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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Portable PET Scanner to Detect Earliest Stages of Alzheimer’s Disease

By MedImaging International staff writers
Posted on 05 Nov 2024

Image: The portable, upright PET scanner will allow a patient to sit in a chair that travels with the unit (Photo courtesy of Goldan Lab)

During a positron emission tomography (PET) scan, a radioactive tracer is injected into the bloodstream, where it accumulates in the targeted tissue and emits signals that the PET scanner detects. These signals are then converted into images. However, current PET scanners often suffer from low spatial resolution, which limits image quality and hinders the reliable quantification of biomarkers such as amyloid plaques and tau tangles—protein aggregates associated with Alzheimer’s disease. Researchers are now developing a portable, high-resolution PET scanner capable of detecting the early stages of Alzheimer’s disease.

This new PET scanner, being created by researchers at Weill Cornell Medicine (New York, NY, USA), features an upright design that allows patients to sit in a chair that moves with the unit, enhancing portability and accessibility. This innovation enables the scanner to be transported to medical centers lacking advanced brain imaging technologies, thereby extending high-quality care to a more diverse patient population. In a proof-of-concept study, the team developed the Prism-PET scanner, which boasts the highest resolution of any PET scanner to date. This device can identify "hot spots," or areas with elevated concentrations of the radioactive tracer, that are less than 1 mm in diameter when tested with brain phantoms, which mimic human tissue. In contrast, commercially available PET scanners produce images with considerably less detail.

The researchers plan to utilize Prism-PET to identify tau tangles in the transentorhinal cortex, a critical hub for memory, navigation, and temporal perception. This area is the first to show the presence of tau tangles, signaling the onset of Alzheimer’s disease even before the appearance of symptoms like mild cognitive impairment. To enhance imaging capabilities further, the scientists will refine motion compensation techniques to minimize blurring in PET images caused by patient movement. Following the FDA's 2023 approval of lecanemab, a monoclonal antibody that targets amyloid plaques and is currently the only treatment demonstrated to slow Alzheimer’s progression, the demand for PET imaging has surged. The scanner's compact design means that even community hospitals and other healthcare facilities do not require a dedicated space for brain PET imaging. Additionally, one possibility for meeting this demand includes using the scanner in a mobile unit, such as a truck, that can travel to underserved areas.

“Our overall goal is two-fold—having the highest performance brain PET scanner available, while also addressing its accessibility and portability to serve the community,” said Dr. Amir H. Goldan, associate professor of electrical engineering in radiology at Weill Cornell Medicine. “The earlier you can diagnose Alzheimer's disease, the better the chances of therapy being effective.”

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84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

91 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

92 (852.10800170898): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802981 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (!!!!! 3179.0733337402): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

94 (86.784362792969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

95 (317.09671020508): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802981 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (!!!!! 5943.0599212646): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (527.85873413086): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

99 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

100 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

101 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

102 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

103 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

104 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

105 (55.789947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

106 (209.80834960938): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 50199.98550415): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (!!!!! 8549.9286651611): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802981 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802981 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 18958.806991577): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (127.07710266113): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (319.00405883789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (316.14303588867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (474.92980957031): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (180.95970153809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (656.1279296875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (256.06155395508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (190.01960754395): SELECT name FROM jos_deeppockets WHERE id=213

121 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=213

122 (616.07360839844): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (!!!!! 1850.1281738281): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

125 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

126 (!!!!! 4801.9886016846): TRUNCATE TABLE jos_trademed_module

127 (!!!!! 1901.8650054932): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802981 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (!!!!! 3257.0362091064): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (!!!!! 1184.9403381348): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

131 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

132 (!!!!! 1104.1164398193): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

134 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

135 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802981 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802981 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

137 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

138 (51.021575927734): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

140 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802981 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802981 AND published='1' LIMIT 1

141 (43.153762817383): select jos_twitters.link from jos_twitters where cat=10

142 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

143 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

144 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

145 (344.99168395996): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 1087.9039764404): insert into jos_banners_delta values (14615,'2025-06-21 01:12:27','216.73.216.120','view'),(14202,'2025-06-21 01:12:27','216.73.216.120','view'),(14203,'2025-06-21 01:12:27','216.73.216.120','view')

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