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PSMA-PET Imaging Improves Outcomes for Patients with Recurrent Prostate Cancer

By MedImaging International staff writers
Posted on 28 Oct 2024

Image: A study has shown long-term benefits of PSMA-PET in patients with recurrent prostate cancer (Photo courtesy of 123RF)

While prostate-specific membrane antigen positron emission tomography (PSMA-PET) has demonstrated enhanced sensitivity and specificity compared to traditional imaging techniques for detecting biochemical recurrent (BCR) prostate cancer, the long-term effects of a widespread shift to this imaging method remain uncertain. Now, a new study indicates that even with modest improvements in early detection, PSMA-PET imaging may enhance both the length and quality of life for patients dealing with recurrent prostate cancer.

In the study, researchers at the University of York’s Centre for Health Economics (York, UK) set out to evaluate the long-term outcomes of PSMA-PET imaging in comparison to conventional imaging strategies in patients with recurrent prostate cancer. This decision analytic modeling study simulated patient outcomes following initial definitive local therapy for BCR. The study utilized data from existing literature and a retrospective cohort study performed at two institutions. The primary analysis presumed modest advantages of earlier detection and treatment, while scenario analyses explored variables such as prostate-specific antigen (PSA) levels at the time of imaging and the differing outcomes of early versus delayed treatment. The main outcomes measured included the detection of metastases, prostate cancer-related deaths, and the gain in life-years and quality-adjusted life-years (QALYs).

The results from this decision analytic modeling study projected that employing PSMA-PET upfront for imaging in BCR prostate cancer would likely result in increased life-years and QALYs, along with a reduction in prostate cancer-related deaths. The clinical benefits were anticipated to be consistent across varying PSA levels. Furthermore, the advantages linked to early detection and the initiation of salvage therapies were sensitive to assumptions about the effectiveness of early treatment. Thus, the findings imply that with modest benefits from early detection, PSMA-PET imaging could potentially enhance both the duration and quality of life for patients with recurrent prostate cancer.

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88 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (!!!!! 1543.9987182617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

94 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

95 (110.86463928223): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802891 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (!!!!! 1940.9656524658): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

97 (126.12342834473): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

98 (740.05126953125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802891 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

99 (!!!!! 1296.9970703125): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

100 (596.04644775391): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

101 (718.83201599121): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

102 (308.03680419922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

103 (702.1427154541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

104 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

105 (!!!!! 2861.0229492188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

106 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

107 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

108 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

109 (794.88754272461): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

110 (!!!!! 56056.976318359): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

111 (!!!!! 1292.9439544678): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802891 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802891 AND type='deeppockets_item' AND published='1' LIMIT 1

112 (853.06167602539): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

113 (71.048736572266): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

114 (988.96026611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

115 (!!!!! 1497.9839324951): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

116 (!!!!! 1065.9694671631): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

117 (59.127807617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

118 (!!!!! 1125.8125305176): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

119 (375.98609924316): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

120 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

121 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

122 (!!!!! 1695.1560974121): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

123 (739.09759521484): SELECT name FROM jos_deeppockets WHERE id=213

124 (195.98007202148): SELECT name FROM jos_deeppockets WHERE id=213

125 (849.96223449707): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

126 (668.04885864258): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

127 (!!!!! 6597.9957580566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

128 (!!!!! 12118.101119995): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

129 (!!!!! 11613.845825195): TRUNCATE TABLE jos_trademed_module

130 (257.96890258789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802891 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

131 (756.02531433105): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

132 (710.96420288086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

133 (!!!!! 2751.1119842529): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

134 (416.04042053223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

135 (!!!!! 1950.9792327881): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

136 (667.09518432617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

137 (676.15509033203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

138 (286.81755065918): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802891 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802891 AND type='deeppockets_item' AND published='1' LIMIT 1

139 (607.96737670898): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

140 (267.98248291016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

141 (654.93583679199): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

142 (543.83277893066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

143 (670.9098815918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802891 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802891 AND published='1' LIMIT 1

144 (487.08915710449): select jos_twitters.link from jos_twitters where cat=10

145 (158.07151794434): select jos_facebook.link from jos_facebook where cat=10

146 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

147 (97.036361694336): select jos_linkedin.link from jos_linkedin where cat=10

148 (!!!!! 1021.146774292): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

149 (!!!!! 1120.0904846191): insert into jos_banners_delta values (14615,'2025-08-01 22:23:43','216.73.216.210','view'),(14202,'2025-08-01 22:23:43','216.73.216.210','view'),(14203,'2025-08-01 22:23:43','216.73.216.210','view')

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