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New Radiotracer Could Be a Game Changer for Detection of Coronary Artery Disease

By MedImaging International staff writers
Posted on 11 Oct 2024

Image: Healthcare professionals reviewing myocardial perfusion PET images (Photo courtesy of GE HealthCare)

Coronary artery disease (CAD) is the most prevalent form of heart disease and remains the leading cause of death for both men and women in the U.S., accounting for 695,000 deaths in 2021. Approximately six million myocardial perfusion imaging (MPI) procedures are performed annually in the U.S. to assess blood flow through the heart muscle and to evaluate the presence, extent, and severity of myocardial ischemia or infarction. Currently, single-photon emission computed tomography (SPECT) MPI is the primary nuclear cardiology procedure used to detect CAD. While positron emission tomography (PET) MPI offers higher diagnostic accuracy compared to SPECT MPI, the use of PET for MPI is limited due to restricted access to the necessary PET tracers. However, this is poised to change with the introduction of a new radiotracer that could revolutionize CAD diagnosis, the disease responsible for the highest mortality worldwide.

GE HealthCare's (Chicago, IL, USA) Flyrcado (flurpiridaz F 18) injection is the first PET MPI agent specifically designed for the detection of CAD. Intended for patients with known or suspected CAD, Flyrcado provides greater diagnostic efficacy than SPECT MPI. The injection can be produced offsite in a pharmacy and delivered as a ready-to-use dose, potentially broadening access to PET MPI, improving diagnostic accuracy in hard-to-image patients, such as those with a high body mass index (BMI) and women. With a 109-minute half-life, significantly longer than current PET MPI tracers, Flyrcado eliminates the need for on-site tracer production and generator maintenance, allowing for wider distribution to hospitals and imaging centers. The extended half-life also makes it the first viable option for combining exercise stress testing with cardiac PET imaging for CAD, enabling the most comprehensive protocol for assessing ischemia in patients. Additionally, Flyrcado offers the ability to rescan patients during the same imaging session in the event of technical issues, rather than requiring a separate appointment.

The U.S. Food and Drug Administration (FDA) has approved Flyrcado for detecting CAD. This agent joins two other F 18 imaging agents in GE HealthCare's FDA-approved PET molecular imaging portfolio: Cerianna (fluoroestradiol F 18) injection, used for detecting estrogen receptor-positive lesions as an adjunct to biopsy in patients with metastatic or recurrent breast cancer, and Vizamyl (flutemetamol F 18) injection, a PET tracer used for imaging beta-amyloid neuritic plaque density in adults being evaluated for Alzheimer’s disease or other cognitive disorders. Flyrcado is expected to be available in initial U.S. markets in early 2025, with expanded availability to follow.

“As the first and only FDA-approved F 18 PET MPI radiotracer for CAD detection, Flyrcado can make a real difference to clinicians and their patients,” said Kevin O’Neill, CEO of the Pharmaceutical Diagnostics (PDx) segment of GE HealthCare. “This is another example of GE HealthCare’s commitment to innovating and investing to shape the future of molecular imaging, increasing diagnostic confidence and addressing unmet patient needs.”

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81 (174.04556274414): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (212.9077911377): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (188.82751464844): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (694.03648376465): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (!!!!! 6003.8566589355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

91 (571.01249694824): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

92 (!!!!! 6937.0269775391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802723 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (!!!!! 2726.7932891846): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

94 (315.90461730957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

95 (!!!!! 1332.9982757568): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802723 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (!!!!! 7770.0614929199): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (879.04930114746): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (502.10952758789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

99 (818.96781921387): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

100 (293.01643371582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

101 (!!!!! 1069.0689086914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

102 (925.06408691406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

103 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

104 (!!!!! 3093.957901001): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

105 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

106 (537.15705871582): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 94441.890716553): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (!!!!! 15047.073364258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802723 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802723 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (!!!!! 5370.1400756836): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (!!!!! 35418.98727417): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (!!!!! 6301.8798828125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (83.92333984375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (822.78251647949): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (417.94776916504): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (53.167343139648): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (638.00811767578): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (158.07151794434): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (!!!!! 2712.0113372803): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (!!!!! 1215.934753418): SELECT name FROM jos_deeppockets WHERE id=213

121 (283.95652770996): SELECT name FROM jos_deeppockets WHERE id=213

122 (!!!!! 2361.0591888428): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (!!!!! 1152.0385742188): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (!!!!! 6476.879119873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

125 (!!!!! 1801.9676208496): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

126 (!!!!! 17107.009887695): TRUNCATE TABLE jos_trademed_module

127 (!!!!! 2771.1391448975): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802723 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (!!!!! 1287.9371643066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (283.00285339355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (!!!!! 2364.8738861084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

131 (254.15420532227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

132 (!!!!! 2730.131149292): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (!!!!! 2383.9473724365): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

134 (!!!!! 1122.9515075684): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

135 (!!!!! 2693.8915252686): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802723 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802723 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (56.982040405273): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

137 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

138 (334.9781036377): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (703.09638977051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

140 (272.03559875488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802723 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802723 AND published='1' LIMIT 1

141 (!!!!! 1250.0286102295): select jos_twitters.link from jos_twitters where cat=10

142 (149.96528625488): select jos_facebook.link from jos_facebook where cat=10

143 (!!!!! 1003.9806365967): select jos_google_plus.link from jos_google_plus where cat=10

144 (!!!!! 2456.9034576416): select jos_linkedin.link from jos_linkedin where cat=10

145 (!!!!! 1417.875289917): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

146 (!!!!! 6653.7857055664): insert into jos_banners_delta values (14615,'2025-08-01 22:23:41','216.73.216.210','view'),(14202,'2025-08-01 22:23:41','216.73.216.210','view'),(14203,'2025-08-01 22:23:41','216.73.216.210','view')

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