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PET Software Enhances Diagnosis and Monitoring of Alzheimer's Disease

By MedImaging International staff writers
Posted on 31 Oct 2024

Image: syngo.PET Cortical Analysis software enables the measurement of beta-amyloid and tau protein deposits in the brain (Photo courtesy of Siemens Healthineers)

Alzheimer’s disease is marked by the buildup of beta-amyloid plaques and tau protein tangles in the brain. These deposits of beta-amyloid and tau appear in various brain regions at differing rates as the brain ages. Collectively, these pathological changes result in neurodegeneration, leading to cognitive and clinical deterioration in individuals affected by Alzheimer’s disease. The need for standardized measurements of beta-amyloid plaques via positron emission tomography (PET) has surged following the FDA's approval of new therapeutic drugs targeting Alzheimer's disease. These treatments aim to slow cognitive and functional decline in adults with mild cognitive impairment or mild dementia by eliminating beta-amyloid from the brain. Now, a software application with new features utilizes PET to measure these protein accumulations associated with Alzheimer's disease. Accurately quantifying the accumulation of amyloid plaques and tau proteins in the brains of Alzheimer’s patients can offer clinicians critical diagnostic and staging information pertaining to the disease.

Siemens Healthineers (Forchheim, Germany) has received CE Mark approval for two new features in its syngo.PET Cortical Analysis software. The first feature, Centiloid scoring, standardizes the measurement of brain amyloid plaques in PET scans across three commercially available beta-amyloid PET radiopharmaceuticals used in the diagnosis of Alzheimer’s disease. The second feature, tau PET quantification, evaluates and quantifies the distribution and density of tau protein tangles in the brain using images obtained with the radiopharmaceutical flortaucipir. The implementation of Centiloid scoring for beta-amyloid PET is significant for diagnosis, patient management, and the design of clinical trials focused on Alzheimer’s disease-modifying therapies. Siemens' new Centiloid scoring feature employs a 100-point scale to standardize beta-amyloid PET measurements, allowing clinicians to compare results across various PET scanners and tracers.

Moreover, tau deposits have been found to correlate closely with cognitive performance in individuals with Alzheimer’s disease. The new tau PET quantification feature from Siemens incorporates Braak staging, a six-stage model that classifies the progression of tau pathology in the brain and closely aligns with cognitive impairment levels, with advanced stages linked to more severe cognitive and clinical symptoms. Tau PET has played a vital role in recent amyloid-directed drug trials concerning patient stratification, drug management, and treatment response assessment. Given tau’s strong connection to disease severity, numerous investigational tau-targeted therapies are currently in different stages of clinical development, and tau PET quantification is expected to play a significant role in these trials.

“The addition of Centiloid scoring and tau PET quantification features to our syngo.PET Cortical Analysis software fortifies our integrated and comprehensive portfolio for detection, diagnosis, monitoring, and follow-up related to Alzheimer’s disease,” said Martin Cordell, PhD, director of product lifecycle management at Siemens Healthineers Molecular Imaging.

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78 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (!!!!! 3298.0442047119): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (109.91096496582): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (147.10426330566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

91 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

92 (683.06922912598): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802947 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (!!!!! 7748.1269836426): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

94 (162.12463378906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

95 (778.1982421875): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802947 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (713.10997009277): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (437.97492980957): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

99 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

100 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

101 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

102 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

103 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

104 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

105 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

106 (803.94744873047): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802947 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802947 AND type='deeppockets_item' AND published='1' LIMIT 1

107 (!!!!! 22480.010986328): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

108 (100.85105895996): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

109 (576.01928710938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

110 (58.174133300781): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

111 (375.98609924316): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

112 (53.882598876953): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

113 (319.9577331543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

114 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

115 (373.12507629395): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

116 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

117 (333.07075500488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

118 (!!!!! 4462.0037078857): SELECT name FROM jos_deeppockets WHERE id=213

119 (101.08947753906): SELECT name FROM jos_deeppockets WHERE id=213

120 (751.97219848633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

121 (536.91864013672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

122 (!!!!! 2438.0683898926): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

123 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

124 (519.0372467041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

125 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

126 (!!!!! 2557.0392608643): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

127 (124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

128 (!!!!! 3086.8053436279): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

129 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

130 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

131 (64.849853515625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802947 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802947 AND type='deeppockets_item' AND published='1' LIMIT 1

132 (45.061111450195): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

133 (139.95170593262): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

134 (320.9114074707): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

135 (!!!!! 6229.8774719238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

136 (!!!!! 3956.0794830322): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802947 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802947 AND published='1' LIMIT 1

137 (123.02398681641): select jos_twitters.link from jos_twitters where cat=10

138 (33.140182495117): select jos_facebook.link from jos_facebook where cat=10

139 (32.901763916016): select jos_google_plus.link from jos_google_plus where cat=10

140 (!!!!! 2435.9226226807): select jos_linkedin.link from jos_linkedin where cat=10

141 (445.12748718262): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

142 (!!!!! 1701.1165618896): insert into jos_banners_delta values (14615,'2025-08-01 22:27:04','216.73.216.210','view'),(14202,'2025-08-01 22:27:04','216.73.216.210','view'),(14203,'2025-08-01 22:27:04','216.73.216.210','view')

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