293945312): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790404 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

95 (78.916549682617): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

96 (316.14303588867): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (106.8115234375): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (76.055526733398): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (59.843063354492): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

110 (496.14906311035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

111 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

112 (83.92333984375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790404 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790404 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (!!!!! 1730.9188842773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

115 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

116 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294790404 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (438.21334838867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294790404 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

118 (577.92663574219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (354.05158996582): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

120 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

121 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

122 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

123 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

124 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

125 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

126 (47.206878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

127 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

128 (406.98051452637): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790404 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790404 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 1340770.0061798): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (237.94174194336): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (173.09188842773): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (101.08947753906): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (72.956085205078): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (108.00361633301): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (401.97372436523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (347.13745117188): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (136.13700866699): SELECT name FROM jos_deeppockets WHERE id=214

140 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=214

141 (432.96813964844): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (374.07875061035): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

144 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

145 (313.04359436035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

148 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

149 (!!!!! 1027.1072387695): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

150 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

151 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

152 (258.9225769043): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790404 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790404 AND type='deeppockets_item' AND published='1' LIMIT 1

153 (84.161758422852): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

154 (96.08268737793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)

155 (105.85784912109): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

156 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

157 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790404 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790404 AND published='1' LIMIT 1

158 (69.856643676758): select jos_twitters.link from jos_twitters where cat=10

159 (48.160552978516): select jos_facebook.link from jos_facebook where cat=10

160 (25.98762512207): select jos_google_plus.link from jos_google_plus where cat=10

161 (46.014785766602): select jos_linkedin.link from jos_linkedin where cat=10

162 (291.10908508301): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

163 (!!!!! 3246.0689544678): insert into jos_banners_delta values (14615,'2025-04-30 08:24:56','3.133.142.101','view'),(14202,'2025-04-30 08:24:56','3.133.142.101','view'),(14203,'2025-04-30 08:24:56','3.133.142.101','view')

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