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New Radiotracer Generates High Quality and Readily Interpretable Images of Cardiac Amyloidosis

By MedImaging International staff writers
Posted on 24 Jun 2024

Cardiac amyloidosis, often referred to as the "Alzheimer’s disease of the heart," is a progressive and incurable condition characterized by abnormal protein accumulation in the body's tissues and organs. More...

Approximately 20% of patients with amyloid deposits in their hearts suffer premature mortality. Although recent advancements in treatment have significantly improved patient outcomes, the median survival rate for those affected is still only about three to five years. Existing therapies are effective in slowing amyloid buildup but do not benefit patients with advanced-stage disease. Early detection of cardiac amyloidosis is therefore essential, yet no imaging agents specifically approved by the Food and Drug Administration (FDA) are currently available for this purpose.

In response to this issue, researchers at the University of Tennessee Graduate School of Medicine (Knoxville, TN, USA) have developed a new radiotracer, a technetium-99m labeled version of the pan-amyloid reactive peptide p5+14 (99mTc-p5+14). This radiotracer produces high-quality, easily interpretable images of cardiac amyloidosis. In an initial human study, five healthy volunteers and 30 patients newly diagnosed with light chain or transthyretin amyloidosis underwent imaging with 99mTc-p5+14 using standard planar gamma scintigraphy and SPECT/CT. Alongside this, blood samples were collected for serum biomarkers analysis, and transthoracic echocardiograms were performed. Most patients also received standard 99mTc-pyrophosphate imaging 72 hours post-99mTc-p5+14 imaging.

The planar and SPECT/CT images generated using 99mTc-p5+14 at one and three hours after injection were of high quality and clearly interpretable. Notably, significant uptake of 99mTc-p5+14 was observed in the hearts of patients with amyloid cardiomyopathy, while no cardiac uptake was detected in healthy volunteers. The 99mTc-p5+14 radiotracer is now being further evaluated in early-stage clinical trials to determine its safety and effectiveness both in patients with cardiac amyloidosis and in healthy subjects. These studies aim to gather data to support a pivotal Phase 3 study and future FDA approval submissions.

“Early and accurate diagnosis of cardiac amyloidosis is crucial to ensure the most positive outcomes for patients,” said Jonathan Wall, PhD, director of the Amyloidosis and Cancer Theranostics Program and professor at the University of Tennessee Graduate School of Medicine. “Imaging with 99mTc-p5+14 could provide an easy to use and interpret technology that could be employed in the community cardiology setting, where SPECT imaging is common, as a rapid screen for amyloid cardiomyopathy in the future.”

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60 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

61 (202.89421081543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

62 (188.11225891113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

63 (132.08389282227): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (515.93780517578): SELECT fid FROM jos_deeppockets WHERE id=294801622 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294801622 AND published='1' LIMIT 1

65 (56.028366088867): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

66 (47.922134399414): select jos_twitters.link from jos_twitters where cat=10

67 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

68 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

69 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

70 (32.901763916016): SELECT fid FROM jos_deeppockets WHERE id=294801622 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294801622 AND published='1' LIMIT 1

71 (32.186508178711): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

72 (243.9022064209): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (190.01960754395): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (34.809112548828): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (76.055526733398): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

107 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

108 (93.936920166016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (79.154968261719): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

111 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

112 (65.803527832031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (547.17063903809): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294801622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (730.03768920898): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (493.04962158203): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (104.18891906738): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

117 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

118 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

119 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

120 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

121 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

122 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

123 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

124 (285.14862060547): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 27036.190032959): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (679.96978759766): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801622 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801622 AND type='deeppockets_item' AND published='1' LIMIT 1

127 (!!!!! 10258.197784424): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' AND dp.id NOT IN (294804816,294804739,294804722,294804707,294804668,294804602) ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' AND dpa.id NOT IN (294804816,294804739,294804722,294804707,294804668,294804602) ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (126.12342834473): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' AND dp.id NOT IN (294804816,294804739,294804722,294804707,294804668,294804602) ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' AND dpa.id NOT IN (294804816,294804739,294804722,294804707,294804668,294804602) ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (114.91775512695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (78.201293945312): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (334.02442932129): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (86.069107055664): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (401.97372436523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (272.98927307129): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (59.127807617188): SELECT name FROM jos_deeppockets WHERE id=213

140 (38.862228393555): SELECT name FROM jos_deeppockets WHERE id=213

141 (878.81088256836): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (684.02290344238): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

144 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

145 (!!!!! 13529.062271118): TRUNCATE TABLE jos_trademed_module

146 (154.97207641602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (68.902969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294801622 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (565.0520324707): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

151 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

152 (!!!!! 1559.9727630615): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

154 (152.1110534668): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

155 (97.990036010742): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294801622 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294801622 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (65.088272094727): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

157 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

158 (60.081481933594): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

160 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294801622 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294801622 AND published='1' LIMIT 1

161 (52.928924560547): select jos_twitters.link from jos_twitters where cat=10

162 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

163 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

164 (78.916549682617): select jos_linkedin.link from jos_linkedin where cat=10

165 (365.9725189209): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 1251.9359588623): insert into jos_banners_delta values (14615,'2025-08-02 15:10:14','216.73.216.210','view'),(14202,'2025-08-02 15:10:14','216.73.216.210','view'),(14203,'2025-08-02 15:10:14','216.73.216.210','view')

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