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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

New Scans Light Up Aggressive Tumors for Better Treatment

By MedImaging International staff writers
Posted on 18 Dec 2024

Image: The chemical compound lights up treatment-resistant cancers on imaging scans (Photo courtesy of King’s College London)

Non-small cell lung cancer is the most prevalent type of lung cancer. Although standard treatments such as surgery, radiotherapy, chemotherapy, and immunotherapy have advanced, survival rates have remained relatively unchanged in the last decade. Typically, patients with lung cancer begin treatment, such as chemotherapy, and then wait 12 weeks for a CT or PET scan to assess whether the tumor has shrunk, remained stable, or grown. However, this 12-week delay can often be too late to adjust the treatment plan, and end-of-life care is frequently the only remaining option. At present, there is no rapid, early method to determine if malignant tumors are resistant to treatment. Now, in a breakthrough, researchers have used a chemical compound to highlight treatment-resistant cancers in imaging scans, helping doctors target and treat the cancer more effectively. This radiotracer – an injected compound used in PET scans – could alert doctors to whether a patient's aggressive cancer will resist chemotherapy before the treatment starts. This approach would prevent unnecessary treatments and allow for alternative therapies to be considered, improving the chances of successful treatment.

Researchers from King’s College London (London, UK repurposed a radiotracer that is already used as a diagnostic tool in clinical trials in the USA and South Korea to reveal treatment-resistant tumors on PET scans. The molecule specifically targets xCT, a protein associated with tumors that are resistant to therapy. The study, published in Nature Communications, demonstrated that therapy-resistant non-small cell lung cancer tumors appeared to "light up like a Christmas tree" on PET scans after the radiotracer was injected. In the study images, PET scans of animal models showed that therapy-resistant cancer cells illuminated more brightly than tumors that responded to treatment.

Additionally, the research revealed that xCT could also be targeted with an antibody-drug conjugate, a new class of drug that targets therapy-resistant cancer cells and selectively destroys them while minimizing toxicity to healthy cells. While this research is still in its early stages, the researchers are hopeful that it could provide new treatment options for patients with aggressive and hard-to-treat cancers, such as lung, pancreatic, and breast cancers. The researchers are preparing to test this approach in humans, with a phase I clinical trial scheduled to begin in January. This trial will recruit 35 patients and use a total-body PET scanner to track xCT expression before and after treatment.

“Our study is the cumulation of five years of work. Frequently, cancer patients find out too late that the treatment they’re on does not work,” said Tim Witney, a Professor of Molecular Imaging from King’s College London, and lead researcher of the study. “The radiotracer 18F-FSPG binds to the tumor-resistant cells and lights up like a Christmas tree in imaging – clearly showing the aggressive cancer. With this technique, we can give the right treatment to the right patient, making it more cost-efficient for the NHS and providing hope for patients with aggressive tumors.”

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83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

91 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

92 (53.882598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803458 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

94 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

95 (322.81875610352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803458 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (528.09715270996): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (303.03001403809): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

99 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

100 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

101 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

102 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

103 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

104 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

105 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

106 (276.08871459961): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 19499.063491821): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (488.0428314209): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803458 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803458 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 6978.0349731445): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (77.009201049805): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (207.90100097656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (167.8466796875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (26.941299438477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (118.97087097168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (262.97569274902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (125.88500976562): SELECT name FROM jos_deeppockets WHERE id=213

121 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=213

122 (566.95938110352): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (448.94218444824): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

125 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

126 (!!!!! 7163.0477905273): TRUNCATE TABLE jos_trademed_module

127 (87.976455688477): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803458 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (876.90353393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

131 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

132 (!!!!! 1114.1300201416): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

134 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

135 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803458 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803458 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (27.894973754883): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

137 (25.98762512207): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

138 (29.087066650391): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

140 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803458 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803458 AND published='1' LIMIT 1

141 (144.00482177734): select jos_twitters.link from jos_twitters where cat=10

142 (28.133392333984): select jos_facebook.link from jos_facebook where cat=10

143 (27.179718017578): select jos_google_plus.link from jos_google_plus where cat=10

144 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

145 (293.01643371582): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (927.92510986328): insert into jos_banners_delta values (14615,'2025-06-21 01:15:57','216.73.216.120','view'),(14202,'2025-06-21 01:15:57','216.73.216.120','view'),(14203,'2025-06-21 01:15:57','216.73.216.120','view')

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