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New Imaging Method Non-Invasively Detects Inflammatory Bowel Disease

By MedImaging International staff writers
Posted on 29 Jul 2024

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory condition that includes two primary groups: Crohn's disease and ulcerative colitis. More...

Despite progress in managing IBD, there are ongoing challenges in improving diagnostic accuracy, resolving treatment intolerance, and managing the recurrent cycles of remission and relapse. Additionally, long-term IBD increases the risk of cancer, necessitating continual monitoring of disease activity. Currently, no methods can accurately detect and differentiate active inflammation from chronic disease. MRI and CT scans reveal structural changes in the bowel, and other imaging methods identify increases in immune cell numbers in tissues, but none of these techniques fully capture the dynamic immune responses in the colon. Now, a novel imaging technique, granzyme B PET, has been developed to non-invasively detect IBD and provide real-time imagery of active inflammation within tissues. According to research published in the July issue of The Journal of Nuclear Medicine, the insights from PET imaging could help monitor the effectiveness of IBD treatments and potentially lead to more tailored patient management strategies.

In this research, scientists at Massachusetts General Hospital (MGH, Boston, MA, USA) explored the potential of the granzyme B gene as a biomarker for IBD detection and treatment response prediction. Human tissue samples from Crohn’s disease and ulcerative colitis patients, both during active and inactive phases, as well as from non-inflamed bowel tissues, were stained to measure granzyme B expression. The findings showed that granzyme B levels were significantly higher in inflamed tissues compared to non-inflamed ones, with active disease tissues showing higher levels than those from inactive disease. Additionally, tissue samples from IBD patients who responded to treatments exhibited lower granzyme B expression compared to those from non-responders.

Further, the researchers assessed granzyme B expression changes in a murine model, including colitis-induced and control mice. These mice underwent 68Ga-NOTA-GZP PET imaging at one, three, and four weeks. The PET imaging revealed significantly higher bowel uptake of 68Ga-NOTA-GZP in the colitis-induced mice compared to control mice. Post-treatment, although 68Ga-NOTA-GZP uptake decreased in the colitis-induced mice, it remained significantly higher than in the controls throughout the study.

“A non-invasive imaging method to detect immune system activation with high resolution is key to improving IBD management,” said Pedram Heidari, MD, radiologist and service chief of nuclear medicine at Massachusetts General Hospital. “Granzyme B PET can help with the timely detection of the active disease, determination of the need to start treatment, and monitoring the response to treatment to ensure the resolution of the inflammation. This is particularly important for monitoring inflammation in the parts of the bowel that are not accessible for endoscopy and tissue sampling. This is a unique tool that can significantly change the trajectory of disease by closely monitoring treatment efficacy and is the true definition of precision medicine.”

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90 (78.916549682617): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
91 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
105 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
106 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
107 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802007 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (62.942504882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802007 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
109 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
110 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
111 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802007 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (694.99015808105): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294802007 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
113 (707.86476135254): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (465.15464782715): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
115 (179.05235290527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
116 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
117 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
118 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
119 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
120 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
121 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
122 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
123 (391.00646972656): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
124 (!!!!! 29184.818267822): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
125 (658.03527832031): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802007 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802007 AND type='deeppockets_item' AND published='1' LIMIT 1
126 (!!!!! 9765.8634185791): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (184.05914306641): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
128 (74.863433837891): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
130 (99.18212890625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
132 (421.04721069336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (113.01040649414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
134 (59.127807617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
136 (632.04765319824): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (524.99771118164): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
138 (405.07316589355): SELECT name FROM jos_deeppockets WHERE id=213
139 (63.896179199219): SELECT name FROM jos_deeppockets WHERE id=213
140 (772.95303344727): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (741.00494384766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
142 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
143 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
144 (!!!!! 12807.846069336): TRUNCATE TABLE jos_trademed_module
145 (143.05114746094): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802007 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (83.92333984375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294802007 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
147 (590.08598327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
149 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
150 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
151 (!!!!! 1219.9878692627): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
152 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
153 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
154 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294802007 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294802007 AND type='deeppockets_item' AND published='1' LIMIT 1
155 (44.107437133789): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
156 (43.869018554688): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
157 (56.028366088867): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
158 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
159 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294802007 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294802007 AND published='1' LIMIT 1
160 (40.054321289062): select jos_twitters.link from jos_twitters where cat=10
161 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10
162 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10
163 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10
164 (306.12945556641): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
165 (!!!!! 1305.103302002): insert into jos_banners_delta values (14615,'2025-08-02 15:07:57','216.73.216.210','view'),(14202,'2025-08-02 15:07:57','216.73.216.210','view'),(14203,'2025-08-02 15:07:57','216.73.216.210','view')