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New Molecular Imaging Test to Improve Lung Cancer Diagnosis

By MedImaging International staff writers
Posted on 10 Mar 2025

Lung cancer continues to be one of the leading causes of cancer-related deaths, primarily because it often goes undetected until it reaches more advanced and aggressive stages. More...

Panitumumab, a humanized antibody used in cancer treatment, targets the epidermal growth factor receptor (EGFR), which is present on the surface of many cancer cells. This receptor is especially abundant in non-small-cell lung cancer, making it a prime target for anti-cancer therapies. Copper-64, a radioactive isotope, is used in positron emission tomography (PET) scans. Now, by combining panitumumab with copper-64, researchers and clinicians can more accurately locate and track tumors and better monitor the effectiveness of treatments.

A team of researchers from the University of Alberta (Edmonton, Canada) has developed a new molecular imaging technique that could improve the detection of lung cancer and offer enhanced monitoring of treatment progress. By pairing panitumumab with copper-64, this new method combines the antibody's precision targeting capability with the exceptional sensitivity of radioisotope detection, providing a tool for earlier and more accurate detection of lung cancer, as well as monitoring treatment responses. Copper-64, when linked to panitumumab, enables clinicians and researchers to track the "metabolic fate" of the antibody, including its accumulation and retention in cancer cells. To evaluate this imaging agent, the team used several preclinical lung cancer models in mice, including a metastasis model to identify lung cancer lesions in distant organs such as the liver. The study, published in Molecular Pharmaceutics, revealed that this imaging technique not only highlights tumors in the lungs but also identifies metastatic tumors in the liver.

This dual capability of detecting both primary and metastatic tumors while providing crucial molecular data about the cancer cells overcomes significant limitations of traditional diagnostic imaging techniques. For example, CT scans often miss smaller tumors or those located in challenging areas like soft tissues, and they do not offer molecular insights into cancer cells. The new PET imaging test can also serve as a valuable tool for tracking cancer growth and metastasis over time. The research team plans to explore further the combination of panitumumab with copper-67, a complementary isotope that can deliver targeted radiation to kill cancer cells. When paired together, panitumumab and copper-67 could locate and destroy cancerous cells while sparing surrounding healthy tissues. The researchers also suggest that other antibody therapies could be combined with radioisotopes, such as copper-64 and copper-67, to improve the detection and treatment of cancer, ultimately advancing patient care and outcomes.

“Instead of exposing the patient to an invasive biopsy, they can go and get an injection, and then we can use a PET scan to help see the tumor and help physicians to determine the best course of therapy,” said study co-author Afsaneh Lavasanifar.

“With our tools, imaging biomarkers like radiolabeled panitumumab and non-invasive PET imaging technology, we can provide valuable information to clinicians about the molecular footprint of cancer cells,” added Frank Wuest, oncology professor in the Faculty of Medicine & Dentistry.

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77 (35.04753112793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

78 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

93 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

94 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804287 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

95 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

96 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

97 (366.2109375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804287 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

98 (359.05838012695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294804258 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

99 (610.8283996582): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

100 (418.90144348145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

101 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

102 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

103 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

104 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

105 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

106 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

107 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

108 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

109 (261.78359985352): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

110 (!!!!! 19786.11946106): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

111 (535.96496582031): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804287 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804287 AND type='deeppockets_item' AND published='1' LIMIT 1

112 (!!!!! 7610.0826263428): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

113 (87.976455688477): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

114 (321.86508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

115 (72.002410888672): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

116 (262.97569274902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

117 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

118 (29.802322387695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

119 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

120 (199.0795135498): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

121 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

122 (311.85150146484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

123 (164.03198242188): SELECT name FROM jos_deeppockets WHERE id=213

124 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=213

125 (572.91984558105): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

126 (596.04644775391): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

127 (140.90538024902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

128 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

129 (!!!!! 11593.103408813): TRUNCATE TABLE jos_trademed_module

130 (117.06352233887): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294804287 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

131 (593.90068054199): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

132 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

133 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

134 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

135 (!!!!! 1754.9991607666): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

136 (85.830688476562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

137 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

138 (62.942504882812): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294804287 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294804287 AND type='deeppockets_item' AND published='1' LIMIT 1

139 (51.975250244141): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

140 (46.968460083008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

141 (70.810317993164): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

142 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

143 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294804287 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294804287 AND published='1' LIMIT 1

144 (121.8318939209): select jos_twitters.link from jos_twitters where cat=10

145 (47.922134399414): select jos_facebook.link from jos_facebook where cat=10

146 (46.014785766602): select jos_google_plus.link from jos_google_plus where cat=10

147 (42.915344238281): select jos_linkedin.link from jos_linkedin where cat=10

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